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  • Title: Trisomy 7 and trisomy 8 in dividing and non-dividing tumor cells in Dupuytren's disease.
    Author: Dal Cin P, De Smet L, Sciot R, Van Damme B, Van den Berghe H.
    Journal: Cancer Genet Cytogenet; 1999 Jan 15; 108(2):137-40. PubMed ID: 9973941.
    Abstract:
    Cytogenetic and molecular cytogenetic analysis is reported in a series of 40 tissue samples from 36 patients with Dupuytren's disease, presenting as palmar and/or finger nodules. No consistent structural chromosome changes could be found. Instead, recurrent clonal numerical abnormalities were demonstrated in 22 of 40 tissue nodules, involving trisomies of chromosome 7 or 8 and loss of the Y chromosome. In addition, we showed that trisomy 7 and trisomy 8 were also present in non-dividing cells.
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