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Journal Abstract Search

307 related items for PubMed ID: 10330150

  • 1. Rapamycin antifungal action is mediated via conserved complexes with FKBP12 and TOR kinase homologs in Cryptococcus neoformans.
    Cruz MC, Cavallo LM, Görlach JM, Cox G, Perfect JR, Cardenas ME, Heitman J.
    Mol Cell Biol; 1999 Jun; 19(6):4101-12. PubMed ID: 10330150
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  • 2. Rapamycin and less immunosuppressive analogs are toxic to Candida albicans and Cryptococcus neoformans via FKBP12-dependent inhibition of TOR.
    Cruz MC, Goldstein AL, Blankenship J, Del Poeta M, Perfect JR, McCusker JH, Bennani YL, Cardenas ME, Heitman J.
    Antimicrob Agents Chemother; 2001 Nov; 45(11):3162-70. PubMed ID: 11600372
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  • 3. Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor.
    Bastidas RJ, Shertz CA, Lee SC, Heitman J, Cardenas ME.
    Eukaryot Cell; 2012 Mar; 11(3):270-81. PubMed ID: 22210828
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  • 4. Secretion of FK506/FK520 and rapamycin by Streptomyces inhibits the growth of competing Saccharomyces cerevisiae and Cryptococcus neoformans.
    Arndt C, Cruz MC, Cardenas ME, Heitman J.
    Microbiology (Reading); 1999 Aug; 145 ( Pt 8)():1989-2000. PubMed ID: 10463165
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  • 5. TOR mutations confer rapamycin resistance by preventing interaction with FKBP12-rapamycin.
    Lorenz MC, Heitman J.
    J Biol Chem; 1995 Nov 17; 270(46):27531-7. PubMed ID: 7499212
    [Abstract] [Full Text] [Related]

  • 6. Calcineurin is required for virulence of Cryptococcus neoformans.
    Odom A, Muir S, Lim E, Toffaletti DL, Perfect J, Heitman J.
    EMBO J; 1997 May 15; 16(10):2576-89. PubMed ID: 9184205
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  • 9. The immunosuppressant FK506 and its nonimmunosuppressive analog L-685,818 are toxic to Cryptococcus neoformans by inhibition of a common target protein.
    Odom A, Del Poeta M, Perfect J, Heitman J.
    Antimicrob Agents Chemother; 1997 Jan 15; 41(1):156-61. PubMed ID: 8980772
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  • 10. Synergistic antifungal activities of bafilomycin A(1), fluconazole, and the pneumocandin MK-0991/caspofungin acetate (L-743,873) with calcineurin inhibitors FK506 and L-685,818 against Cryptococcus neoformans.
    Del Poeta M, Cruz MC, Cardenas ME, Perfect JR, Heitman J.
    Antimicrob Agents Chemother; 2000 Mar 15; 44(3):739-46. PubMed ID: 10681348
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  • 12. TOR kinase homologs function in a signal transduction pathway that is conserved from yeast to mammals.
    Cutler NS, Heitman J, Cardenas ME.
    Mol Cell Endocrinol; 1999 Sep 10; 155(1-2):135-42. PubMed ID: 10580846
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  • 13. Dominant missense mutations in a novel yeast protein related to mammalian phosphatidylinositol 3-kinase and VPS34 abrogate rapamycin cytotoxicity.
    Cafferkey R, Young PR, McLaughlin MM, Bergsma DJ, Koltin Y, Sathe GM, Faucette L, Eng WK, Johnson RK, Livi GP.
    Mol Cell Biol; 1993 Oct 10; 13(10):6012-23. PubMed ID: 8413204
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  • 14. Mammalian RAFT1 kinase domain provides rapamycin-sensitive TOR function in yeast.
    Alarcon CM, Cardenas ME, Heitman J.
    Genes Dev; 1996 Feb 01; 10(3):279-88. PubMed ID: 8595879
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  • 15. Molecular characterization of a plant FKBP12 that does not mediate action of FK506 and rapamycin.
    Xu Q, Liang S, Kudla J, Luan S.
    Plant J; 1998 Aug 01; 15(4):511-9. PubMed ID: 9753776
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  • 17. RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs.
    Sabatini DM, Erdjument-Bromage H, Lui M, Tempst P, Snyder SH.
    Cell; 1994 Jul 15; 78(1):35-43. PubMed ID: 7518356
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  • 18. Hmo1p, a high mobility group 1/2 homolog, genetically and physically interacts with the yeast FKBP12 prolyl isomerase.
    Dolinski KJ, Heitman J.
    Genetics; 1999 Mar 15; 151(3):935-44. PubMed ID: 10049913
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  • 19. FAP1, a homologue of human transcription factor NF-X1, competes with rapamycin for binding to FKBP12 in yeast.
    Kunz J, Loeschmann A, Deuter-Reinhard M, Hall MN.
    Mol Microbiol; 2000 Sep 15; 37(6):1480-93. PubMed ID: 10998178
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  • 20. Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus.
    Hoy MJ, Park E, Lee H, Lim WY, Cole DC, DeBouver ND, Bobay BG, Pierce PG, Fox D, Ciofani M, Juvvadi PR, Steinbach W, Hong J, Heitman J.
    mBio; 2022 Jun 28; 13(3):e0104922. PubMed ID: 35604094
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