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241 related items for PubMed ID: 10021418

  • 1. Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase.
    Gokhale RS, Hunziker D, Cane DE, Khosla C.
    Chem Biol; 1999 Feb; 6(2):117-25. PubMed ID: 10021418
    [Abstract] [Full Text] [Related]

  • 2. Expression and kinetic analysis of the substrate specificity of modules 5 and 6 of the picromycin/methymycin polyketide synthase.
    Yin Y, Lu H, Khosla C, Cane DE.
    J Am Chem Soc; 2003 May 14; 125(19):5671-6. PubMed ID: 12733905
    [Abstract] [Full Text] [Related]

  • 3. Dissecting the role of acyltransferase domains of modular polyketide synthases in the choice and stereochemical fate of extender units.
    Lau J, Fu H, Cane DE, Khosla C.
    Biochemistry; 1999 Feb 02; 38(5):1643-51. PubMed ID: 9931032
    [Abstract] [Full Text] [Related]

  • 4. Elucidating the mechanism of chain termination switching in the picromycin/methymycin polyketide synthase.
    Tang L, Fu H, Betlach MC, McDaniel R.
    Chem Biol; 1999 Aug 02; 6(8):553-8. PubMed ID: 10421766
    [Abstract] [Full Text] [Related]

  • 5. Purification and characterization of bimodular and trimodular derivatives of the erythromycin polyketide synthase.
    Pieper R, Gokhale RS, Luo G, Cane DE, Khosla C.
    Biochemistry; 1997 Feb 18; 36(7):1846-51. PubMed ID: 9048569
    [Abstract] [Full Text] [Related]

  • 6. A model of structure and catalysis for ketoreductase domains in modular polyketide synthases.
    Reid R, Piagentini M, Rodriguez E, Ashley G, Viswanathan N, Carney J, Santi DV, Hutchinson CR, McDaniel R.
    Biochemistry; 2003 Jan 14; 42(1):72-9. PubMed ID: 12515540
    [Abstract] [Full Text] [Related]

  • 7. Mechanistic analysis of acyl transferase domain exchange in polyketide synthase modules.
    Hans M, Hornung A, Dziarnowski A, Cane DE, Khosla C.
    J Am Chem Soc; 2003 May 07; 125(18):5366-74. PubMed ID: 12720450
    [Abstract] [Full Text] [Related]

  • 8. Molecular basis of Celmer's rules: the role of two ketoreductase domains in the control of chirality by the erythromycin modular polyketide synthase.
    Holzbaur IE, Harris RC, Bycroft M, Cortes J, Bisang C, Staunton J, Rudd BA, Leadlay PF.
    Chem Biol; 1999 Apr 07; 6(4):189-95. PubMed ID: 10099131
    [Abstract] [Full Text] [Related]

  • 9. Origin of starter units for erythromycin biosynthesis.
    Weissman KJ, Bycroft M, Staunton J, Leadlay PF.
    Biochemistry; 1998 Aug 04; 37(31):11012-7. PubMed ID: 9692995
    [Abstract] [Full Text] [Related]

  • 10. Erythromycin biosynthesis: kinetic studies on a fully active modular polyketide synthase using natural and unnatural substrates.
    Pieper R, Ebert-Khosla S, Cane D, Khosla C.
    Biochemistry; 1996 Feb 20; 35(7):2054-60. PubMed ID: 8652546
    [Abstract] [Full Text] [Related]

  • 11. Identification of domains within megalomicin and erythromycin polyketide synthase modules responsible for differences in polyketide production levels in Escherichia coli.
    Murli S, Piagentini M, McDaniel R, Hutchinson CR.
    Biochemistry; 2004 Dec 21; 43(50):15884-90. PubMed ID: 15595843
    [Abstract] [Full Text] [Related]

  • 12. Analysis of the enzymatic domains in the modular portion of the coronafacic acid polyketide synthase.
    Jiralerspong S, Rangaswamy V, Bender CL, Parry RJ.
    Gene; 2001 May 30; 270(1-2):191-200. PubMed ID: 11404016
    [Abstract] [Full Text] [Related]

  • 13. Towards a characterization of the structural determinants of specificity in the macrocyclizing thioesterase for deoxyerythronolide B biosynthesis.
    Argyropoulos P, Bergeret F, Pardin C, Reimer JM, Pinto A, Boddy CN, Schmeing TM.
    Biochim Biophys Acta; 2016 Mar 30; 1860(3):486-97. PubMed ID: 26592346
    [Abstract] [Full Text] [Related]

  • 14. Quantitative analysis of loading and extender acyltransferases of modular polyketide synthases.
    Liou GF, Lau J, Cane DE, Khosla C.
    Biochemistry; 2003 Jan 14; 42(1):200-7. PubMed ID: 12515555
    [Abstract] [Full Text] [Related]

  • 15. Mechanisms of molecular recognition in the pikromycin polyketide synthase.
    Chen S, Xue Y, Sherman DH, Reynolds KA.
    Chem Biol; 2000 Dec 14; 7(12):907-18. PubMed ID: 11137814
    [Abstract] [Full Text] [Related]

  • 16. Examining the role of hydrogen bonding interactions in the substrate specificity for the loading step of polyketide synthase thioesterase domains.
    Wang M, Boddy CN.
    Biochemistry; 2008 Nov 11; 47(45):11793-803. PubMed ID: 18850723
    [Abstract] [Full Text] [Related]

  • 17. Enhancing the modularity of the modular polyketide synthases: transacylation in modular polyketide synthases catalyzed by malonyl-CoA:ACP transacylase.
    Kumar P, Koppisch AT, Cane DE, Khosla C.
    J Am Chem Soc; 2003 Nov 26; 125(47):14307-12. PubMed ID: 14624579
    [Abstract] [Full Text] [Related]

  • 18. Covalent linkage mediates communication between ACP and TE domains in modular polyketide synthases.
    Tran L, Tosin M, Spencer JB, Leadlay PF, Weissman KJ.
    Chembiochem; 2008 Apr 14; 9(6):905-15. PubMed ID: 18348128
    [Abstract] [Full Text] [Related]

  • 19. The acyltransferase homologue from the initiation module of the R1128 polyketide synthase is an acyl-ACP thioesterase that edits acetyl primer units.
    Tang Y, Koppisch AT, Khosla C.
    Biochemistry; 2004 Jul 27; 43(29):9546-55. PubMed ID: 15260498
    [Abstract] [Full Text] [Related]

  • 20. Ketosynthases in the initiation and elongation modules of aromatic polyketide synthases have orthogonal acyl carrier protein specificity.
    Tang Y, Lee TS, Kobayashi S, Khosla C.
    Biochemistry; 2003 Jun 03; 42(21):6588-95. PubMed ID: 12767243
    [Abstract] [Full Text] [Related]

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