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  • Title: [The clinical significance of granulocyte colonies in bone marrow cultures].
    Author: Odavić R, Beck EA, Bucher U.
    Journal: Schweiz Med Wochenschr; 1976 May 29; 106(22):743-5. PubMed ID: 996492.
    Abstract:
    The culture system for in vitro evaluation of "colony forming units - culture (CFU-c)" is briefly outlined. This method offers a new approach to studies of proliferation and differentiation of hemopoietic progenitor cells, especially in disorders of granulopoiesis. From available published data it is evident that quantitation of CFU-c is also an indicator of diagnostic and prognostic value for assessment of various types of leukemia. The CFU-c assay has furthermore been introduced to test the viability and proliferating capacity of cryopreserved bone marrow, especially with a view to possible transfusion of stored autologous bone marrow as an adjuvant to cytostatic therapy.
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