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  • Title: Platelet glycoprotein IIb/IIIa receptor antagonists derived from isoxazolidines.
    Author: Confalone PN, Jin F, Mousa SA.
    Journal: Bioorg Med Chem Lett; 1999 Jan 04; 9(1):55-8. PubMed ID: 9990456.
    Abstract:
    A series of isoxazolidines has been synthesized as mimetics of the RGD sequence and was evaluated as antagonists of the platelet glycoprotein IIb/IIIa receptor. These compounds were shown to be highly potent GPIIb/IIIa antagonists, exhibiting submicromolar potencies.
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