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149 related items for PubMed ID: 10464027

  • 1. Structure-activity relationship of N-(phenylalkyl)cinnamides as novel NR2B subtype-selective NMDA receptor antagonists.
    Tamiz AP, Cai SX, Zhou ZL, Yuen PW, Schelkun RM, Whittemore ER, Weber E, Woodward RM, Keana JF.
    J Med Chem; 1999 Aug 26; 42(17):3412-20. PubMed ID: 10464027
    [Abstract] [Full Text] [Related]

  • 2. Structure-activity relationships for a series of bis(phenylalkyl)amines: potent subtype-selective inhibitors of N-methyl-D-aspartate receptors.
    Tamiz AP, Whittemore ER, Zhou ZL, Huang JC, Drewe JA, Chen JC, Cai SX, Weber E, Woodward RM, Keana JF.
    J Med Chem; 1998 Aug 27; 41(18):3499-506. PubMed ID: 9719603
    [Abstract] [Full Text] [Related]

  • 3. Antagonism of N-methyl-D-aspartate receptors by sigma site ligands: potency, subtype-selectivity and mechanisms of inhibition.
    Whittemore ER, Ilyin VI, Woodward RM.
    J Pharmacol Exp Ther; 1997 Jul 27; 282(1):326-38. PubMed ID: 9223571
    [Abstract] [Full Text] [Related]

  • 4. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors.
    Williams K.
    Mol Pharmacol; 1993 Oct 27; 44(4):851-9. PubMed ID: 7901753
    [Abstract] [Full Text] [Related]

  • 5. Subtype-selective inhibition of N-methyl-D-aspartate receptors by haloperidol.
    Ilyin VI, Whittemore ER, Guastella J, Weber E, Woodward RM.
    Mol Pharmacol; 1996 Dec 27; 50(6):1541-50. PubMed ID: 8967976
    [Abstract] [Full Text] [Related]

  • 6. Subtype-selective N-methyl-D-aspartate receptor antagonists: synthesis and biological evaluation of 1-(arylalkynyl)-4-benzylpiperidines.
    Wright JL, Gregory TF, Bigge CF, Boxer PA, Serpa K, Meltzer LT, Wise LD, Cai SX, Hawkinson JE, Konkoy CS, Whittemore ER, Woodward RM, Zhou ZL.
    J Med Chem; 1999 Jul 01; 42(13):2469-77. PubMed ID: 10395488
    [Abstract] [Full Text] [Related]

  • 7. Differing effects of N-methyl-D-aspartate receptor subtype selective antagonists on dyskinesias in levodopa-treated 1-methyl-4-phenyl-tetrahydropyridine monkeys.
    Blanchet PJ, Konitsiotis S, Whittemore ER, Zhou ZL, Woodward RM, Chase TN.
    J Pharmacol Exp Ther; 1999 Sep 01; 290(3):1034-40. PubMed ID: 10454475
    [Abstract] [Full Text] [Related]

  • 8. Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.
    Cai SX, Kher SM, Zhou ZL, Ilyin V, Espitia SA, Tran M, Hawkinson JE, Woodward RM, Weber E, Keana JF.
    J Med Chem; 1997 Feb 28; 40(5):730-8. PubMed ID: 9057859
    [Abstract] [Full Text] [Related]

  • 9. Synthesis of N-substituted 4-(4-hydroxyphenyl)piperidines, 4-(4-hydroxybenzyl)piperidines, and (+/-)-3-(4-hydroxyphenyl)pyrrolidines: selective antagonists at the 1A/2B NMDA receptor subtype.
    Guzikowski AP, Tamiz AP, Acosta-Burruel M, Hong-Bae S, Cai SX, Hawkinson JE, Keana JF, Kesten SR, Shipp CT, Tran M, Whittemore ER, Woodward RM, Wright JL, Zhou ZL.
    J Med Chem; 2000 Mar 09; 43(5):984-94. PubMed ID: 10715162
    [Abstract] [Full Text] [Related]

  • 10. Equilibrium constants for (R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid (NVP-AAM077) acting at recombinant NR1/NR2A and NR1/NR2B N-methyl-D-aspartate receptors: Implications for studies of synaptic transmission.
    Frizelle PA, Chen PE, Wyllie DJ.
    Mol Pharmacol; 2006 Sep 09; 70(3):1022-32. PubMed ID: 16778008
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site.
    Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Lü Y, Hawkinson JE, Woodward RM, Weber E, Keana JF.
    J Med Chem; 1996 Aug 16; 39(17):3248-55. PubMed ID: 8765507
    [Abstract] [Full Text] [Related]

  • 12. Antagonist properties of the stereoisomers of ifenprodil at NR1A/NR2A and NR1A/NR2B subtypes of the NMDA receptor expressed in Xenopus oocytes.
    Avenet P, Léonardon J, Besnard F, Graham D, Frost J, Depoortere H, Langer SZ, Scatton B.
    Eur J Pharmacol; 1996 Jan 25; 296(2):209-13. PubMed ID: 8838458
    [Abstract] [Full Text] [Related]

  • 13. In vitro characterization of novel NR2B selective NMDA receptor antagonists.
    Kiss L, Cheng G, Bednar B, Bednar RA, Bennett PB, Kane SA, McIntyre CJ, McCauley JA, Koblan KS.
    Neurochem Int; 2005 May 25; 46(6):453-64. PubMed ID: 15769547
    [Abstract] [Full Text] [Related]

  • 14. Pharmacological characterization of Ro 63-1908 (1-[2-(4-hydroxy-phenoxy)-ethyl]-4-(4-methyl-benzyl)-piperidin-4-ol), a novel subtype-selective N-methyl-D-aspartate antagonist.
    Gill R, Alanine A, Bourson A, Buttelmann B, Fischer G, Heitz MP, Kew JN, Levet-Trafit B, Lorez HP, Malherbe P, Miss MT, Mutel V, Pinard E, Roever S, Schmitt M, Trube G, Wybrecht R, Wyler R, Kemp JA.
    J Pharmacol Exp Ther; 2002 Sep 25; 302(3):940-8. PubMed ID: 12183650
    [Abstract] [Full Text] [Related]

  • 15. Inducible expression and pharmacological characterization of recombinant rat NR1a/NR2A NMDA receptors.
    Kurkó D, Dezso P, Boros A, Kolok S, Fodor L, Nagy J, Szombathelyi Z.
    Neurochem Int; 2005 Apr 25; 46(5):369-79. PubMed ID: 15737435
    [Abstract] [Full Text] [Related]

  • 16. Antagonist properties of polyamines and bis(ethyl)polyamines at N-methyl-D-aspartate receptors.
    Igarashi K, Williams K.
    J Pharmacol Exp Ther; 1995 Mar 25; 272(3):1101-9. PubMed ID: 7891322
    [Abstract] [Full Text] [Related]

  • 17. Cloning and functional characterization of human heteromeric N-methyl-D-aspartate receptors.
    Hess SD, Daggett LP, Crona J, Deal C, Lu CC, Urrutia A, Chavez-Noriega L, Ellis SB, Johnson EC, Veliçelebi G.
    J Pharmacol Exp Ther; 1996 Aug 25; 278(2):808-16. PubMed ID: 8768735
    [Abstract] [Full Text] [Related]

  • 18. Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors.
    Kloda A, Clements JD, Lewis RJ, Adams DJ.
    Mol Pharmacol; 2004 Jun 25; 65(6):1386-96. PubMed ID: 15155832
    [Abstract] [Full Text] [Related]

  • 19. Substitution for PCP, disruption of prepulse inhibition and hyperactivity induced by N-methyl-D-aspartate receptor antagonists: preferential involvement of the NR2B rather than NR2A subunit.
    Chaperon F, Müller W, Auberson YP, Tricklebank MD, Neijt HC.
    Behav Pharmacol; 2003 Sep 25; 14(5-6):477-87. PubMed ID: 14501261
    [Abstract] [Full Text] [Related]

  • 20. Native N-methyl-D-aspartate receptors containing NR2A and NR2B subunits have pharmacologically distinct competitive antagonist binding sites.
    Christie JM, Jane DE, Monaghan DT.
    J Pharmacol Exp Ther; 2000 Mar 25; 292(3):1169-74. PubMed ID: 10688637
    [Abstract] [Full Text] [Related]

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