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  • Title: Age-dependence of hepatic dimethylnitrosamine-demethylase activity in the rat.
    Author: Davies DL, Bryant GM, Arcos JC, Argus MF.
    Journal: J Natl Cancer Inst; 1976 May; 56(5):1057-8. PubMed ID: 994198.
    Abstract:
    The mixed-function oxidase which activates the carcinogen dimethylnitrosamine (DMN) was determined in the rat liver as a function of animal age. DMN-demethylase activity increased considerably at first to reach a maximum on day 29, and then substantially decreased to day 59; thereafter, enzyme activity remained essentially stable up to at least day 110. Pretreatment with 3-methylcholanthrene, which caused a pronounced decrease in this enzyme activity, did not affect the general shape of the age-dependence curve. The results suggest that rats between weaning and sexual maturity are more susceptible to the carcinogenic effects of pulse doses of DMN than are neonates or adult animals.
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