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184 related items for PubMed ID: 10460145

  • 1. Phenylalanine residues in the active site of tyrosine hydroxylase: mutagenesis of Phe300 and Phe309 to alanine and metal ion-catalyzed hydroxylation of Phe300.
    Ellis HR, Daubner SC, McCulloch RI, Fitzpatrick PF.
    Biochemistry; 1999 Aug 24; 38(34):10909-14. PubMed ID: 10460145
    [Abstract] [Full Text] [Related]

  • 2. Site-directed mutants of charged residues in the active site of tyrosine hydroxylase.
    Daubner SC, Fitzpatrick PF.
    Biochemistry; 1999 Apr 06; 38(14):4448-54. PubMed ID: 10194366
    [Abstract] [Full Text] [Related]

  • 3. Crystal structure of tyrosine hydroxylase with bound cofactor analogue and iron at 2.3 A resolution: self-hydroxylation of Phe300 and the pterin-binding site.
    Goodwill KE, Sabatier C, Stevens RC.
    Biochemistry; 1998 Sep 29; 37(39):13437-45. PubMed ID: 9753429
    [Abstract] [Full Text] [Related]

  • 4. Mutation to phenylalanine of tyrosine 371 in tyrosine hydroxylase increases the affinity for phenylalanine.
    Daubner SC, Fitzpatrick PF.
    Biochemistry; 1998 Nov 17; 37(46):16440-4. PubMed ID: 9819237
    [Abstract] [Full Text] [Related]

  • 5. Lysine241 of tyrosine hydroxylase is not required for binding of tetrahydrobiopterin substrate.
    Daubner SC, Fitzpatrick PF.
    Arch Biochem Biophys; 1993 May 17; 302(2):455-60. PubMed ID: 8098196
    [Abstract] [Full Text] [Related]

  • 6. Characterization of chimeric pterin-dependent hydroxylases: contributions of the regulatory domains of tyrosine and phenylalanine hydroxylase to substrate specificity.
    Daubner SC, Hillas PJ, Fitzpatrick PF.
    Biochemistry; 1997 Sep 30; 36(39):11574-82. PubMed ID: 9305947
    [Abstract] [Full Text] [Related]

  • 7. Characterization of metal ligand mutants of tyrosine hydroxylase: insights into the plasticity of a 2-histidine-1-carboxylate triad.
    Fitzpatrick PF, Ralph EC, Ellis HR, Willmon OJ, Daubner SC.
    Biochemistry; 2003 Feb 25; 42(7):2081-8. PubMed ID: 12590596
    [Abstract] [Full Text] [Related]

  • 8. Expression and characterization of the catalytic domain of human phenylalanine hydroxylase.
    Daubner SC, Hillas PJ, Fitzpatrick PF.
    Arch Biochem Biophys; 1997 Dec 15; 348(2):295-302. PubMed ID: 9434741
    [Abstract] [Full Text] [Related]

  • 9. The active site residue tyrosine 325 influences iron binding and coupling efficiency in human phenylalanine hydroxylase.
    Miranda FF, Kolberg M, Andersson KK, Geraldes CF, Martínez A.
    J Inorg Biochem; 2005 Jun 15; 99(6):1320-8. PubMed ID: 15917086
    [Abstract] [Full Text] [Related]

  • 10. Posttranslational hydroxylation of human phenylalanine hydroxylase is a novel example of enzyme self-repair within the second coordination sphere of catalytic iron.
    Kinzie SD, Thevis M, Ngo K, Whitelegge J, Loo JA, Abu-Omar MM.
    J Am Chem Soc; 2003 Apr 23; 125(16):4710-1. PubMed ID: 12696880
    [Abstract] [Full Text] [Related]

  • 11. Alanine scanning mutagenesis of the testosterone binding site of rat 3 alpha-hydroxysteroid dehydrogenase demonstrates contact residues influence the rate-determining step.
    Heredia VV, Cooper WC, Kruger RG, Jin Y, Penning TM.
    Biochemistry; 2004 May 18; 43(19):5832-41. PubMed ID: 15134457
    [Abstract] [Full Text] [Related]

  • 12. Crystal structures of two self-hydroxylating ribonucleotide reductase protein R2 mutants: structural basis for the oxygen-insertion step of hydroxylation reactions catalyzed by diiron proteins.
    Logan DT, deMaré F, Persson BO, Slaby A, Sjöberg BM, Nordlund P.
    Biochemistry; 1998 Jul 28; 37(30):10798-807. PubMed ID: 9692970
    [Abstract] [Full Text] [Related]

  • 13. Mutagenesis of a specificity-determining residue in tyrosine hydroxylase establishes that the enzyme is a robust phenylalanine hydroxylase but a fragile tyrosine hydroxylase.
    Daubner SC, Avila A, Bailey JO, Barrera D, Bermudez JY, Giles DH, Khan CA, Shaheen N, Thompson JW, Vasquez J, Oxley SP, Fitzpatrick PF.
    Biochemistry; 2013 Feb 26; 52(8):1446-55. PubMed ID: 23368961
    [Abstract] [Full Text] [Related]

  • 14. Oxygen and hydrogen isotope effects in an active site tyrosine to phenylalanine mutant of peptidylglycine alpha-hydroxylating monooxygenase: mechanistic implications.
    Francisco WA, Blackburn NJ, Klinman JP.
    Biochemistry; 2003 Feb 25; 42(7):1813-9. PubMed ID: 12590568
    [Abstract] [Full Text] [Related]

  • 15. Catalytic roles of arginine residues 82 and 92 of Escherichia coli 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: site-directed mutagenesis and biochemical studies.
    Li Y, Wu Y, Blaszczyk J, Ji X, Yan H.
    Biochemistry; 2003 Feb 18; 42(6):1581-8. PubMed ID: 12578371
    [Abstract] [Full Text] [Related]

  • 16. Site-directed mutagenesis of the putative distal helix of peroxygenase cytochrome P450.
    Matsunaga I, Ueda A, Sumimoto T, Ichihara K, Ayata M, Ogura H.
    Arch Biochem Biophys; 2001 Oct 01; 394(1):45-53. PubMed ID: 11566026
    [Abstract] [Full Text] [Related]

  • 17. Site-directed mutagenesis of putative active site residues of 5-enolpyruvylshikimate-3-phosphate synthase.
    Shuttleworth WA, Pohl ME, Helms GL, Jakeman DL, Evans JN.
    Biochemistry; 1999 Jan 05; 38(1):296-302. PubMed ID: 9890910
    [Abstract] [Full Text] [Related]

  • 18. Insights into the catalytic mechanisms of phenylalanine and tryptophan hydroxylase from kinetic isotope effects on aromatic hydroxylation.
    Pavon JA, Fitzpatrick PF.
    Biochemistry; 2006 Sep 12; 45(36):11030-7. PubMed ID: 16953590
    [Abstract] [Full Text] [Related]

  • 19. A mechanism for hydroxylation by tyrosine hydroxylase based on partitioning of substituted phenylalanines.
    Hillas PJ, Fitzpatrick PF.
    Biochemistry; 1996 Jun 04; 35(22):6969-75. PubMed ID: 8679520
    [Abstract] [Full Text] [Related]

  • 20. Effects of substitution of tryptophan 412 in the substrate activation pathway of yeast pyruvate decarboxylase.
    Li H, Jordan F.
    Biochemistry; 1999 Aug 03; 38(31):10004-12. PubMed ID: 10433707
    [Abstract] [Full Text] [Related]

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