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  • Title: 2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.
    Author: Imbach P, Capraro HG, Furet P, Mett H, Meyer T, Zimmermann J.
    Journal: Bioorg Med Chem Lett; 1999 Jan 04; 9(1):91-6. PubMed ID: 9990463.
    Abstract:
    Novel 2,6,9-substituted purine derivatives represent a class of potent and selective inhibitors of CDK1/cyclinB. The synthesis, SAR and biological profile of selected compounds are described.
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