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  • Title: Effects of metformin on fibrinogen levels in obese patients with type 2 diabetes.
    Author: Fanghänel G, Silva U, Sanchez-Reyes L, Sisson D, Sotres D, Torres EM.
    Journal: Rev Invest Clin; 1998; 50(5):389-94. PubMed ID: 9949668.
    Abstract:
    OBJECTIVE: To determine fibrinogen levels in obese patients with type 2 diabetes and assess its changes with the use of metformin. METHODS: 60 obese patients (BMI > 27) with type 2 diabetes were studied in an open, two phase, prospective, randomized and comparative study. The pre-treatment phase was a period of four weeks of a controlled diet. In the treatment phase they were divided in two subgroups of 30. One received metformin as a daily single tablet of 850 mg and increasing the dosage to two or three tablets depending on their metabolic control. The second subgroup received 24 units of DNA-recombinant insulin subcutaneously (two thirds of dose before breakfast, and the remaining third before dinner). The insulin dosage was adjusted according to the metabolic response. A control group was formed by 60 non diabetic obese patients with only the controlled diet. RESULTS: The mean values of plasma glucose, fibrinogen levels and body mass index did not change in the pretreatment phase in controls and diabetics. These parameters decreased significantly in the metformin subgroup in the treatment phase (p < 0.001). Only glucose decreased in the insulin subgroup. There were no changes in the controls. CONCLUSIONS: In addition to improving metabolic control, metformin showed to be a good therapeutic alternative in modifying fibrinogen levels in type 2 diabetic patients.
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