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  • Title: L-fucose metabolism in cystic fibrosis fibroblasts.
    Author: Novak RA, Abell CW.
    Journal: Tex Rep Biol Med; 1976; 34(1):199-207. PubMed ID: 996789.
    Abstract:
    The capacity of skin fibroblasts from cystic fibrosis (CF) and non-CF individuals to incorporate exogenous L-fucose into various metabolic pools was compared. Incorporation into intracellular acid-soluble pools and extracellular glycopeptides was measured by a dual-label co-chromatographic technique, whereas total macromolecular incorporation was measured by a single-label procedure. Although CF and normal fibroblasts incorporate exogenous fucose into intracellular acid-soluble and high molecular weight compounds in a similar manner, CF cells appear to be characterized by an increased incorporation of label into low molecular weight extracellular glycopeptides.
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