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Journal Abstract Search


166 related items for PubMed ID: 10037473

  • 1. Increased vulnerability of hippocampal neurons from presenilin-1 mutant knock-in mice to amyloid beta-peptide toxicity: central roles of superoxide production and caspase activation.
    Guo Q, Sebastian L, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP.
    J Neurochem; 1999 Mar; 72(3):1019-29. PubMed ID: 10037473
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  • 3. Superoxide mediates the cell-death-enhancing action of presenilin-1 mutations.
    Guo Q, Fu W, Holtsberg FW, Steiner SM, Mattson MP.
    J Neurosci Res; 1999 Jun 01; 56(5):457-70. PubMed ID: 10369213
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  • 5. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
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  • 6. Presenilin-1 P264L knock-in mutation: differential effects on abeta production, amyloid deposition, and neuronal vulnerability.
    Siman R, Reaume AG, Savage MJ, Trusko S, Lin YG, Scott RW, Flood DG.
    J Neurosci; 2000 Dec 01; 20(23):8717-26. PubMed ID: 11102478
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  • 7. Mutations in amyloid precursor protein and presenilin-1 genes increase the basal oxidative stress in murine neuronal cells and lead to increased sensitivity to oxidative stress mediated by amyloid beta-peptide (1-42), HO and kainic acid: implications for Alzheimer's disease.
    Mohmmad Abdul H, Sultana R, Keller JN, St Clair DK, Markesbery WR, Butterfield DA.
    J Neurochem; 2006 Mar 01; 96(5):1322-35. PubMed ID: 16478525
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  • 8. Aberrant induction of Par-4 is involved in apoptosis of hippocampal neurons in presenilin-1 M146V mutant knock-in mice.
    Xie J, Chang X, Zhang X, Guo Q.
    Brain Res; 2001 Oct 05; 915(1):1-10. PubMed ID: 11578614
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  • 9. Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.
    Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP.
    Nat Med; 1999 Jan 05; 5(1):101-6. PubMed ID: 9883847
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  • 10. Presenilin-1 mutation increases neuronal vulnerability to focal ischemia in vivo and to hypoxia and glucose deprivation in cell culture: involvement of perturbed calcium homeostasis.
    Mattson MP, Zhu H, Yu J, Kindy MS.
    J Neurosci; 2000 Feb 15; 20(4):1358-64. PubMed ID: 10662826
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  • 11. Alzheimer's presenilin mutation sensitizes neural cells to apoptosis induced by trophic factor withdrawal and amyloid beta-peptide: involvement of calcium and oxyradicals.
    Guo Q, Sopher BL, Furukawa K, Pham DG, Robinson N, Martin GM, Mattson MP.
    J Neurosci; 1997 Jun 01; 17(11):4212-22. PubMed ID: 9151738
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  • 12. Alzheimer's disease-like alterations in peripheral cells from presenilin-1 transgenic mice.
    Eckert A, Schindowski K, Leutner S, Luckhaus C, Touchet N, Czech C, Müller WE.
    Neurobiol Dis; 2001 Apr 01; 8(2):331-42. PubMed ID: 11300728
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  • 13. Dietary restriction protects hippocampal neurons against the death-promoting action of a presenilin-1 mutation.
    Zhu H, Guo Q, Mattson MP.
    Brain Res; 1999 Sep 18; 842(1):224-9. PubMed ID: 10526115
    [Abstract] [Full Text] [Related]

  • 14. Increased sensitivity to mitochondrial toxin-induced apoptosis in neural cells expressing mutant presenilin-1 is linked to perturbed calcium homeostasis and enhanced oxyradical production.
    Keller JN, Guo Q, Holtsberg FW, Bruce-Keller AJ, Mattson MP.
    J Neurosci; 1998 Jun 15; 18(12):4439-50. PubMed ID: 9614221
    [Abstract] [Full Text] [Related]

  • 15. Presenilin-1 mutations increase levels of ryanodine receptors and calcium release in PC12 cells and cortical neurons.
    Chan SL, Mayne M, Holden CP, Geiger JD, Mattson MP.
    J Biol Chem; 2000 Jun 16; 275(24):18195-200. PubMed ID: 10764737
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  • 16. Caspase-2 mediates neuronal cell death induced by beta-amyloid.
    Troy CM, Rabacchi SA, Friedman WJ, Frappier TF, Brown K, Shelanski ML.
    J Neurosci; 2000 Feb 15; 20(4):1386-92. PubMed ID: 10662829
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  • 17. Adverse effect of a presenilin-1 mutation in microglia results in enhanced nitric oxide and inflammatory cytokine responses to immune challenge in the brain.
    Lee J, Chan SL, Mattson MP.
    Neuromolecular Med; 2002 Feb 15; 2(1):29-45. PubMed ID: 12230303
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  • 18. Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.
    Pigino G, Pelsman A, Mori H, Busciglio J.
    J Neurosci; 2001 Feb 01; 21(3):834-42. PubMed ID: 11157069
    [Abstract] [Full Text] [Related]

  • 19. Reactive oxidative species enhance amyloid toxicity in APP/PS1 mouse neurons.
    Yang B, Sun X, Lashuel H, Zhang Y.
    Neurosci Bull; 2012 Jun 01; 28(3):233-9. PubMed ID: 22622822
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  • 20. Enhancement of activation of caspases by presenilin 1 gene mutations and its inhibition by secretase inhibitors.
    Miyoshi K, Ohyagi Y, Sakae N, Motomura K, Ma L, Taniwaki T, Furuya H, Tabira T, Kira J.
    J Alzheimers Dis; 2009 Jun 01; 16(3):551-64. PubMed ID: 19276550
    [Abstract] [Full Text] [Related]


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