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Journal Abstract Search

171 related items for PubMed ID: 10458702

  • 1. 2,2',3,3',6,6'-hexachlorobiphenyl hydroxylation by active site mutants of cytochrome P450 2B1 and 2B11.
    Waller SC, He YA, Harlow GR, He YQ, Mash EA, Halpert JR.
    Chem Res Toxicol; 1999 Aug; 12(8):690-9. PubMed ID: 10458702
    [Abstract] [Full Text] [Related]

  • 2. Escherichia coli expression and characterization of cytochromes P450 2B11, 2B1, and 2B5.
    John GH, Hasler JA, He YA, Halpert JR.
    Arch Biochem Biophys; 1994 Nov 01; 314(2):367-75. PubMed ID: 7979377
    [Abstract] [Full Text] [Related]

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  • 4. Site-directed mutagenesis of putative substrate recognition sites in cytochrome P450 2B11: importance of amino acid residues 114, 290, and 363 for substrate specificity.
    Hasler JA, Harlow GR, Szklarz GD, John GH, Kedzie KM, Burnett VL, He YA, Kaminsky LS, Halpert JR.
    Mol Pharmacol; 1994 Aug 01; 46(2):338-45. PubMed ID: 8078495
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  • 6. Probing the active site of cytochrome P450 2B1: metabolism of 7-alkoxycoumarins by the wild type and five site-directed mutants.
    Kobayashi Y, Fang X, Szklarz GD, Halpert JR.
    Biochemistry; 1998 May 12; 37(19):6679-88. PubMed ID: 9578551
    [Abstract] [Full Text] [Related]

  • 7. Mutagenesis study of Asp-290 in cytochrome P450 2B11 using a fusion protein with rat NADPH-cytochrome P450 reductase.
    Harlow GR, Halpert JR.
    Arch Biochem Biophys; 1996 Feb 01; 326(1):85-92. PubMed ID: 8579377
    [Abstract] [Full Text] [Related]

  • 8. Role of the alanine at position 363 of cytochrome P450 2B2 in influencing the NADPH- and hydroperoxide-supported activities.
    Hanna IH, Teiber JF, Kokones KL, Hollenberg PF.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):324-32. PubMed ID: 9473308
    [Abstract] [Full Text] [Related]

  • 9. Stoichiometry of 7-ethoxycoumarin metabolism by cytochrome P450 2B1 wild-type and five active-site mutants.
    Fang X, Kobayashi Y, Halpert JR.
    FEBS Lett; 1997 Oct 13; 416(1):77-80. PubMed ID: 9369237
    [Abstract] [Full Text] [Related]

  • 10. Characterization of the progesterone 21-hydroxylase activity of canine cytochrome P450 PBD-2/P450 2B11 through reconstitution, heterologous expression, and site-directed mutagenesis.
    Born SL, John GH, Harlow GR, Halpert JR.
    Drug Metab Dispos; 1995 Jul 13; 23(7):702-7. PubMed ID: 7587957
    [Abstract] [Full Text] [Related]

  • 11. Molecular basis for the differences in lidocaine binding and regioselectivity of oxidation by cytochromes P450 2B1 and 2B2.
    Hanna IH, Roberts ES, Hollenberg PF.
    Biochemistry; 1998 Jan 06; 37(1):311-8. PubMed ID: 9425052
    [Abstract] [Full Text] [Related]

  • 12. Functional interaction between amino-acid residues 242 and 290 in cytochromes P-450 2B1 and 2B11.
    Harlow GR, He YA, Halpert JR.
    Biochim Biophys Acta; 1997 Apr 04; 1338(2):259-66. PubMed ID: 9128144
    [Abstract] [Full Text] [Related]

  • 13. Role of residues 363 and 206 in conversion of cytochrome P450 2B1 from a steroid 16-hydroxylase to a 15 alpha-hydroxylase.
    Luo Z, He YA, Halpert JR.
    Arch Biochem Biophys; 1994 Feb 15; 309(1):52-7. PubMed ID: 8117113
    [Abstract] [Full Text] [Related]

  • 14. Threonine-205 in the F helix of p450 2B1 contributes to androgen 16 beta-hydroxylation activity and mechanism-based inactivation.
    Lin HL, Zhang H, Waskell L, Hollenberg PF.
    J Pharmacol Exp Ther; 2003 Aug 15; 306(2):744-51. PubMed ID: 12721329
    [Abstract] [Full Text] [Related]

  • 15. Structural determinants of progesterone hydroxylation by cytochrome P450 2B5: the role of nonsubstrate recognition site residues.
    He YQ, Harlow GR, Szklarz GD, Halpert JR.
    Arch Biochem Biophys; 1998 Feb 15; 350(2):333-9. PubMed ID: 9473309
    [Abstract] [Full Text] [Related]

  • 16. Directed evolution of mammalian cytochrome P450 2B1: mutations outside of the active site enhance the metabolism of several substrates, including the anticancer prodrugs cyclophosphamide and ifosfamide.
    Kumar S, Chen CS, Waxman DJ, Halpert JR.
    J Biol Chem; 2005 May 20; 280(20):19569-75. PubMed ID: 15774478
    [Abstract] [Full Text] [Related]

  • 17. Escherichia coli expression of site-directed mutants of cytochrome P450 2B1 from six substrate recognition sites: substrate specificity and inhibitor selectivity studies.
    He YQ, He YA, Halpert JR.
    Chem Res Toxicol; 1995 Jun 20; 8(4):574-9. PubMed ID: 7548737
    [Abstract] [Full Text] [Related]

  • 18. Site-directed mutagenesis as a tool for molecular modeling of cytochrome P450 2B1.
    Szklarz GD, He YA, Halpert JR.
    Biochemistry; 1995 Nov 07; 34(44):14312-22. PubMed ID: 7578035
    [Abstract] [Full Text] [Related]

  • 19. A rational approach to Re-engineer cytochrome P450 2B1 regioselectivity based on the crystal structure of cytochrome P450 2C5.
    Kumar S, Scott EE, Liu H, Halpert JR.
    J Biol Chem; 2003 May 09; 278(19):17178-84. PubMed ID: 12609983
    [Abstract] [Full Text] [Related]

  • 20. The role of cytochrome 2B1 substrate recognition site residues 115, 294, 297, 298, and 362 in the oxidation of steroids and 7-alkoxycoumarins.
    Domanski TL, He YQ, Scott EE, Wang Q, Halpert JR.
    Arch Biochem Biophys; 2001 Oct 01; 394(1):21-8. PubMed ID: 11566023
    [Abstract] [Full Text] [Related]

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