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142 related items for PubMed ID: 10366735

  • 1. OHIO-1 beta-lactamase mutants: the Arg244Ser mutant and resistance to beta-lactams and beta-lactamase inhibitors.
    Lin S, Thomas M, Mark S, Anderson V, Bonomo RA.
    Biochim Biophys Acta; 1999 Jun 15; 1432(1):125-36. PubMed ID: 10366735
    [Abstract] [Full Text] [Related]

  • 2. Kinetic analysis of an inhibitor-resistant variant of the OHIO-1 beta-lactamase, an SHV-family class A enzyme.
    Lin S, Thomas M, Shlaes DM, Rudin SD, Knox JR, Anderson V, Bonomo RA.
    Biochem J; 1998 Jul 15; 333 ( Pt 2)(Pt 2):395-400. PubMed ID: 9735103
    [Abstract] [Full Text] [Related]

  • 3. Overcoming resistance to beta-lactamase inhibitors: comparing sulbactam to novel inhibitors against clavulanate resistant SHV enzymes with substitutions at Ambler position 244.
    Thomson JM, Distler AM, Bonomo RA.
    Biochemistry; 2007 Oct 09; 46(40):11361-8. PubMed ID: 17848099
    [Abstract] [Full Text] [Related]

  • 4. Tazobactam is a potent inactivator of selected inhibitor-resistant class A beta-lactamases.
    Bonomo RA, Rudin SA, Shlaes DM.
    FEMS Microbiol Lett; 1997 Mar 01; 148(1):59-62. PubMed ID: 9066111
    [Abstract] [Full Text] [Related]

  • 5. beta-Lactamase mutations far from the active site influence inhibitor binding.
    Bonomo RA, Dawes CG, Knox JR, Shlaes DM.
    Biochim Biophys Acta; 1995 Feb 22; 1247(1):121-5. PubMed ID: 7873581
    [Abstract] [Full Text] [Related]

  • 6. Understanding resistance to beta-lactams and beta-lactamase inhibitors in the SHV beta-lactamase: lessons from the mutagenesis of SER-130.
    Helfand MS, Bethel CR, Hujer AM, Hujer KM, Anderson VE, Bonomo RA.
    J Biol Chem; 2003 Dec 26; 278(52):52724-9. PubMed ID: 14534312
    [Abstract] [Full Text] [Related]

  • 7. Aspartic acid for asparagine substitution at position 276 reduces susceptibility to mechanism-based inhibitors in SHV-1 and SHV-5 beta-lactamases.
    Giakkoupi P, Tzelepi E, Legakis NJ, Tzouvelekis LS.
    J Antimicrob Chemother; 1999 Jan 26; 43(1):23-9. PubMed ID: 10381097
    [Abstract] [Full Text] [Related]

  • 8. Selection and characterization of beta-lactam-beta-lactamase inactivator-resistant mutants following PCR mutagenesis of the TEM-1 beta-lactamase gene.
    Vakulenko SB, Geryk B, Kotra LP, Mobashery S, Lerner SA.
    Antimicrob Agents Chemother; 1998 Jul 26; 42(7):1542-8. PubMed ID: 9660980
    [Abstract] [Full Text] [Related]

  • 9. Probing active site chemistry in SHV beta-lactamase variants at Ambler position 244. Understanding unique properties of inhibitor resistance.
    Thomson JM, Distler AM, Prati F, Bonomo RA.
    J Biol Chem; 2006 Sep 08; 281(36):26734-44. PubMed ID: 16803899
    [Abstract] [Full Text] [Related]

  • 10. Construction and characterization of an OHIO-1 beta-lactamase bearing Met69Ile and Gly238Ser mutations.
    Bonomo RA, Knox JR, Rudin SD, Shlaes DM.
    Antimicrob Agents Chemother; 1997 Sep 08; 41(9):1940-3. PubMed ID: 9303389
    [Abstract] [Full Text] [Related]

  • 11. Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.
    Papp-Wallace KM, Taracila M, Hornick JM, Hujer AM, Hujer KM, Distler AM, Endimiani A, Bonomo RA.
    Antimicrob Agents Chemother; 2010 Jul 08; 54(7):2867-77. PubMed ID: 20421396
    [Abstract] [Full Text] [Related]

  • 12. The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.
    Drawz SM, Bethel CR, Hujer KM, Hurless KN, Distler AM, Caselli E, Prati F, Bonomo RA.
    Biochemistry; 2009 Jun 02; 48(21):4557-66. PubMed ID: 19351161
    [Abstract] [Full Text] [Related]

  • 13. Mutagenesis of amino acid residues in the SHV-1 beta-lactamase: the premier role of Gly238Ser in penicillin and cephalosporin resistance.
    Hujer AM, Hujer KM, Bonomo RA.
    Biochim Biophys Acta; 2001 May 05; 1547(1):37-50. PubMed ID: 11343789
    [Abstract] [Full Text] [Related]

  • 14. Complementary roles of mutations at positions 69 and 242 in a class A beta-lactamase.
    Bonomo RA, Dawes CG, Knox JR, Shlaes DM.
    Biochim Biophys Acta; 1995 Feb 22; 1247(1):113-20. PubMed ID: 7873579
    [Abstract] [Full Text] [Related]

  • 15. Substitution of Met-69 by Ala or Gly in TEM-1 beta-lactamase confer an increased susceptibility to clavulanic acid and other inhibitors.
    Madec S, Blin C, Krishnamoorthy R, Picard B, Chaibi el B, Fouchereau-Péron M, Labia R.
    FEMS Microbiol Lett; 2002 May 21; 211(1):13-6. PubMed ID: 12052544
    [Abstract] [Full Text] [Related]

  • 16. Variants of β-lactamase KPC-2 that are resistant to inhibition by avibactam.
    Papp-Wallace KM, Winkler ML, Taracila MA, Bonomo RA.
    Antimicrob Agents Chemother; 2015 Jul 21; 59(7):3710-7. PubMed ID: 25666153
    [Abstract] [Full Text] [Related]

  • 17. Elucidating the role of Trp105 in the KPC-2 β-lactamase.
    Papp-Wallace KM, Taracila M, Wallace CJ, Hujer KM, Bethel CR, Hornick JM, Bonomo RA.
    Protein Sci; 2010 Sep 21; 19(9):1714-27. PubMed ID: 20662006
    [Abstract] [Full Text] [Related]

  • 18. Construction and characterization of mutants of the TEM-1 beta-lactamase containing amino acid substitutions associated with both extended-spectrum resistance and resistance to beta-lactamase inhibitors.
    Stapleton PD, Shannon KP, French GL.
    Antimicrob Agents Chemother; 1999 Aug 21; 43(8):1881-7. PubMed ID: 10428907
    [Abstract] [Full Text] [Related]

  • 19. OHIO-1 beta-lactamase mutants: Asp179Gly mutation confers resistance to ceftazidime.
    Bonomo RA, Rudin SD, Shlaes DM.
    FEMS Microbiol Lett; 1997 Jul 15; 152(2):275-8. PubMed ID: 9231421
    [Abstract] [Full Text] [Related]

  • 20. Substitutions at position 105 in SHV family β-lactamases decrease catalytic efficiency and cause inhibitor resistance.
    Li M, Conklin BC, Taracila MA, Hutton RA, Skalweit MJ.
    Antimicrob Agents Chemother; 2012 Nov 15; 56(11):5678-86. PubMed ID: 22908166
    [Abstract] [Full Text] [Related]

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