These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Journal Abstract Search

219 related items for PubMed ID: 10464018

  • 1. Synthesis and evaluation of 3-trifluoromethyl-7-substituted-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Grunewald GL, Caldwell TM, Li Q, Criscione KR.
    J Med Chem; 1999 Aug 26; 42(17):3315-23. PubMed ID: 10464018
    [Abstract] [Full Text] [Related]

  • 2. 3,7-Disubstituted-1,2,3,4-tetrahydroisoquinolines display remarkable potency and selectivity as inhibitors of phenylethanolamine N-methyltransferase versus the alpha2-adrenoceptor.
    Grunewald GL, Dahanukar VH, Teoh B, Criscione KR.
    J Med Chem; 1999 Jun 03; 42(11):1982-90. PubMed ID: 10354406
    [Abstract] [Full Text] [Related]

  • 3. Synthesis, biochemical evaluation, and classical and three-dimensional quantitative structure-activity relationship studies of 7-substituted-1,2,3,4-tetrahydroisoquinolines and their relative affinities toward phenylethanolamine N-methyltransferase and the alpha2-adrenoceptor.
    Grunewald GL, Dahanukar VH, Jalluri RK, Criscione KR.
    J Med Chem; 1999 Jan 14; 42(1):118-34. PubMed ID: 9888838
    [Abstract] [Full Text] [Related]

  • 4.
    ; . PubMed ID:
    [No Abstract] [Full Text] [Related]

  • 5. Synthesis and biochemical evaluation of 3-fluoromethyl-1,2,3, 4-tetrahydroisoquinolines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Grunewald GL, Caldwell TM, Li Q, Slavica M, Criscione KR, Borchardt RT, Wang W.
    J Med Chem; 1999 Sep 09; 42(18):3588-601. PubMed ID: 10479290
    [Abstract] [Full Text] [Related]

  • 6. Examination of the role of the acidic hydrogen in imparting selectivity of 7-(aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline (SK&F 29661) toward inhibition of phenylethanolamine N-methyltransferase vs the alpha 2-adrenoceptor.
    Grunewald GL, Dahanukar VH, Caldwell TM, Criscione KR.
    J Med Chem; 1997 Dec 05; 40(25):3997-4005. PubMed ID: 9406590
    [Abstract] [Full Text] [Related]

  • 7. 3-hydroxymethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinoline inhibitors of phenylethanolamine N-methyltransferase that display remarkable potency and selectivity.
    Grunewald GL, Romero FA, Criscione KR.
    J Med Chem; 2005 Jan 13; 48(1):134-40. PubMed ID: 15634007
    [Abstract] [Full Text] [Related]

  • 8. Exploring the active site of phenylethanolamine N-methyltransferase with 3-hydroxyethyl- and 3-hydroxypropyl-7-substituted-1,2,3,4-tetrahydroisoquinolines.
    Grunewald GL, Romero FA, Seim MR, Criscione KR, Deupree JD, Spackman CC, Bylund DB.
    Bioorg Med Chem Lett; 2005 Feb 15; 15(4):1143-7. PubMed ID: 15686930
    [Abstract] [Full Text] [Related]

  • 9. Effects of a 3-alkyl-, 4-hydroxy- and/or 8-aromatic-substituent on the phenylethanolamine N-methyltransferase inhibitor potency and alpha2-adrenoceptor affinity of 2,3,4,5-tetrahydro-1H-2-benzazepines.
    Grunewald GL, Dahanukar VH, Criscione KR.
    Bioorg Med Chem; 2001 Aug 15; 9(8):1957-65. PubMed ID: 11504632
    [Abstract] [Full Text] [Related]

  • 10. Synthesis and evaluation of 4-fluoro-8-substituted-2,3,4,5-tetrahydro-1H-2-benzazapines as selective inhibitors of phenylethanolamine N-methyltransferase versus the alpha(2)-adrenoceptor.
    Grunewald GL, Caldwell TM, Li Q, Criscione KR.
    J Med Chem; 2001 Aug 16; 44(17):2849-56. PubMed ID: 11495596
    [Abstract] [Full Text] [Related]

  • 11. Inhibitors of phenylethanolamine N-methyltransferase that are predicted to penetrate the blood-brain barrier: design, synthesis, and evaluation of 3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines that possess low affinity toward the alpha2-adrenoceptor.
    Romero FA, Vodonick SM, Criscione KR, McLeish MJ, Grunewald GL.
    J Med Chem; 2004 Aug 26; 47(18):4483-93. PubMed ID: 15317460
    [Abstract] [Full Text] [Related]

  • 12. Exploring the active site of phenylethanolamine N-methyltransferase: 3-alkyl-7-substituted-1,2,3,4-tetrahydroisoquinoline inhibitors.
    Grunewald GL, Romero FA, Chieu AD, Fincham KJ, Bhat SR, Criscione KR.
    Bioorg Med Chem; 2005 Feb 15; 13(4):1261-73. PubMed ID: 15670935
    [Abstract] [Full Text] [Related]

  • 13. Nanomolar inhibitors of CNS epinephrine biosynthesis: (R)-(+)-3-fluoromethyl-7-(N-substituted aminosulfonyl)-1,2,3,4-tetrahydroisoquinolines as potent and highly selective inhibitors of phenylethanolamine N-methyltransferase1.
    Grunewald GL, Romero FA, Criscione KR.
    J Med Chem; 2005 Mar 24; 48(6):1806-12. PubMed ID: 15771426
    [Abstract] [Full Text] [Related]

  • 14. Inhibitors of phenylethanolamine N-methyltransferase devoid of alpha2-adrenoceptor affinity.
    Grunewald GL, Lu J, Criscione KR, Okoro CO.
    Bioorg Med Chem Lett; 2005 Dec 01; 15(23):5319-23. PubMed ID: 16169723
    [Abstract] [Full Text] [Related]

  • 15. Effect of ring size or an additional heteroatom on the potency and selectivity of bicyclic benzylamine-type inhibitors of phenylethanolamine N-methyltransferase.
    Grunewald GL, Dahanukar VH, Ching P, Criscione KR.
    J Med Chem; 1996 Aug 30; 39(18):3539-46. PubMed ID: 8784452
    [Abstract] [Full Text] [Related]

  • 16. Application of the Goldilocks effect to the design of potent and selective inhibitors of phenylethanolamine N-methyltransferase: balancing pKa and steric effects in the optimization of 3-methyl-1,2,3,4-tetrahydroisoquinoline inhibitors by beta-fluorination.
    Grunewald GL, Seim MR, Lu J, Makboul M, Criscione KR.
    J Med Chem; 2006 May 18; 49(10):2939-52. PubMed ID: 16686536
    [Abstract] [Full Text] [Related]

  • 17. Assessment of the functional role of brain adrenergic neurons: chronic effects of phenylethanolamine N-methyltransferase inhibitors and alpha adrenergic receptor antagonists on brain norepinephrine metabolism.
    Stolk JM, Vantini G, Perry BD, Guchhait RB, U'Prichard DC.
    J Pharmacol Exp Ther; 1984 Sep 18; 230(3):577-86. PubMed ID: 6147403
    [Abstract] [Full Text] [Related]

  • 18. Comparison of the binding of 3-fluoromethyl-7-sulfonyl-1,2,3,4-tetrahydroisoquinolines with their isosteric sulfonamides to the active site of phenylethanolamine N-methyltransferase.
    Grunewald GL, Seim MR, Regier RC, Martin JL, Gee CL, Drinkwater N, Criscione KR.
    J Med Chem; 2006 Sep 07; 49(18):5424-33. PubMed ID: 16942016
    [Abstract] [Full Text] [Related]

  • 19. The blockade of alpha 2-adrenoceptors by the PNMT inhibitaor SK&F 64139.
    Goldstein M, Saito M, Lew JY, Hieble JP, Pendleton RG.
    Eur J Pharmacol; 1980 Oct 17; 67(2-3):305-8. PubMed ID: 6109637
    [Abstract] [Full Text] [Related]

  • 20. Studies on the adrenergic receptor specificity of inhibitors of phenylethanolamine N-methyltransferase.
    Pendleton RG, Hieble JP.
    Res Commun Chem Pathol Pharmacol; 1981 Dec 17; 34(3):399-408. PubMed ID: 6119751
    [Abstract] [Full Text] [Related]

    Page: [Next] [New Search]
    of 11.