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  • Title: [Treatment of type 2 diabetes. Early detection of secondary oral treatment failure is important].
    Author: Clauson P, Efendic S.
    Journal: Lakartidningen; 1999 Jan 20; 96(3):176-81. PubMed ID: 9951232.
    Abstract:
    As type II diabetes is caused by decreased insulin secretion and increased insulin resistance, treatment must be aimed at the correction of these abnormalities. To this end, oral hypoglycaemic agents (OHAs) are used once adverse lifestyle factors have been suitably modified. New OHAs are being developed, or have already been approved. Subsequent treatment failure, after an initially satisfactory response, occurs in 5-10 per cent of patients on OHAs, and is currently treated with a combination of an OHA for daytime use and NPH insulin (isophane insulin) for use at bedtime. This yields metabolic control at least as good as that obtained with intensive insulin treatment, and at less risk of weight gain.
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