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  • Title: Light and electron microscopic examination of exocrine pancreas using zinc iodide-osmium tetroxide technique.
    Author: Atilla P, Akkuş M, Deveci E, Bilgin Y, Inalöz S, Dağdeviren A.
    Journal: Okajimas Folia Anat Jpn; 1998 Dec; 75(5):247-50. PubMed ID: 9990812.
    Abstract:
    Zinc iodide-osmium tetroxide (ZIO) fixation/staining technique is a metallophilic technique which has been used for the examination of various tissues and cell types. We examined the ZIO (+) cell types in rat exocrine pancreas to obtain further evidence for the significance of the reaction. Among mostly non-reactive pancreatic acinar cells there were ZIO (+) acinar cells of varying staining intensity. Zymogenic granules and centroacinar cells were completely non-reactive. Our electron microscopic findings support the view that the reactivity of the technique used is cell specific but not cell type or organelle specific.
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