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  • Title: The effect of perphenazine treatment during the organogenesis in rats.
    Author: Druga A.
    Journal: Acta Biol Acad Sci Hung; 1976; 27(1):15-23. PubMed ID: 998109.
    Abstract:
    The teratogenic effect of perphenazine was studied in closed-bred Wistar rats. Rats were given the substance orally continuously on days 7 to 14 of pregnancy, or as a single dose on one of days 9-15. The doses were considerably higher than the specific neuroleptic doses of perphenazine (20-150 mg/kg). The fetal mortality and malformation rates were significantly higher in the perphenazine-treated groups than in the controls. The results were compared with the earlier results of methophenazine treatment. Perphenazine was found to be more toxic for rat embryos than methophenazine.
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