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309 related items for PubMed ID: 10374879

  • 1. In acute promyelocytic leukemia NB4 cells, the synthetic retinoid CD437 induces contemporaneously apoptosis, a caspase-3-mediated degradation of PML/RARalpha protein and the PML retargeting on PML-nuclear bodies.
    Giannì M, de Thé H.
    Leukemia; 1999 May; 13(5):739-49. PubMed ID: 10374879
    [Abstract] [Full Text] [Related]

  • 2. PIC-1/SUMO-1-modified PML-retinoic acid receptor alpha mediates arsenic trioxide-induced apoptosis in acute promyelocytic leukemia.
    Sternsdorf T, Puccetti E, Jensen K, Hoelzer D, Will H, Ottmann OG, Ruthardt M.
    Mol Cell Biol; 1999 Jul; 19(7):5170-8. PubMed ID: 10373566
    [Abstract] [Full Text] [Related]

  • 3. The novel synthetic retinoid 6-[3-adamantyl-4-hydroxyphenyl]-2-naphthalene carboxylic acid (CD437) causes apoptosis in acute promyelocytic leukemia cells through rapid activation of caspases.
    Mologni L, Ponzanelli I, Bresciani F, Sardiello G, Bergamaschi D, Gianní M, Reichert U, Rambaldi A, Terao M, Garattini E.
    Blood; 1999 Feb 01; 93(3):1045-61. PubMed ID: 9920855
    [Abstract] [Full Text] [Related]

  • 4. Arsenic trioxide and melarsoprol induce programmed cell death in myeloid leukemia cell lines and function in a PML and PML-RARalpha independent manner.
    Wang ZG, Rivi R, Delva L, König A, Scheinberg DA, Gambacorti-Passerini C, Gabrilove JL, Warrell RP, Pandolfi PP.
    Blood; 1998 Sep 01; 92(5):1497-504. PubMed ID: 9716575
    [Abstract] [Full Text] [Related]

  • 5. cAMP signalling is decisive for recovery of nuclear bodies (PODs) during maturation of RA-resistant t(15;17) promyelocytic leukemia NB4 cells expressing PML-RAR alpha.
    Duprez E, Lillehaug JR, Naoe T, Lanotte M.
    Oncogene; 1996 Jun 06; 12(11):2451-9. PubMed ID: 8649787
    [Abstract] [Full Text] [Related]

  • 6. Differential changes of retinoid-X-receptor (RXR alpha) and its RAR alpha and PML-RAR alpha partners induced by retinoic acid and cAMP distinguish maturation sensitive and resistant t(15;17) promyelocytic leukemia NB4 cells.
    Duprez E, Lillehaug JR, Gaub MP, Lanotte M.
    Oncogene; 1996 Jun 06; 12(11):2443-50. PubMed ID: 8649786
    [Abstract] [Full Text] [Related]

  • 7. Caspases mediate retinoic acid-induced degradation of the acute promyelocytic leukemia PML/RARalpha fusion protein.
    Nervi C, Ferrara FF, Fanelli M, Rippo MR, Tomassini B, Ferrucci PF, Ruthardt M, Gelmetti V, Gambacorti-Passerini C, Diverio D, Grignani F, Pelicci PG, Testi R.
    Blood; 1998 Oct 01; 92(7):2244-51. PubMed ID: 9746761
    [Abstract] [Full Text] [Related]

  • 8. In vitro studies on cellular and molecular mechanisms of arsenic trioxide (As2O3) in the treatment of acute promyelocytic leukemia: As2O3 induces NB4 cell apoptosis with downregulation of Bcl-2 expression and modulation of PML-RAR alpha/PML proteins.
    Chen GQ, Zhu J, Shi XG, Ni JH, Zhong HJ, Si GY, Jin XL, Tang W, Li XS, Xong SM, Shen ZX, Sun GL, Ma J, Zhang P, Zhang TD, Gazin C, Naoe T, Chen SJ, Wang ZY, Chen Z.
    Blood; 1996 Aug 01; 88(3):1052-61. PubMed ID: 8704214
    [Abstract] [Full Text] [Related]

  • 9. Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation.
    Wang QQ, Zhou XY, Zhang YF, Bu N, Zhou J, Cao FL, Naranmandura H.
    Oncotarget; 2015 Sep 22; 6(28):25646-59. PubMed ID: 26213848
    [Abstract] [Full Text] [Related]

  • 10. Triterpenoid CDDO-Im downregulates PML/RARalpha expression in acute promyelocytic leukemia cells.
    Ikeda T, Kimura F, Nakata Y, Sato K, Ogura K, Motoyoshi K, Sporn M, Kufe D.
    Cell Death Differ; 2005 May 22; 12(5):523-31. PubMed ID: 15746941
    [Abstract] [Full Text] [Related]

  • 11. Role of promyelocytic leukemia (PML) sumolation in nuclear body formation, 11S proteasome recruitment, and As2O3-induced PML or PML/retinoic acid receptor alpha degradation.
    Lallemand-Breitenbach V, Zhu J, Puvion F, Koken M, Honoré N, Doubeikovsky A, Duprez E, Pandolfi PP, Puvion E, Freemont P, de Thé H.
    J Exp Med; 2001 Jun 18; 193(12):1361-71. PubMed ID: 11413191
    [Abstract] [Full Text] [Related]

  • 12. Involvement of CD95-independent caspase 8 activation in arsenic trioxide-induced apoptosis.
    Kitamura K, Minami Y, Yamamoto K, Akao Y, Kiyoi H, Saito H, Naoe T.
    Leukemia; 2000 Oct 18; 14(10):1743-50. PubMed ID: 11021749
    [Abstract] [Full Text] [Related]

  • 13. RXRα ligand Z-10 induces PML-RARα cleavage and APL cell apoptosis through disrupting PML-RARα/RXRα complex in a cAMP-independent manner.
    Xu L, Zeng Z, Zhang W, Ren G, Ling X, Huang F, Xie P, Su Y, Zhang XK, Zhou H.
    Oncotarget; 2017 Feb 14; 8(7):12311-12322. PubMed ID: 28129653
    [Abstract] [Full Text] [Related]

  • 14. Novel treatment of acute promyelocytic leukemia: As₂O₃, retinoic acid and retinoid pharmacology.
    Zhu G.
    Curr Pharm Biotechnol; 2013 Feb 14; 14(9):849-58. PubMed ID: 24433507
    [Abstract] [Full Text] [Related]

  • 15. [Effects of arsenic trioxide on the subcellular localization of PML/PML-RARalpha protein in leukemic cells].
    Ni J, Chen G, Zhu J, Zhong H, Tang W, Li X, Xiong S, Shen Z, Chen S, Wang Z, Chen L.
    Zhonghua Xue Ye Xue Za Zhi; 1997 Jan 14; 18(1):32-4. PubMed ID: 15622748
    [Abstract] [Full Text] [Related]

  • 16. Therapeutic targeting of nuclear receptor corepressor misfolding in acute promyelocytic leukemia cells with genistein.
    Ng AP, Nin DS, Fong JH, Venkataraman D, Chen CS, Khan M.
    Mol Cancer Ther; 2007 Aug 14; 6(8):2240-8. PubMed ID: 17699721
    [Abstract] [Full Text] [Related]

  • 17. Combined arsenic and retinoic acid treatment enhances differentiation and apoptosis in arsenic-resistant NB4 cells.
    Giannì M, Koken MH, Chelbi-Alix MK, Benoit G, Lanotte M, Chen Z, de Thé H.
    Blood; 1998 Jun 01; 91(11):4300-10. PubMed ID: 9596679
    [Abstract] [Full Text] [Related]

  • 18. The PML/RARalpha fusion protein inhibits tumor necrosis factor-alpha-induced apoptosis in U937 cells and acute promyelocytic leukemia blasts.
    Testa U, Grignani F, Samoggia P, Zanetti C, Riccioni R, Lo Coco F, Diverio D, Felli N, Passerini CG, Grell M, Pelicci PG, Peschle C.
    J Clin Invest; 1998 May 15; 101(10):2278-89. PubMed ID: 9593784
    [Abstract] [Full Text] [Related]

  • 19. Retinoid-induced differentiation of acute promyelocytic leukemia involves PML-RARalpha-mediated increase of type II transglutaminase.
    Benedetti L, Grignani F, Scicchitano BM, Jetten AM, Diverio D, Lo Coco F, Avvisati G, Gambacorti-Passerini C, Adamo S, Levin AA, Pelicci PG, Nervi C.
    Blood; 1996 Mar 01; 87(5):1939-50. PubMed ID: 8634442
    [Abstract] [Full Text] [Related]

  • 20. Retinoic acid, but not arsenic trioxide, degrades the PLZF/RARalpha fusion protein, without inducing terminal differentiation or apoptosis, in a RA-therapy resistant t(11;17)(q23;q21) APL patient.
    Koken MH, Daniel MT, Gianni M, Zelent A, Licht J, Buzyn A, Minard P, Degos L, Varet B, de Thé H.
    Oncogene; 1999 Jan 28; 18(4):1113-8. PubMed ID: 10023688
    [Abstract] [Full Text] [Related]

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