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Journal Abstract Search

771 related items for PubMed ID: 10197959

  • 1. Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 1. Thiazolone and oxazolone series.
    Song Y, Connor DT, Doubleday R, Sorenson RJ, Sercel AD, Unangst PC, Roth BD, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD.
    J Med Chem; 1999 Apr 08; 42(7):1151-60. PubMed ID: 10197959
    [Abstract] [Full Text] [Related]

  • 2. Synthesis, structure-activity relationships, and in vivo evaluations of substituted di-tert-butylphenols as a novel class of potent, selective, and orally active cyclooxygenase-2 inhibitors. 2. 1,3,4- and 1,2,4-thiadiazole series.
    Song Y, Connor DT, Sercel AD, Sorenson RJ, Doubleday R, Unangst PC, Roth BD, Beylin VG, Gilbertsen RB, Chan K, Schrier DJ, Guglietta A, Bornemeier DA, Dyer RD.
    J Med Chem; 1999 Apr 08; 42(7):1161-9. PubMed ID: 10197960
    [Abstract] [Full Text] [Related]

  • 3. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
    Riendeau D, Percival MD, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Falgueyret JP, Ford-Hutchinson AW, Gordon R, Greig G, Gresser M, Guay J, Kargman S, Léger S, Mancini JA, O'Neill G, Ouellet M, Rodger IW, Thérien M, Wang Z, Webb JK, Wong E, Chan CC.
    Br J Pharmacol; 1997 May 08; 121(1):105-17. PubMed ID: 9146894
    [Abstract] [Full Text] [Related]

  • 4. Amide derivatives of [5-chloro-6-(2-chloro/fluorobenzoyl)-2-benzoxazolinone-3-yl]acetic acids as potential analgesic and anti-inflammatory compounds.
    Banoglu E, Okçelik B, Kupeli E, Unlü S, Yeşilada E, Amat M, Caturla JF, Sahin MF.
    Arch Pharm (Weinheim); 2003 Jul 08; 336(4-5):251-7. PubMed ID: 12916060
    [Abstract] [Full Text] [Related]

  • 5. Covalent modification of cyclooxygenase-2 (COX-2) by 2-acetoxyphenyl alkyl sulfides, a new class of selective COX-2 inactivators.
    Kalgutkar AS, Kozak KR, Crews BC, Hochgesang GP, Marnett LJ.
    J Med Chem; 1998 Nov 19; 41(24):4800-18. PubMed ID: 9822550
    [Abstract] [Full Text] [Related]

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  • 7. 1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2.
    Khanna IK, Weier RM, Yu Y, Collins PW, Miyashiro JM, Koboldt CM, Veenhuizen AW, Currie JL, Seibert K, Isakson PC.
    J Med Chem; 1997 May 23; 40(11):1619-33. PubMed ID: 9171872
    [Abstract] [Full Text] [Related]

  • 8. New cyclooxygenase-2/5-lipoxygenase inhibitors. 3. 7-tert-butyl-2, 3-dihydro-3,3-dimethylbenzofuran derivatives as gastrointestinal safe antiinflammatory and analgesic agents: variations at the 5 position.
    Janusz JM, Young PA, Ridgeway JM, Scherz MW, Enzweiler K, Wu LI, Gan L, Chen J, Kellstein DE, Green SA, Tulich JL, Rosario-Jansen T, Magrisso IJ, Wehmeyer KR, Kuhlenbeck DL, Eichhold TH, Dobson RL.
    J Med Chem; 1998 Aug 27; 41(18):3515-29. PubMed ID: 9719605
    [Abstract] [Full Text] [Related]

  • 9. Design, synthesis, and biological evaluation of 6-substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.
    Praveen Rao PN, Amini M, Li H, Habeeb AG, Knaus EE.
    J Med Chem; 2003 Nov 06; 46(23):4872-82. PubMed ID: 14584938
    [Abstract] [Full Text] [Related]

  • 10. Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
    Chan CC, Boyce S, Brideau C, Charleson S, Cromlish W, Ethier D, Evans J, Ford-Hutchinson AW, Forrest MJ, Gauthier JY, Gordon R, Gresser M, Guay J, Kargman S, Kennedy B, Leblanc Y, Leger S, Mancini J, O'Neill GP, Ouellet M, Patrick D, Percival MD, Perrier H, Prasit P, Rodger I.
    J Pharmacol Exp Ther; 1999 Aug 06; 290(2):551-60. PubMed ID: 10411562
    [Abstract] [Full Text] [Related]

  • 11. ABT-963 [2-(3,4-difluoro-phenyl)-4-(3-hydroxy-3-methyl-butoxy)-5-(4-methanesulfonyl-phenyl)-2H-pyridazin-3-one], a highly potent and selective disubstituted pyridazinone cyclooxgenase-2 inhibitor.
    Harris RR, Black L, Surapaneni S, Kolasa T, Majest S, Namovic MT, Grayson G, Komater V, Wilcox D, King L, Marsh K, Jarvis MF, Nuss M, Nellans H, Pruesser L, Reinhart GA, Cox B, Jacobson P, Stewart A, Coghlan M, Carter G, Bell RL.
    J Pharmacol Exp Ther; 2004 Dec 06; 311(3):904-12. PubMed ID: 15277581
    [Abstract] [Full Text] [Related]

  • 12. 2,3-Diarylcyclopentenones as orally active, highly selective cyclooxygenase-2 inhibitors.
    Black WC, Brideau C, Chan CC, Charleson S, Chauret N, Claveau D, Ethier D, Gordon R, Greig G, Guay J, Hughes G, Jolicoeur P, Leblanc Y, Nicoll-Griffith D, Ouimet N, Riendeau D, Visco D, Wang Z, Xu L, Prasit P.
    J Med Chem; 1999 Apr 08; 42(7):1274-81. PubMed ID: 10197970
    [Abstract] [Full Text] [Related]

  • 13. Effects of novel anti-inflammatory compounds on healing of acetic acid-induced gastric ulcer in rats.
    Lesch CA, Gilbertsen RB, Song Y, Dyer RD, Schrier D, Kraus ER, Sanchez B, Guglietta A.
    J Pharmacol Exp Ther; 1998 Oct 08; 287(1):301-6. PubMed ID: 9765350
    [Abstract] [Full Text] [Related]

  • 14. 1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.
    Khanna IK, Weier RM, Yu Y, Xu XD, Koszyk FJ, Collins PW, Koboldt CM, Veenhuizen AW, Perkins WE, Casler JJ, Masferrer JL, Zhang YY, Gregory SA, Seibert K, Isakson PC.
    J Med Chem; 1997 May 23; 40(11):1634-47. PubMed ID: 9171873
    [Abstract] [Full Text] [Related]

  • 15. Comparison of the cyclooxygenase-1 inhibitory properties of nonsteroidal anti-inflammatory drugs (NSAIDs) and selective COX-2 inhibitors, using sensitive microsomal and platelet assays.
    Riendeau D, Charleson S, Cromlish W, Mancini JA, Wong E, Guay J.
    Can J Physiol Pharmacol; 1997 Sep 23; 75(9):1088-95. PubMed ID: 9365818
    [Abstract] [Full Text] [Related]

  • 16. Cyclooxygenase-2 selective and nitric oxide-releasing nonsteroidal anti-inflammatory drugs and gastric mucosal responses.
    Takeuchi K, Suzuki K, Yamamoto H, Araki H, Mizoguchi H, Ukawa H.
    J Physiol Pharmacol; 1998 Dec 23; 49(4):501-13. PubMed ID: 10069692
    [Abstract] [Full Text] [Related]

  • 17. Synthesis and structure-activity relationship of a new series of COX-2 selective inhibitors: 1,5-diarylimidazoles.
    Almansa C, Alfón J, de Arriba AF, Cavalcanti FL, Escamilla I, Gómez LA, Miralles A, Soliva R, Bartrolí J, Carceller E, Merlos M, García-Rafanell J.
    J Med Chem; 2003 Jul 31; 46(16):3463-75. PubMed ID: 12877584
    [Abstract] [Full Text] [Related]

  • 18. Design, synthesis, and biological evaluation of N-acetyl-2-(or 3-)carboxymethylbenzenesulfonamides as cyclooxygenase isozyme inhibitors.
    Chen QH, Rao PN, Knaus EE.
    Bioorg Med Chem; 2005 Aug 01; 13(15):4694-703. PubMed ID: 15914011
    [Abstract] [Full Text] [Related]

  • 19. Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.
    Li JJ, Norton MB, Reinhard EJ, Anderson GD, Gregory SA, Isakson PC, Koboldt CM, Masferrer JL, Perkins WE, Seibert K, Zhang Y, Zweifel BS, Reitz DB.
    J Med Chem; 1996 Apr 26; 39(9):1846-56. PubMed ID: 8627608
    [Abstract] [Full Text] [Related]

  • 20. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach.
    Chan CC, Boyce S, Brideau C, Ford-Hutchinson AW, Gordon R, Guay D, Hill RG, Li CS, Mancini J, Penneton M.
    J Pharmacol Exp Ther; 1995 Sep 26; 274(3):1531-7. PubMed ID: 7562530
    [Abstract] [Full Text] [Related]

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