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  • Title: Auditory-nerve activity in cats exposed to ototoxic drugs and high-intensity sounds.
    Author: Kiang NY, Liberman MC, Levine RA.
    Journal: Ann Otol Rhinol Laryngol; 1976; 85(6 PT. 1):752-68. PubMed ID: 999140.
    Abstract:
    The response characteristics of auditory-nerve fibers in normal cats are compared with those in cats exposed to kanamycin and high-intensity sounds. The pathophysiology is characterized by an elevation of the tuning-curve "tips," which is sometimes associated with hypersensitivity of the "tails". Plots of unit thresholds are correlated with patterns of sensory-cell losses in the cochlea. There can be significant shifts in unit threshold without significant loss of hair cells; however, significant hair cell loss is always accompanied by highly abnormal unit thresholds. The presence of inner hair cells seems to be essential for the long-term survival of spiral ganglion cells. An incidental observation is that in the "normal" animal there is almost always a prominent "notch" at 3-4 kHz in the plots of threshold at characteristic frequency, which may have been produced by environmental noise.
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