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  • Title: [The use of ketamine in an experimental model of generalized cerebral ischemia].
    Author: Vasilev D, Konstantinov S, Konstantinova Zh, Nachkov Ia, Karaivanova M, Stamenova P.
    Journal: Khirurgiia (Sofiia); 1998; 51(3):36-9. PubMed ID: 9974025.
    Abstract:
    Thus far, a sufficiently effective cerebroprotective substances has not been discovered. Glutamate overproduction plays a key role in ischemic brain lesion. Ketamine is assigned to the group of commonly used clinical anesthetics, being also familiar as NMDA antagonist. Sodium fluoride-induced cerebral ischemia in mice is used as a model of circulatory ischemic lesion. As shown by the experimental data, simultaneous administration of NaF + ketamine has no effect whatsoever on the survivorship of animals, as compared to that in the control group treated with NaF alone. Beforehand treatment of mice with 150 mg/kg ketamine brings about considerable prolongation of the survival term (15 per cent of the animals survive for more than 2 hours). The inference is reached that ketamine is endowed with cerebroprotective activity largely attributable to glutamate antagonism at the level of ischemia involved neurons.
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