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  • Title: Azaindole derivatives with high affinity for the dopamine D4 receptor: synthesis, ligand binding studies and comparison of molecular electrostatic potential maps.
    Author: Löber S, Hübner H, Gmeiner P.
    Journal: Bioorg Med Chem Lett; 1999 Jan 04; 9(1):97-102. PubMed ID: 9990464.
    Abstract:
    Piperazinylmethyl substituted pyrazolo[1,5-a]pyridines and related heterocycles were synthesized and found to recognize selectively the dopamine D4 receptor. For the most potent derivative 10d a Ki value of 2.0 nM was observed. SAR studies including the comparison of molecular isopotential surfaces were performed.
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