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  • Title: Bilateral eyelid edema: an uncommon presentation of Rosai-Dorfman disease.
    Author: Pelletier CR, Jordan DR, Jabi M.
    Journal: Ophthalmic Plast Reconstr Surg; 1999 Jan; 15(1):52-5. PubMed ID: 9949430.
    Abstract:
    PURPOSE: Rosai-Dorfman disease (sinus histiocytosis with massive lymphadenopathy) is a rare entity with ophthalmic manifestations in 11% of patients. Orbital and eyelid involvement as the presenting features is even more unusual. METHODS: The authors report the clinical findings of a 41-year-old man with Rosai-Dorfman disease presenting as eyelid edema. Biopsy of the involved tissue was analyzed by light microscopy. RESULTS: Histologically the orbicularis muscle contained a patchy infiltrate of lymphocytes, plasma cells, and large pale histiocytes. The histiocytes had lymphocytes within them, a condition referred to as lymphocytophagocytosis. CONCLUSIONS: Rosai-Dorfman disease is a rare clinical entity that may occasionally manifest with eyelid edema. Biopsy reveals a characteristic histopathologic picture.
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