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  • Title: [Treatment of diabetes insipidus with Minirin. Switch from nasal to oral administration].
    Author: Czernichow P.
    Journal: Ann Endocrinol (Paris); 1998 Dec; 59(5):407-9. PubMed ID: 9949892.
    Abstract:
    DDAVP (desmopressin, Minirin is now available in tablet form. We studied the switch from nasal to oral administration in patients taking DDAVP for diabetes insipidis. A retrospective analysis included 56 patients. Mean nasal dosage was found to be 20.4 micrograms desmopressin and mean oral dosage was 417 micrograms. This gave a dosage ratio of about 20, in agreement with current data on the drug's bioavailability. In addition, the daily dose was fractioned more often with oral administration than with nasal administration. This study prepares the way for a prospective study needed to better define the conditions for oral administration of DDAVP (Minirin).
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