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  • Title: Design and synthesis of novel conformationally restricted HIV protease inhibitors.
    Author: Salituro FG, Baker CT, Court JJ, Deininger DD, Kim EE, Li B, Novak PM, Rao BG, Pazhanisamy S, Porter MD, Schairer WC, Tung RD.
    Journal: Bioorg Med Chem Lett; 1998 Dec 15; 8(24):3637-42. PubMed ID: 9934485.
    Abstract:
    A set of HIV protease inhibitors represented by compound 2 has previously been described. Structural and conformational analysis of this compound suggested that conformational restriction of the P1/P2 portion of the molecule could lead to a novel set of potent protease inhibitors. Thus, probe compounds 3-7 were designed, synthesized, and found to be potent inhibitors of HIV protease.
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