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283 related items for PubMed ID: 10323594

  • 1. Functional comparison of muscarinic partial agonists at muscarinic receptor subtypes hM1, hM2, hM3, hM4 and hM5 using microphysiometry.
    Wood MD, Murkitt KL, Ho M, Watson JM, Brown F, Hunter AJ, Middlemiss DN.
    Br J Pharmacol; 1999 Apr; 126(7):1620-4. PubMed ID: 10323594
    [Abstract] [Full Text] [Related]

  • 2. Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors.
    Watson J, Brough S, Coldwell MC, Gager T, Ho M, Hunter AJ, Jerman J, Middlemiss DN, Riley GJ, Brown AM.
    Br J Pharmacol; 1998 Dec; 125(7):1413-20. PubMed ID: 9884068
    [Abstract] [Full Text] [Related]

  • 3. 6beta-Acetoxynortropane: a potent muscarinic agonist with apparent selectivity toward M2-receptors.
    Pei XF, Gupta TH, Badio B, Padgett WL, Daly JW.
    J Med Chem; 1998 Jun 04; 41(12):2047-55. PubMed ID: 9622546
    [Abstract] [Full Text] [Related]

  • 4. Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives.
    Dei S, Angeli P, Bellucci C, Buccioni M, Gualtieri F, Marucci G, Manetti D, Matucci R, Romanelli MN, Scapecchi S, Teodori E.
    Biochem Pharmacol; 2005 Jun 01; 69(11):1637-45. PubMed ID: 15896343
    [Abstract] [Full Text] [Related]

  • 5. SB 202026: a novel muscarinic partial agonist with functional selectivity for M1 receptors.
    Loudon JM, Bromidge SM, Brown F, Clark MS, Hatcher JP, Hawkins J, Riley GJ, Noy G, Orlek BS.
    J Pharmacol Exp Ther; 1997 Dec 01; 283(3):1059-68. PubMed ID: 9399977
    [Abstract] [Full Text] [Related]

  • 6. Synthesis and biological characterization of 1,4,5,6-tetrahydropyrimidine and 2-amino-3,4,5,6-tetrahydropyridine derivatives as selective m1 agonists.
    Messer WS, Abuh YF, Liu Y, Periyasamy S, Ngur DO, Edgar MA, El-Assadi AA, Sbeih S, Dunbar PG, Roknich S, Rho T, Fang Z, Ojo B, Zhang H, Huzl JJ, Nagy PI.
    J Med Chem; 1997 Apr 11; 40(8):1230-46. PubMed ID: 9111297
    [Abstract] [Full Text] [Related]

  • 7. Pharmacological characterization of human m1 muscarinic acetylcholine receptors with double mutations at the junction of TM VI and the third extracellular domain.
    Huang XP, Williams FE, Peseckis SM, Messer WS.
    J Pharmacol Exp Ther; 1998 Sep 11; 286(3):1129-39. PubMed ID: 9732369
    [Abstract] [Full Text] [Related]

  • 8. Functional properties of muscarinic receptor subtypes Hm1, Hm3 and Hm5 expressed in Sf9 cells using the baculovirus expression system.
    Kukkonen JP, Näsman J, Ojala P, Oker-Blom C, Akerman KE.
    J Pharmacol Exp Ther; 1996 Nov 11; 279(2):593-601. PubMed ID: 8930161
    [Abstract] [Full Text] [Related]

  • 9. Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline.
    Stengel PW, Cohen ML.
    J Pharmacol Exp Ther; 2001 Mar 11; 296(3):818-24. PubMed ID: 11181912
    [Abstract] [Full Text] [Related]

  • 10. Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors.
    Jakubík J, El-Fakahany EE, Dolezal V.
    Mol Pharmacol; 2006 Aug 11; 70(2):656-66. PubMed ID: 16675658
    [Abstract] [Full Text] [Related]

  • 11. Subtype selectivity of the positive allosteric action of alcuronium at cloned M1-M5 muscarinic acetylcholine receptors.
    Jakubík J, Bacáková L, el-Fakahany EE, Tucek S.
    J Pharmacol Exp Ther; 1995 Sep 11; 274(3):1077-83. PubMed ID: 7562472
    [Abstract] [Full Text] [Related]

  • 12. Selectivity profile of muscarinic toxin 3 in functional assays of cloned and native receptors.
    Olianas MC, Ingianni A, Maullu C, Adem A, Karlsson E, Onali P.
    J Pharmacol Exp Ther; 1999 Jan 11; 288(1):164-70. PubMed ID: 9862767
    [Abstract] [Full Text] [Related]

  • 13. Long-term activation upon brief exposure to xanomleline is unique to M1 and M4 subtypes of muscarinic acetylcholine receptors.
    Šantrůčková E, Doležal V, El-Fakahany EE, Jakubík J.
    PLoS One; 2014 Jan 11; 9(2):e88910. PubMed ID: 24558448
    [Abstract] [Full Text] [Related]

  • 14. Persistent binding and functional antagonism by xanomeline at the muscarinic M5 receptor.
    Grant MK, El-Fakahany EE.
    J Pharmacol Exp Ther; 2005 Oct 11; 315(1):313-9. PubMed ID: 16002459
    [Abstract] [Full Text] [Related]

  • 15. Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.
    Scapecchi S, Matucci R, Bellucci C, Buccioni M, Dei S, Guandalini L, Martelli C, Manetti D, Martini E, Marucci G, Nesi M, Romanelli MN, Teodori E, Gualtieri F.
    J Med Chem; 2006 Mar 23; 49(6):1925-31. PubMed ID: 16539379
    [Abstract] [Full Text] [Related]

  • 16. In vitro characterisation of the muscarinic receptor partial agonist, sabcomeline, in rat cortical and heart membranes.
    Watson JM, Hunter AJ, Brown AM, Middlemiss DN.
    Eur J Pharmacol; 1999 Apr 01; 370(1):69-77. PubMed ID: 10323282
    [Abstract] [Full Text] [Related]

  • 17. Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity.
    Lazareno S, Dolezal V, Popham A, Birdsall NJ.
    Mol Pharmacol; 2004 Jan 01; 65(1):257-66. PubMed ID: 14722259
    [Abstract] [Full Text] [Related]

  • 18. Pharmacological comparison of muscarinic ligands: historical versus more recent muscarinic M1-preferring receptor agonists.
    Heinrich JN, Butera JA, Carrick T, Kramer A, Kowal D, Lock T, Marquis KL, Pausch MH, Popiolek M, Sun SC, Tseng E, Uveges AJ, Mayer SC.
    Eur J Pharmacol; 2009 Mar 01; 605(1-3):53-6. PubMed ID: 19168056
    [Abstract] [Full Text] [Related]

  • 19. Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor.
    Christopoulos A, Parsons AM, El-Fakahany EE.
    J Pharmacol Exp Ther; 1999 Jun 01; 289(3):1220-8. PubMed ID: 10336509
    [Abstract] [Full Text] [Related]

  • 20. Subtype-selective positive cooperative interactions between brucine analogs and acetylcholine at muscarinic receptors: functional studies.
    Birdsall NJ, Farries T, Gharagozloo P, Kobayashi S, Lazareno S, Sugimoto M.
    Mol Pharmacol; 1999 Apr 01; 55(4):778-86. PubMed ID: 10101037
    [Abstract] [Full Text] [Related]

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