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  • Title: [Prostaglandins compared with oxytocin for induction of labour at term (author's transl)].
    Author: Seidl A, Stopfer H, Gruber W, Fröhlich H, Baumgarten K.
    Journal: Wien Klin Wochenschr; 1976 May 14; 88(10):315-8. PubMed ID: 997522.
    Abstract:
    12 cases of induction of labour with prostaglandin F2 alpha and 8 with prostaglandin E2 were compared with 14 cases in which induction was undertaken with oxytocin. All inductions were successful, the induction--delivery intervals being slightly shorter in the prostaglandin groups than in the oxytocin group. Both with prostaglandin F2 alpha and with prostaglandin E2 the cardiotocogram showed uterine hyperactivity in most of the cases with an unexpected, episodically-occurring increase in basal uterine tone and remarkable tachysystoly. Uterine hyper-activity led to fetal heart rate alterations of the "dip 2" type in about 50% of the cases. According to these results prostaglandins cannot be considered superior to oxytocin for the induction of labour at term.
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