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  • Title: Vitamin K requirement and the concentration of vitamin K in rat liver.
    Author: Knauer TE, Siegfried CM, Matschiner JT.
    Journal: J Nutr; 1976 Dec; 106(12):1747-51. PubMed ID: 993854.
    Abstract:
    The concentration of vitamin K was determined in the liver of different strains of rats, and in male and female warfarin-resistant rats by feeding 3H-vitamin K in a purified diet. In each case, the level of vitamin K in the liver correlated approximately with the amount of vitamin K fed. The results indicate that differences in the requirement for vitamin K between the sexes and between strains of rats are due principally to different required concentrations of vitamin K in liver and not to differences in absorption or turnover of the vitamin. The results of the determination of vitamin K epoxide levels in male and female warfarin-resistant rats, and other data, suggest that the amount of vitamin K required in liver may be in part due to differences in the activity of the enzyme, vitamin K epoxide reductase.
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