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Journal Abstract Search

152 related items for PubMed ID: 10423173

  • 1. N6-cyclopropyl-PMEDAP: a novel derivative of 9-(2-phosphonylmethoxyethyl)-2,6-diaminopurine (PMEDAP) with distinct metabolic, antiproliferative, and differentiation-inducing properties.
    Hatse S, Naesens L, De Clercq E, Balzarini J.
    Biochem Pharmacol; 1999 Jul 15; 58(2):311-23. PubMed ID: 10423173
    [Abstract] [Full Text] [Related]

  • 2. 9-(2-Phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine (cpr-PMEDAP) as a prodrug of 9-(2-phosphonylmethoxyethyl)guanine (PMEG).
    Compton ML, Toole JJ, Paborsky LR.
    Biochem Pharmacol; 1999 Aug 15; 58(4):709-14. PubMed ID: 10413310
    [Abstract] [Full Text] [Related]

  • 3. 9-(2-phosphonylmethoxyethyl)-N6-cyclopropyl-2,6-diaminopurine: a novel prodrug of 9-(2-phosphonylmethoxyethyl)guanine with improved antitumor efficacy and selectivity in choriocarcinoma-bearing rats.
    Naesens L, Hatse S, Segers C, Verbeken E, De Clercq E, Waer M, Balzarini J.
    Oncol Res; 1999 Aug 15; 11(4):195-203. PubMed ID: 10566618
    [Abstract] [Full Text] [Related]

  • 4. Selection and characterisation of murine leukaemia L1210 cells with high-level resistance to the cytostatic activity of the acyclic nucleoside phosphonate 9-(2-phosphonylmethoxyethyl) adenine (PMEA).
    Balzarini J, Hatse S, Naesens L, De Clercq E.
    Biochim Biophys Acta; 1998 Mar 12; 1402(1):29-38. PubMed ID: 9551083
    [Abstract] [Full Text] [Related]

  • 5. 9-(2-phosphonylmethoxyethyl) derivatives of purine nucleotide analogs: A comparison of their metabolism and interaction with cellular DNA synthesis.
    Kramata P, Downey KM.
    Mol Pharmacol; 1999 Dec 12; 56(6):1262-70. PubMed ID: 10570054
    [Abstract] [Full Text] [Related]

  • 6. Antitumour activity of N6-substituted PMEDAP derivatives against T-cell lymphoma.
    Valeriánová M, Votruba I, Holy A, Mandys V, Otová B.
    Anticancer Res; 2001 Dec 12; 21(3B):2057-64. PubMed ID: 11497298
    [Abstract] [Full Text] [Related]

  • 7. Evidence for distinction of the differentiation-inducing activities and cytostatic properties of 9-(2-phosphonylmethoxyethyl)adenine and a variety of differentiation-inducing agents in human erythroleukemia K562 cells.
    Hatse S, De Clercq E, Balzarini J.
    Mol Pharmacol; 1996 Nov 12; 50(5):1231-42. PubMed ID: 8913355
    [Abstract] [Full Text] [Related]

  • 8. Mutations in adenosine deaminase-like (ADAL) protein confer resistance to the antiproliferative agents N6-cyclopropyl-PMEDAP and GS-9219.
    Frey CR, Andrei G, Votruba I, Cannizzaro C, Han B, Fung W, Hung M, Liu X, Geleziunas R, Fiten P, Opdenakker G, Snoeck R, Cihlar T.
    Anticancer Res; 2013 May 12; 33(5):1899-912. PubMed ID: 23645737
    [Abstract] [Full Text] [Related]

  • 9. Acyclic nucleotide analogues suppress growth and induce apoptosis in human leukemia cell lines.
    Franek F, Holy A, Votruba I, Eckschlager T.
    Int J Oncol; 1999 Apr 12; 14(4):745-52. PubMed ID: 10087324
    [Abstract] [Full Text] [Related]

  • 10. Distinct modulation of telomere length in two T-lymphoblastic leukemia cell lines by cytotoxic nucleoside phosphonates PMEG and PMEDAP.
    Hájek M, Cvilink V, Votruba I, Holý A, Mertlíková-Kaiserová H.
    Eur J Pharmacol; 2010 Sep 15; 643(1):6-12. PubMed ID: 20599933
    [Abstract] [Full Text] [Related]

  • 11. Point mutations in human guanylate kinase account for acquired resistance to anticancer nucleotide analogue PMEG.
    Mertlíková-Kaiserová H, Rumlová M, Tloušťová E, Procházková E, Holý A, Votruba I.
    Biochem Pharmacol; 2011 Jul 15; 82(2):131-8. PubMed ID: 21515241
    [Abstract] [Full Text] [Related]

  • 12. Antiproliferative effects of acyclic nucleoside phosphonates on human papillomavirus (HPV)-harboring cell lines compared with HPV-negative cell lines.
    Andrei G, Snoeck R, Piette J, Delvenne P, De Clercq E.
    Oncol Res; 1998 Jul 15; 10(10):523-31. PubMed ID: 10338155
    [Abstract] [Full Text] [Related]

  • 13. Enhanced topical and transdermal delivery of antineoplastic and antiviral acyclic nucleoside phosphonate cPr-PMEDAP.
    Vávrová K, Kovaříková P, Skolová B, Líbalová M, Roh J, Cáp R, Holý A, Hrabálek A.
    Pharm Res; 2011 Dec 15; 28(12):3105-15. PubMed ID: 21671133
    [Abstract] [Full Text] [Related]

  • 14. Impact of 9-(2-phosphonylmethoxyethyl)adenine on (deoxy)ribonucleotide metabolism and nucleic acid synthesis in tumor cells.
    Hatse S, De Clercq E, Balzarini J.
    FEBS Lett; 1999 Feb 19; 445(1):92-7. PubMed ID: 10069380
    [Abstract] [Full Text] [Related]

  • 15. Intracellular metabolism and action of acyclic nucleoside phosphonates on DNA replication.
    Pisarev VM, Lee SH, Connelly MC, Fridland A.
    Mol Pharmacol; 1997 Jul 19; 52(1):63-8. PubMed ID: 9224813
    [Abstract] [Full Text] [Related]

  • 16. The human immunodeficiency virus(HIV) inhibitor 9-(2-phosphonylmethoxyethyl)adenine (PMEA) is a strong inducer of differentiation of several tumor cell lines.
    Balzarini J, Verstuyf A, Hatse S, Goebels J, Sobis H, Vandeputte M, De Clercq E.
    Int J Cancer; 1995 Mar 29; 61(1):130-7. PubMed ID: 7705926
    [Abstract] [Full Text] [Related]

  • 17. GS-9191 is a novel topical prodrug of the nucleotide analog 9-(2-phosphonylmethoxyethyl)guanine with antiproliferative activity and possible utility in the treatment of human papillomavirus lesions.
    Wolfgang GH, Shibata R, Wang J, Ray AS, Wu S, Doerrfler E, Reiser H, Lee WA, Birkus G, Christensen ND, Andrei G, Snoeck R.
    Antimicrob Agents Chemother; 2009 Jul 29; 53(7):2777-84. PubMed ID: 19398642
    [Abstract] [Full Text] [Related]

  • 18. Involvement of MAP kinases in the cytotoxicity of acyclic nucleoside phosphonates.
    Mertlíková-Kaiserová H, Nejedlá M, Holy A, Votruba I.
    Anticancer Res; 2012 Feb 29; 32(2):497-501. PubMed ID: 22287737
    [Abstract] [Full Text] [Related]

  • 19. Interaction of guanine phosphonomethoxyalkyl derivatives with GMP kinase isoenzymes.
    Krejcová R, Horská K, Votruba I, Holý A.
    Biochem Pharmacol; 2000 Dec 15; 60(12):1907-13. PubMed ID: 11108807
    [Abstract] [Full Text] [Related]

  • 20. 9-(2-Phosphonylmethoxyethyl)adenine induces tumor cell differentiation or cell death by blocking cell cycle progression through the S phase.
    Hatse S, Schols D, De Clercq E, Balzarini J.
    Cell Growth Differ; 1999 Jun 15; 10(6):435-46. PubMed ID: 10392905
    [Abstract] [Full Text] [Related]

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