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  • Title: The intramitochondrial ATP/ADP-ratio controls cytochrome c oxidase activity allosterically.
    Author: Arnold S, Kadenbach B.
    Journal: FEBS Lett; 1999 Jan 25; 443(2):105-8. PubMed ID: 9989584.
    Abstract:
    Recently the signal transduction function for oxidative phosphorylation was found to be second order in ADP [Jeneson, J.A.L., Wiseman, R.W., Westerhoff, H.V. and Kushmerick, M.J. (1996) J. Biol. Chem. 271, 27995-279981, but the molecular mechanism of signal transduction remained unclear. Previously we described inhibition of cytochrome c oxidase by intramitochondrial ATP, accompanied by a change of hyperbolic into sigmoidal kinetics. The present study describes a sigmoidal relationship also between the ascorbate respiration of reconstituted cytochrome c oxidase and intraliposomal ADP concentration. Its possible role in the control of oxidative phosphorylation and cell respiration is discussed.
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