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122 related items for PubMed ID: 10462533

  • 1. A novel domain of the inhibitory glycine receptor determining antagonist efficacies: further evidence for partial agonism resulting from self-inhibition.
    Schmieden V, Kuhse J, Betz H.
    Mol Pharmacol; 1999 Sep; 56(3):464-72. PubMed ID: 10462533
    [Abstract] [Full Text] [Related]

  • 2. Disruption of a putative intersubunit electrostatic bond enhances agonist efficacy at the human α1 glycine receptor.
    Welsh BT, Todorovic J, Kirson D, Allen HM, Bayly MD, Mihic SJ.
    Brain Res; 2017 Feb 15; 1657():148-155. PubMed ID: 27923639
    [Abstract] [Full Text] [Related]

  • 3. Characterization of two mutations, M287L and Q266I, in the α1 glycine receptor subunit that modify sensitivity to alcohols.
    Borghese CM, Blednov YA, Quan Y, Iyer SV, Xiong W, Mihic SJ, Zhang L, Lovinger DM, Trudell JR, Homanics GE, Harris RA.
    J Pharmacol Exp Ther; 2012 Feb 15; 340(2):304-16. PubMed ID: 22037201
    [Abstract] [Full Text] [Related]

  • 4. Pharmacology of the inhibitory glycine receptor: agonist and antagonist actions of amino acids and piperidine carboxylic acid compounds.
    Schmieden V, Betz H.
    Mol Pharmacol; 1995 Nov 15; 48(5):919-27. PubMed ID: 7476923
    [Abstract] [Full Text] [Related]

  • 5. Kinetic and mutational analysis of Zn2+ modulation of recombinant human inhibitory glycine receptors.
    Laube B, Kuhse J, Betz H.
    J Physiol; 2000 Jan 15; 522 Pt 2(Pt 2):215-30. PubMed ID: 10639099
    [Abstract] [Full Text] [Related]

  • 6. Hyperekplexia mutations of the glycine receptor unmask the inhibitory subsite for beta-amino-acids.
    Laube B, Langosch D, Betz H, Schmieden V.
    Neuroreport; 1995 Apr 19; 6(6):897-900. PubMed ID: 7542038
    [Abstract] [Full Text] [Related]

  • 7. Differential agonist sensitivity of glycine receptor alpha2 subunit splice variants.
    Miller PS, Harvey RJ, Smart TG.
    Br J Pharmacol; 2004 Sep 19; 143(1):19-26. PubMed ID: 15302677
    [Abstract] [Full Text] [Related]

  • 8. Mutation of glycine receptor subunit creates beta-alanine receptor responsive to GABA.
    Schmieden V, Kuhse J, Betz H.
    Science; 1993 Oct 08; 262(5131):256-8. PubMed ID: 8211147
    [Abstract] [Full Text] [Related]

  • 9. The M4 transmembrane segment contributes to agonist efficacy differences between alpha1 and alpha3 glycine receptors.
    Chen X, Webb TI, Lynch JW.
    Mol Membr Biol; 2009 Aug 08; 26(5):321-32. PubMed ID: 19626554
    [Abstract] [Full Text] [Related]

  • 10. Activation of human alpha1 and alpha2 homomeric glycine receptors by taurine and GABA.
    De Saint Jan D, David-Watine B, Korn H, Bregestovski P.
    J Physiol; 2001 Sep 15; 535(Pt 3):741-55. PubMed ID: 11559772
    [Abstract] [Full Text] [Related]

  • 11. Propofol restores the function of "hyperekplexic" mutant glycine receptors in Xenopus oocytes and mice.
    O'Shea SM, Becker L, Weiher H, Betz H, Laube B.
    J Neurosci; 2004 Mar 03; 24(9):2322-7. PubMed ID: 14999083
    [Abstract] [Full Text] [Related]

  • 12. Insights into the structural basis for zinc inhibition of the glycine receptor.
    Nevin ST, Cromer BA, Haddrill JL, Morton CJ, Parker MW, Lynch JW.
    J Biol Chem; 2003 Aug 01; 278(31):28985-92. PubMed ID: 12740384
    [Abstract] [Full Text] [Related]

  • 13. Agonist pharmacology of neonatal and adult glycine receptor alpha subunits: identification of amino acid residues involved in taurine activation.
    Schmieden V, Kuhse J, Betz H.
    EMBO J; 1992 Jun 01; 11(6):2025-32. PubMed ID: 1376243
    [Abstract] [Full Text] [Related]

  • 14. Probing the pharmacological properties of distinct subunit interfaces within heteromeric glycine receptors reveals a functional ββ agonist-binding site.
    Dutertre S, Drwal M, Laube B, Betz H.
    J Neurochem; 2012 Jul 01; 122(1):38-47. PubMed ID: 22486198
    [Abstract] [Full Text] [Related]

  • 15. Different binding modes of tropeines mediating inhibition and potentiation of alpha1 glycine receptors.
    Maksay G, Laube B, Schemm R, Grudzinska J, Drwal M, Betz H.
    J Neurochem; 2009 Jun 01; 109(6):1725-32. PubMed ID: 19383091
    [Abstract] [Full Text] [Related]

  • 16. Characterization of a glycine receptor domain that controls the binding and gating mechanisms of the beta-amino acid agonist, taurine.
    Han NL, Haddrill JL, Lynch JW.
    J Neurochem; 2001 Nov 01; 79(3):636-47. PubMed ID: 11701767
    [Abstract] [Full Text] [Related]

  • 17. Mutations within the agonist-binding site convert the homomeric alpha1 glycine receptor into a Zn2+-activated chloride channel.
    Grudzinska J, Schumann T, Schemm R, Betz H, Laube B.
    Channels (Austin); 2008 Nov 01; 2(1):13-8. PubMed ID: 18690053
    [Abstract] [Full Text] [Related]

  • 18. Comparison of taurine- and glycine-induced conformational changes in the M2-M3 domain of the glycine receptor.
    Han NL, Clements JD, Lynch JW.
    J Biol Chem; 2004 May 07; 279(19):19559-65. PubMed ID: 14981077
    [Abstract] [Full Text] [Related]

  • 19. Identification of an inhibitory Zn2+ binding site on the human glycine receptor alpha1 subunit.
    Harvey RJ, Thomas P, James CH, Wilderspin A, Smart TG.
    J Physiol; 1999 Oct 01; 520 Pt 1(Pt 1):53-64. PubMed ID: 10517800
    [Abstract] [Full Text] [Related]

  • 20. Manipulations of extracellular Loop 2 in α1 GlyR ultra-sensitive ethanol receptors (USERs) enhance receptor sensitivity to isoflurane, ethanol, and lidocaine, but not propofol.
    Naito A, Muchhala KH, Trang J, Asatryan L, Trudell JR, Homanics GE, Alkana RL, Davies DL.
    Neuroscience; 2015 Jun 25; 297():68-77. PubMed ID: 25827497
    [Abstract] [Full Text] [Related]

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