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Journal Abstract Search

341 related items for PubMed ID: 10336509

  • 1. Pharmacological analysis of the novel mode of interaction between xanomeline and the M1 muscarinic acetylcholine receptor.
    Christopoulos A, Parsons AM, El-Fakahany EE.
    J Pharmacol Exp Ther; 1999 Jun; 289(3):1220-8. PubMed ID: 10336509
    [Abstract] [Full Text] [Related]

  • 2. On the unique binding and activating properties of xanomeline at the M1 muscarinic acetylcholine receptor.
    Christopoulos A, Pierce TL, Sorman JL, El-Fakahany EE.
    Mol Pharmacol; 1998 Jun; 53(6):1120-30. PubMed ID: 9614217
    [Abstract] [Full Text] [Related]

  • 3. Long-term changes in the muscarinic M1 receptor induced by instantaneous formation of wash-resistant xanomeline-receptor complex.
    De Lorme KC, Grant MK, Noetzel MJ, Polson SB, El-Fakahany EE.
    J Pharmacol Exp Ther; 2007 Dec; 323(3):868-76. PubMed ID: 17855477
    [Abstract] [Full Text] [Related]

  • 4. Differences in kinetics of xanomeline binding and selectivity of activation of G proteins at M(1) and M(2) muscarinic acetylcholine receptors.
    Jakubík J, El-Fakahany EE, Dolezal V.
    Mol Pharmacol; 2006 Aug; 70(2):656-66. PubMed ID: 16675658
    [Abstract] [Full Text] [Related]

  • 5. Persistent binding and functional antagonism by xanomeline at the muscarinic M5 receptor.
    Grant MK, El-Fakahany EE.
    J Pharmacol Exp Ther; 2005 Oct; 315(1):313-9. PubMed ID: 16002459
    [Abstract] [Full Text] [Related]

  • 6. Functional effects of the muscarinic receptor agonist, xanomeline, at 5-HT1 and 5-HT2 receptors.
    Watson J, Brough S, Coldwell MC, Gager T, Ho M, Hunter AJ, Jerman J, Middlemiss DN, Riley GJ, Brown AM.
    Br J Pharmacol; 1998 Dec; 125(7):1413-20. PubMed ID: 9884068
    [Abstract] [Full Text] [Related]

  • 7. Long-term wash-resistant effects of brief interaction of xanomeline at the M1 muscarinic receptor.
    De Lorme KC, Sikorski KL, Grant MK, El-Fakahany EE.
    Neurosci Lett; 2006 Dec 13; 410(1):11-4. PubMed ID: 17052840
    [Abstract] [Full Text] [Related]

  • 8. Novel persistent activation of muscarinic M1 receptors by xanomeline.
    Christopoulos A, El-Fakahany EE.
    Eur J Pharmacol; 1997 Sep 03; 334(1):R3-4. PubMed ID: 9346340
    [Abstract] [Full Text] [Related]

  • 9. Low-affinity M(2) receptor binding state mediates mouse atrial bradycardia: comparative effects of carbamylcholine and the M(1) receptor agonists sabcomeline and xanomeline.
    Stengel PW, Cohen ML.
    J Pharmacol Exp Ther; 2001 Mar 03; 296(3):818-24. PubMed ID: 11181912
    [Abstract] [Full Text] [Related]

  • 10. Effects of the M1 agonist xanomeline on processing of human beta-amyloid precursor protein (FAD, Swedish mutant) transfected into Chinese hamster ovary-m1 cells.
    DeLapp N, Wu S, Belagaje R, Johnstone E, Little S, Shannon H, Bymaster F, Calligaro D, Mitch C, Whitesitt C, Ward J, Sheardown M, Fink-Jensen A, Jeppesen L, Thomsen C, Sauerberg P.
    Biochem Biophys Res Commun; 1998 Mar 06; 244(1):156-60. PubMed ID: 9514902
    [Abstract] [Full Text] [Related]

  • 11. The assessment of antagonist potency under conditions of transient response kinetics.
    Christopoulos A, Parsons AM, Lew MJ, El-Fakahany EE.
    Eur J Pharmacol; 1999 Oct 15; 382(3):217-27. PubMed ID: 10556673
    [Abstract] [Full Text] [Related]

  • 12. Wash-resistantly bound xanomeline inhibits acetylcholine release by persistent activation of presynaptic M(2) and M(4) muscarinic receptors in rat brain.
    Machová E, Jakubík J, El-Fakahany EE, Dolezal V.
    J Pharmacol Exp Ther; 2007 Jul 15; 322(1):316-23. PubMed ID: 17446301
    [Abstract] [Full Text] [Related]

  • 13. Role of receptor protein and membrane lipids in xanomeline wash-resistant binding to muscarinic M1 receptors.
    Jakubík J, Tucek S, El-Fakahany EE.
    J Pharmacol Exp Ther; 2004 Jan 15; 308(1):105-10. PubMed ID: 14569060
    [Abstract] [Full Text] [Related]

  • 14. Allosteric modulation by persistent binding of xanomeline of the interaction of competitive ligands with the M1 muscarinic acetylcholine receptor.
    Jakubík J, Tucek S, El-Fakahany EE.
    J Pharmacol Exp Ther; 2002 Jun 15; 301(3):1033-41. PubMed ID: 12023535
    [Abstract] [Full Text] [Related]

  • 15. Investigation of the interaction of a putative allosteric modulator, N-(2,3-diphenyl-1,2,4-thiadiazole-5-(2H)-ylidene) methanamine hydrobromide (SCH-202676), with M1 muscarinic acetylcholine receptors.
    Lanzafame A, Christopoulos A.
    J Pharmacol Exp Ther; 2004 Mar 15; 308(3):830-7. PubMed ID: 14617684
    [Abstract] [Full Text] [Related]

  • 16. Xanomeline: a novel muscarinic receptor agonist with functional selectivity for M1 receptors.
    Shannon HE, Bymaster FP, Calligaro DO, Greenwood B, Mitch CH, Sawyer BD, Ward JS, Wong DT, Olesen PH, Sheardown MJ, Swedberg MD, Suzdak PD, Sauerberg P.
    J Pharmacol Exp Ther; 1994 Apr 15; 269(1):271-81. PubMed ID: 7909557
    [Abstract] [Full Text] [Related]

  • 17. Probing the molecular mechanism of interaction between 4-n-butyl-1-[4-(2-methylphenyl)-4-oxo-1-butyl]-piperidine (AC-42) and the muscarinic M(1) receptor: direct pharmacological evidence that AC-42 is an allosteric agonist.
    Langmead CJ, Fry VA, Forbes IT, Branch CL, Christopoulos A, Wood MD, Herdon HJ.
    Mol Pharmacol; 2006 Jan 15; 69(1):236-46. PubMed ID: 16207821
    [Abstract] [Full Text] [Related]

  • 18. Interaction of neuromuscular blocking drugs with recombinant human m1-m5 muscarinic receptors expressed in Chinese hamster ovary cells.
    Cembala TM, Sherwin JD, Tidmarsh MD, Appadu BL, Lambert DG.
    Br J Pharmacol; 1998 Nov 15; 125(5):1088-94. PubMed ID: 9846649
    [Abstract] [Full Text] [Related]

  • 19. On the involvement of multiple muscarinic receptor subtypes in the activation of phosphoinositide metabolism in rat cerebral cortex.
    Forray C, el-Fakahany EE.
    Mol Pharmacol; 1990 Jun 15; 37(6):893-902. PubMed ID: 2163015
    [Abstract] [Full Text] [Related]

  • 20. Synthesis and evaluation of xanomeline analogs--probing the wash-resistant phenomenon at the M1 muscarinic acetylcholine receptor.
    Kane BE, Grant MK, El-Fakahany EE, Ferguson DM.
    Bioorg Med Chem; 2008 Feb 01; 16(3):1376-92. PubMed ID: 17977730
    [Abstract] [Full Text] [Related]

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