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  • Title: [The role of hyperplasia of the arterial intima in human atherogenesis].
    Author: Zhdanov VS.
    Journal: Arkh Patol; 1998; 60(6):8-13. PubMed ID: 9949897.
    Abstract:
    Arteries predisposed and resistant to atherosclerosis development were studied. Arteries predisposed to atherosclerosis show a high degree of intima hyperplasia and various alterations of elastic structures. Hyperplasia of the vascular intima followed by disturbance of plasma perfusion through the arterial wall and increase of its cellularity (lymphocytes, monocytes/macrophages) determines possibility of atherosclerosis development (crucial factor of atherosclerosis pathogenesis) in man. Accumulation of lipids in the intima occurs not only in pronounced disturbances of lipid metabolism but at its "normal" indices as well this resulting in atherosclerosis development in all members of the population.
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