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627 related items for PubMed ID: 10432311

  • 1. Methotrexate inhibits the first committed step of purine biosynthesis in mitogen-stimulated human T-lymphocytes: a metabolic basis for efficacy in rheumatoid arthritis?
    Fairbanks LD, Rückemann K, Qiu Y, Hawrylowicz CM, Richards DF, Swaminathan R, Kirschbaum B, Simmonds HA.
    Biochem J; 1999 Aug 15; 342 ( Pt 1)(Pt 1):143-52. PubMed ID: 10432311
    [Abstract] [Full Text] [Related]

  • 2. Immunosuppressive properties of methotrexate: apoptosis and clonal deletion of activated peripheral T cells.
    Genestier L, Paillot R, Fournel S, Ferraro C, Miossec P, Revillard JP.
    J Clin Invest; 1998 Jul 15; 102(2):322-8. PubMed ID: 9664073
    [Abstract] [Full Text] [Related]

  • 3. Mycophenolic acid-induced GTP depletion also affects ATP and pyrimidine synthesis in mitogen-stimulated primary human T-lymphocytes.
    Qiu Y, Fairbanks LD, Rückermann K, Hawrlowicz CM, Richards DF, Kirschbaum B, Simmonds HA.
    Transplantation; 2000 Mar 15; 69(5):890-7. PubMed ID: 10755546
    [Abstract] [Full Text] [Related]

  • 4. Suppression of B cell function by methotrexate and trimetrexate. Evidence for inhibition of purine biosynthesis as a major mechanism of action.
    Rosenthal GJ, Weigand GW, Germolec DR, Blank JA, Luster MI.
    J Immunol; 1988 Jul 15; 141(2):410-6. PubMed ID: 2968399
    [Abstract] [Full Text] [Related]

  • 5. Effects of methotrexate on nucleotide pools in normal human T cells and the CEM T cell line.
    Budzik GP, Colletti LM, Faltynek CR.
    Life Sci; 2000 Jul 15; 66(23):2297-307. PubMed ID: 10855951
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis.
    Gerards AH, de Lathouder S, de Groot ER, Dijkmans BA, Aarden LA.
    Rheumatology (Oxford); 2003 Oct 15; 42(10):1189-96. PubMed ID: 12777636
    [Abstract] [Full Text] [Related]

  • 7. Leflunomide inhibits pyrimidine de novo synthesis in mitogen-stimulated T-lymphocytes from healthy humans.
    Rückemann K, Fairbanks LD, Carrey EA, Hawrylowicz CM, Richards DF, Kirschbaum B, Simmonds HA.
    J Biol Chem; 1998 Aug 21; 273(34):21682-91. PubMed ID: 9705303
    [Abstract] [Full Text] [Related]

  • 8. Gout and the regulation of purine biosynthesis.
    Hershfield MS, Seegmiller JE.
    Horiz Biochem Biophys; 1976 Aug 21; 2():134-62. PubMed ID: 776767
    [Abstract] [Full Text] [Related]

  • 9. Purine de novo synthesis as the basis of synergism of methotrexate and 6-mercaptopurine in human malignant lymphoblasts of different lineages.
    Bökkerink JP, Bakker MA, Hulscher TW, De Abreu RA, Schretlen ED.
    Biochem Pharmacol; 1988 Jun 15; 37(12):2321-7. PubMed ID: 2455519
    [Abstract] [Full Text] [Related]

  • 10. Effects of guanine ribonucleotide accumulation on the metabolism and cell cycle of human lymphoid cells.
    Sidi Y, Hudson JL, Mitchell BS.
    Cancer Res; 1985 Oct 15; 45(10):4940-5. PubMed ID: 2411392
    [Abstract] [Full Text] [Related]

  • 11. Ecto-5'-nucleotidase can provide the total purine requirements of mitogen-stimulated human T cells and rapidly dividing human B lymphoblastoid cells.
    Thompson LF.
    J Immunol; 1985 Jun 15; 134(6):3794-7. PubMed ID: 2985697
    [Abstract] [Full Text] [Related]

  • 12. [Use of purine rescue pathways by L1210 cells exposed to methotrexate in vitro].
    Buesa JM.
    Rev Esp Oncol; 1982 Jun 15; 29(4):641-7. PubMed ID: 6085740
    [Abstract] [Full Text] [Related]

  • 13. Sequence-, time- and dose-dependent synergism of methotrexate and 6-mercaptopurine in malignant human T-lymphoblasts.
    Bökkerink JP, Bakker MA, Hulscher TW, De Abreu RR, Schretlen ED, van Laarhoven JP, De Bruyn CH.
    Biochem Pharmacol; 1986 Oct 15; 35(20):3549-55. PubMed ID: 2429667
    [Abstract] [Full Text] [Related]

  • 14. Key role of uridine kinase and uridine phosphorylase in the homeostatic regulation of purine and pyrimidine salvage in brain.
    Balestri F, Barsotti C, Lutzemberger L, Camici M, Ipata PL.
    Neurochem Int; 2007 Dec 15; 51(8):517-23. PubMed ID: 17643556
    [Abstract] [Full Text] [Related]

  • 15. De novo synthesis of purine nucleotides in human peripheral blood leukocytes. Excessive activity of the pathway in hypoxanthine-guanine phosphoribosyltransferase deficiency.
    Brosh S, Boer P, Kupfer B, de Vries A, Sperling O.
    J Clin Invest; 1976 Aug 15; 58(2):289-97. PubMed ID: 956368
    [Abstract] [Full Text] [Related]

  • 16. The anti-inflammatory action of methotrexate is not mediated by lymphocyte apoptosis, but by the suppression of activation and adhesion molecules.
    Johnston A, Gudjonsson JE, Sigmundsdottir H, Ludviksson BR, Valdimarsson H.
    Clin Immunol; 2005 Feb 15; 114(2):154-63. PubMed ID: 15639649
    [Abstract] [Full Text] [Related]

  • 17. The immunosuppressant leflunomide inhibits lymphocyte proliferation by inhibiting pyrimidine biosynthesis.
    Cherwinski HM, Cohn RG, Cheung P, Webster DJ, Xu YZ, Caulfield JP, Young JM, Nakano G, Ransom JT.
    J Pharmacol Exp Ther; 1995 Nov 15; 275(2):1043-9. PubMed ID: 7473131
    [Abstract] [Full Text] [Related]

  • 18. Effects of methotrexate on purine and pyrimidine metabolism and cell-kinetic parameters in human malignant lymphoblasts of different lineages.
    Bökkerink JP, De Abreu RA, Bakker MA, Hulscher TW, van Baal JM, Schretlen ED, De Bruijn CH.
    Biochem Pharmacol; 1988 Jun 15; 37(12):2329-38. PubMed ID: 2455520
    [Abstract] [Full Text] [Related]

  • 19. Biochemical and cell cycle perturbations in methotrexate-treated cells.
    Taylor IW, Slowiaczek P, Francis PR, Tattersall MH.
    Mol Pharmacol; 1982 Jan 15; 21(1):204-10. PubMed ID: 6982394
    [Abstract] [Full Text] [Related]

  • 20. Impact of polyglutamation on sensitivity to raltitrexed and methotrexate in relation to drug-induced inhibition of de novo thymidylate and purine biosynthesis in CCRF-CEM cell lines.
    Barnes MJ, Estlin EJ, Taylor GA, Aherne GW, Hardcastle A, McGuire JJ, Calvete JA, Lunec J, Pearson AD, Newell DR.
    Clin Cancer Res; 1999 Sep 15; 5(9):2548-58. PubMed ID: 10499632
    [Abstract] [Full Text] [Related]

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