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Journal Abstract Search

665 related items for PubMed ID: 10064567

  • 1. Studies on cytochrome P-450-mediated bioactivation of diclofenac in rats and in human hepatocytes: identification of glutathione conjugated metabolites.
    Tang W, Stearns RA, Bandiera SM, Zhang Y, Raab C, Braun MP, Dean DC, Pang J, Leung KH, Doss GA, Strauss JR, Kwei GY, Rushmore TH, Chiu SH, Baillie TA.
    Drug Metab Dispos; 1999 Mar; 27(3):365-72. PubMed ID: 10064567
    [Abstract] [Full Text] [Related]

  • 2. Roles of human hepatic cytochrome P450s 2C9 and 3A4 in the metabolic activation of diclofenac.
    Tang W, Stearns RA, Wang RW, Chiu SH, Baillie TA.
    Chem Res Toxicol; 1999 Feb; 12(2):192-9. PubMed ID: 10027798
    [Abstract] [Full Text] [Related]

  • 3. A novel bioactivation pathway for 2-[2-(2,6-dichlorophenyl)aminophenyl]ethanoic acid (diclofenac) initiated by cytochrome P450-mediated oxidative decarboxylation.
    Grillo MP, Ma J, Teffera Y, Waldon DJ.
    Drug Metab Dispos; 2008 Sep; 36(9):1740-4. PubMed ID: 18541695
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  • 5. Metabolic activation of diclofenac by human cytochrome P450 3A4: role of 5-hydroxydiclofenac.
    Shen S, Marchick MR, Davis MR, Doss GA, Pohl LR.
    Chem Res Toxicol; 1999 Feb; 12(2):214-22. PubMed ID: 10027801
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  • 6. Metabolism and bioactivation of 3-methylindole by human liver microsomes.
    Yan Z, Easterwood LM, Maher N, Torres R, Huebert N, Yost GS.
    Chem Res Toxicol; 2007 Jan; 20(1):140-8. PubMed ID: 17226936
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  • 7. Identification of a novel glutathione adduct of diclofenac, 4'-hydroxy-2'-glutathion-deschloro-diclofenac, upon incubation with human liver microsomes.
    Yu LJ, Chen Y, Deninno MP, O'Connell TN, Hop CE.
    Drug Metab Dispos; 2005 Apr; 33(4):484-8. PubMed ID: 15640374
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  • 8. Interaction of diclofenac and quinidine in monkeys: stimulation of diclofenac metabolism.
    Tang W, Stearns RA, Kwei GY, Iliff SA, Miller RR, Egan MA, Yu NX, Dean DC, Kumar S, Shou M, Lin JH, Baillie TA.
    J Pharmacol Exp Ther; 1999 Dec; 291(3):1068-74. PubMed ID: 10565826
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  • 10. Metabolism of the chemoprotective agent diallyl sulfide to glutathione conjugates in rats.
    Jin L, Baillie TA.
    Chem Res Toxicol; 1997 Mar; 10(3):318-27. PubMed ID: 9084912
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  • 13. Differences in cytochrome P450-mediated biotransformation of 1,2-dichlorobenzene by rat and man: implications for human risk assessment.
    Hissink AM, Oudshoorn MJ, Van Ommen B, Haenen GR, Van Bladeren PJ.
    Chem Res Toxicol; 1996 Dec; 9(8):1249-56. PubMed ID: 8951226
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  • 15. Cytochrome P4502C11 is a target of diclofenac covalent binding in rats.
    Shen S, Hargus SJ, Martin BM, Pohl LR.
    Chem Res Toxicol; 1997 Apr; 10(4):420-3. PubMed ID: 9114979
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  • 16. In vitro metabolism of L-696,229, an HIV-1 reverse transcriptase inhibitor in rats and humans. Hepatic and extrahepatic metabolism and identification of enzymes involved in the hepatic metabolism.
    Prueksaritanont T, Dwyer LM, Balani SK, Theoharides AD.
    Drug Metab Dispos; 1994 Apr; 22(2):281-8. PubMed ID: 7516854
    [Abstract] [Full Text] [Related]

  • 17. Bioactivation of flutamide metabolites by human liver microsomes.
    Kang P, Dalvie D, Smith E, Zhou S, Deese A, Nieman JA.
    Drug Metab Dispos; 2008 Jul; 36(7):1425-37. PubMed ID: 18411402
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  • 18. Detection of a novel reactive metabolite of diclofenac: evidence for CYP2C9-mediated bioactivation via arene oxides.
    Yan Z, Li J, Huebert N, Caldwell GW, Du Y, Zhong H.
    Drug Metab Dispos; 2005 Jun; 33(6):706-13. PubMed ID: 15764717
    [Abstract] [Full Text] [Related]

  • 19. Metabolism of prazosin in rat, dog, and human liver microsomes and cryopreserved rat and human hepatocytes and characterization of metabolites by liquid chromatography/tandem mass spectrometry.
    Erve JC, Vashishtha SC, DeMaio W, Talaat RE.
    Drug Metab Dispos; 2007 Jun; 35(6):908-16. PubMed ID: 17353349
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  • 20. Elucidation of a novel bioactivation pathway of a 3,4-unsubstituted isoxazole in human liver microsomes: formation of a glutathione adduct of a cyanoacrolein derivative after isoxazole ring opening.
    Yu J, Folmer JJ, Hoesch V, Doherty J, Campbell JB, Burdette D.
    Drug Metab Dispos; 2011 Feb; 39(2):302-11. PubMed ID: 21045198
    [Abstract] [Full Text] [Related]

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