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  • Title: Reduction of motoric agitation and restlessness by AF102B and tacrine in the macaque.
    Author: Fitten LJ, Ortiz F, Siembieda DW, O'Neill J, Halgren E, Fisher A.
    Journal: J Neuropsychiatry Clin Neurosci; 1999; 11(1):79-85. PubMed ID: 9990560.
    Abstract:
    The cholinesterase inhibitor tacrine (THA) and the M1 muscarinic agonist AF102B (cevimeline), both reported to enhance cognition in animals and humans, were tested in 5 macaques for reduction of spontaneous, random movements. Monkeys were videotaped 1 hour after administration of normal saline vehicle, after low- and high-dose intramuscular AF102B, and after low- and high-dose oral THA. Two independent blind judges counted numbers of spontaneous movements made by each monkey over 12 consecutive 15-second segments for each drug condition. Both THA and AF102B reduced movement significantly at high doses without overt side effects, warranting further research on the agitation-reducing potential of cognition-enhancing cholinomimetic drugs.
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