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390 related items for PubMed ID: 10197965

  • 1. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.
    Dragovich PS, Prins TJ, Zhou R, Webber SE, Marakovits JT, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Ford CE, Burke BJ, Rejto PA, Hendrickson TF, Tuntland T, Brown EL, Meador JW, Ferre RA, Harr JE, Kosa MB, Worland ST.
    J Med Chem; 1999 Apr 08; 42(7):1213-24. PubMed ID: 10197965
    [Abstract] [Full Text] [Related]

  • 2. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics.
    Dragovich PS, Prins TJ, Zhou R, Fuhrman SA, Patick AK, Matthews DA, Ford CE, Meador JW, Ferre RA, Worland ST.
    J Med Chem; 1999 Apr 08; 42(7):1203-12. PubMed ID: 10197964
    [Abstract] [Full Text] [Related]

  • 3. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies.
    Dragovich PS, Webber SE, Babine RE, Fuhrman SA, Patick AK, Matthews DA, Reich SH, Marakovits JT, Prins TJ, Zhou R, Tikhe J, Littlefield ES, Bleckman TM, Wallace MB, Little TL, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, DeLisle DM, Worland ST.
    J Med Chem; 1998 Jul 16; 41(15):2819-34. PubMed ID: 9667971
    [Abstract] [Full Text] [Related]

  • 4. Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements.
    Webber SE, Okano K, Little TL, Reich SH, Xin Y, Fuhrman SA, Matthews DA, Love RA, Hendrickson TF, Patick AK, Meador JW, Ferre RA, Brown EL, Ford CE, Binford SL, Worland ST.
    J Med Chem; 1998 Jul 16; 41(15):2786-805. PubMed ID: 9667969
    [Abstract] [Full Text] [Related]

  • 5. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.
    Dragovich PS, Webber SE, Babine RE, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Reich SH, Prins TJ, Marakovits JT, Littlefield ES, Zhou R, Tikhe J, Ford CE, Wallace MB, Meador JW, Ferre RA, Brown EL, Binford SL, Harr JE, DeLisle DM, Worland ST.
    J Med Chem; 1998 Jul 16; 41(15):2806-18. PubMed ID: 9667970
    [Abstract] [Full Text] [Related]

  • 6. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 8. Pharmacological optimization of orally bioavailable 2-pyridone-containing peptidomimetics.
    Dragovich PS, Prins TJ, Zhou R, Johnson TO, Hua Y, Luu HT, Sakata SK, Brown EL, Maldonado FC, Tuntland T, Lee CA, Fuhrman SA, Zalman LS, Patick AK, Matthews DA, Wu EY, Guo M, Borer BC, Nayyar NK, Moran T, Chen L, Rejto PA, Rose PW, Guzman MC, Dovalsantos EZ, Lee S, McGee K, Mohajeri M, Liese A, Tao J, Kosa MB, Liu B, Batugo MR, Gleeson JP, Wu ZP, Liu J, Meador JW, Ferre RA.
    J Med Chem; 2003 Oct 09; 46(21):4572-85. PubMed ID: 14521419
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and evaluation of peptidyl Michael acceptors that inactivate human rhinovirus 3C protease and inhibit virus replication.
    Kong JS, Venkatraman S, Furness K, Nimkar S, Shepherd TA, Wang QM, Aubé J, Hanzlik RP.
    J Med Chem; 1998 Jul 02; 41(14):2579-87. PubMed ID: 9651162
    [Abstract] [Full Text] [Related]

  • 8. Development of potent inhibitors of the coxsackievirus 3C protease.
    Lee ES, Lee WG, Yun SH, Rho SH, Im I, Yang ST, Sellamuthu S, Lee YJ, Kwon SJ, Park OK, Jeon ES, Park WJ, Kim YC.
    Biochem Biophys Res Commun; 2007 Jun 22; 358(1):7-11. PubMed ID: 17485072
    [Abstract] [Full Text] [Related]

  • 9. AG-7088 Pfizer.
    Witherell G.
    Curr Opin Investig Drugs; 2000 Nov 22; 1(3):297-302. PubMed ID: 11249711
    [Abstract] [Full Text] [Related]

  • 10. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 6. Structure-activity studies of orally bioavailable, 2-pyridone-containing peptidomimetics.
    Dragovich PS, Prins TJ, Zhou R, Brown EL, Maldonado FC, Fuhrman SA, Zalman LS, Tuntland T, Lee CA, Patick AK, Matthews DA, Hendrickson TF, Kosa MB, Liu B, Batugo MR, Gleeson JP, Sakata SK, Chen L, Guzman MC, Meador JW, Ferre RA, Worland ST.
    J Med Chem; 2002 Apr 11; 45(8):1607-23. PubMed ID: 11931615
    [Abstract] [Full Text] [Related]

  • 11. Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors.
    Dragovich PS, Zhou R, Webber SE, Prins TJ, Kwok AK, Okano K, Fuhrman SA, Zalman LS, Maldonado FC, Brown EL, Meador JW, Patick AK, Ford CE, Brothers MA, Binford SL, Matthews DA, Ferre RA, Worland ST.
    Bioorg Med Chem Lett; 2000 Jan 03; 10(1):45-8. PubMed ID: 10636240
    [Abstract] [Full Text] [Related]

  • 12. Non-covalent inhibitors of rhinovirus 3C protease.
    Baxter A, Chambers M, Edfeldt F, Edman K, Freeman A, Johansson C, King S, Morley A, Petersen J, Rawlins P, Spadola L, Thong B, Van de Poël H, Williams N.
    Bioorg Med Chem Lett; 2011 Jan 15; 21(2):777-80. PubMed ID: 21183345
    [Abstract] [Full Text] [Related]

  • 13. Design, synthesis, and evaluation of nonpeptidic inhibitors of human rhinovirus 3C protease.
    Webber SE, Tikhe J, Worland ST, Fuhrman SA, Hendrickson TF, Matthews DA, Love RA, Patick AK, Meador JW, Ferre RA, Brown EL, DeLisle DM, Ford CE, Binford SL.
    J Med Chem; 1996 Dec 20; 39(26):5072-82. PubMed ID: 8978838
    [Abstract] [Full Text] [Related]

  • 14. Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. Part 7: structure-activity studies of bicyclic 2-pyridone-containing peptidomimetics.
    Dragovich PS, Prins TJ, Zhou R, Johnson TO, Brown EL, Maldonado FC, Fuhrman SA, Zalman LS, Patick AK, Matthews DA, Hou X, Meador JW, Ferre RA, Worland ST.
    Bioorg Med Chem Lett; 2002 Mar 11; 12(5):733-8. PubMed ID: 11858991
    [Abstract] [Full Text] [Related]

  • 15. Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
    Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST.
    Proc Natl Acad Sci U S A; 1999 Sep 28; 96(20):11000-7. PubMed ID: 10500114
    [Abstract] [Full Text] [Related]

  • 16. Structure-based design and synthesis of macrocyclic human rhinovirus 3C protease inhibitors.
    Namoto K, Sirockin F, Sellner H, Wiesmann C, Villard F, Moreau RJ, Valeur E, Paulding SC, Schleeger S, Schipp K, Loup J, Andrews L, Swale R, Robinson M, Farady CJ.
    Bioorg Med Chem Lett; 2018 Mar 01; 28(5):906-909. PubMed ID: 29433930
    [Abstract] [Full Text] [Related]

  • 17.
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  • 18. Substituted benzamide inhibitors of human rhinovirus 3C protease: structure-based design, synthesis, and biological evaluation.
    Reich SH, Johnson T, Wallace MB, Kephart SE, Fuhrman SA, Worland ST, Matthews DA, Hendrickson TF, Chan F, Meador J, Ferre RA, Brown EL, DeLisle DM, Patick AK, Binford SL, Ford CE.
    J Med Chem; 2000 May 04; 43(9):1670-83. PubMed ID: 10794684
    [Abstract] [Full Text] [Related]

  • 19. Inhibition of 3C protease from human rhinovirus strain 1B by peptidyl bromomethylketonehydrazides.
    Kati WM, Sham HL, McCall JO, Montgomery DA, Wang GT, Rosenbrook W, Miesbauer L, Buko A, Norbeck DW.
    Arch Biochem Biophys; 1999 Feb 15; 362(2):363-75. PubMed ID: 9989947
    [Abstract] [Full Text] [Related]

  • 20. Structures of Enterovirus 71 3C proteinase (strain E2004104-TW-CDC) and its complex with rupintrivir.
    Wu C, Cai Q, Chen C, Li N, Peng X, Cai Y, Yin K, Chen X, Wang X, Zhang R, Liu L, Chen S, Li J, Lin T.
    Acta Crystallogr D Biol Crystallogr; 2013 May 15; 69(Pt 5):866-71. PubMed ID: 23633597
    [Abstract] [Full Text] [Related]

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