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100 related items for PubMed ID: 10489446

  • 1. Crystal structure of epidoxorubicin-formaldehyde virtual crosslink of DNA and evidence for its formation in human breast-cancer cells.
    Podell ER, Harrington DJ, Taatjes DJ, Koch TH.
    Acta Crystallogr D Biol Crystallogr; 1999 Sep; 55(Pt 9):1516-23. PubMed ID: 10489446
    [Abstract] [Full Text] [Related]

  • 2. Epidoxoform: a hydrolytically more stable anthracycline-formaldehyde conjugate toxic to resistant tumor cells.
    Taatjes DJ, Fenick DJ, Koch TH.
    J Med Chem; 1998 Apr 09; 41(8):1306-14. PubMed ID: 9548820
    [Abstract] [Full Text] [Related]

  • 3. Nuclear targeting and nuclear retention of anthracycline-formaldehyde conjugates implicates DNA covalent bonding in the cytotoxic mechanism of anthracyclines.
    Taatjes DJ, Fenick DJ, Koch TH.
    Chem Res Toxicol; 1999 Jul 09; 12(7):588-96. PubMed ID: 10409398
    [Abstract] [Full Text] [Related]

  • 4. Facile formation of a crosslinked adduct between DNA and the daunorubicin derivative MAR70 mediated by formaldehyde: molecular structure of the MAR70-d(CGTnACG) covalent adduct.
    Gao YG, Liaw YC, Li YK, van der Marel GA, van Boom JH, Wang AH.
    Proc Natl Acad Sci U S A; 1991 Jun 01; 88(11):4845-9. PubMed ID: 2052564
    [Abstract] [Full Text] [Related]

  • 5. Nuclear targeting and retention of anthracycline antitumor drugs in sensitive and resistant tumor cells.
    Taatjes DJ, Koch TH.
    Curr Med Chem; 2001 Jan 01; 8(1):15-29. PubMed ID: 11172689
    [Abstract] [Full Text] [Related]

  • 6. Simultaneous incorporations of two anticancer drugs into DNA. The structures of formaldehyde-cross-linked adducts of daunorubicin-d(CG(araC)GCG) and doxorubicin-d(CA(araC)GTG) complexes at high resolution.
    Zhang H, Gao YG, van der Marel GA, van Boom JH, Wang AH.
    J Biol Chem; 1993 May 15; 268(14):10095-101. PubMed ID: 8486678
    [Abstract] [Full Text] [Related]

  • 7. Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the reverse Watson-Crick conformation: crystal structures of the WP401-TGGCCG and WP401-CGG[br5C]CG complexes.
    Dutta R, Gao YG, Priebe W, Wang AH.
    Nucleic Acids Res; 1998 Jun 15; 26(12):3001-5. PubMed ID: 9611247
    [Abstract] [Full Text] [Related]

  • 8. Substitutions at C2' of daunosamine in the anticancer drug daunorubicin alter its DNA-binding sequence specificity.
    Gao YG, Priebe W, Wang AH.
    Eur J Biochem; 1996 Sep 01; 240(2):331-5. PubMed ID: 8841395
    [Abstract] [Full Text] [Related]

  • 9. Growth inhibition, nuclear uptake, and retention of anthracycline-formaldehyde conjugates in prostate cancer cells relative to clinical anthracyclines.
    Taatjes DJ, Koch TH.
    Anticancer Res; 1999 Sep 01; 19(2A):1201-8. PubMed ID: 10368676
    [Abstract] [Full Text] [Related]

  • 10. Doxoform and Daunoform: anthracycline-formaldehyde conjugates toxic to resistant tumor cells.
    Fenick DJ, Taatjes DJ, Koch TH.
    J Med Chem; 1997 Aug 01; 40(16):2452-61. PubMed ID: 9258351
    [Abstract] [Full Text] [Related]

  • 11. Evaluation of the epidoxorubicin--formaldehyde conjugate, epidoxoform, in a mouse mammary carcinoma model.
    Dernell WS, Powers BE, Taatjes DJ, Cogan P, Gaudiano G, Koch TH.
    Cancer Invest; 2002 Aug 01; 20(5-6):713-24. PubMed ID: 12197227
    [Abstract] [Full Text] [Related]

  • 12. Formaldehyde cross-links daunorubicin and DNA efficiently: HPLC and X-ray diffraction studies.
    Wang AH, Gao YG, Liaw YC, Li YK.
    Biochemistry; 1991 Apr 23; 30(16):3812-5. PubMed ID: 2018756
    [Abstract] [Full Text] [Related]

  • 13. Mass spectrometric measurement of formaldehyde generated in breast cancer cells upon treatment with anthracycline antitumor drugs.
    Kato S, Burke PJ, Fenick DJ, Taatjes DJ, Bierbaum VM, Koch TH.
    Chem Res Toxicol; 2000 Jun 23; 13(6):509-16. PubMed ID: 10858324
    [Abstract] [Full Text] [Related]

  • 14. Structure-based design of a new bisintercalating anthracycline antibiotic.
    Chaires JB, Leng F, Przewloka T, Fokt I, Ling YH, Perez-Soler R, Priebe W.
    J Med Chem; 1997 Jan 31; 40(3):261-6. PubMed ID: 9022792
    [Abstract] [Full Text] [Related]

  • 15. Redox pathway leading to the alkylation of DNA by the anthracycline, antitumor drugs adriamycin and daunomycin.
    Taatjes DJ, Gaudiano G, Resing K, Koch TH.
    J Med Chem; 1997 Apr 11; 40(8):1276-86. PubMed ID: 9111302
    [Abstract] [Full Text] [Related]

  • 16. The hydroxyl epimer of doxorubicin controls the rate of formation of cytotoxic anthracycline-DNA adducts.
    Forrest RA, Swift LP, Evison BJ, Rephaeli A, Nudelman A, Phillips DR, Cutts SM.
    Cancer Chemother Pharmacol; 2013 Mar 11; 71(3):809-16. PubMed ID: 23263186
    [Abstract] [Full Text] [Related]

  • 17. Production of formaldehyde and DNA-adriamycin or DNA-daunomycin adducts, initiated through redox chemistry of dithiothreitol/iron, xanthine oxidase/NADH/iron, or glutathione/iron.
    Taatjes DJ, Gaudiano G, Koch TH.
    Chem Res Toxicol; 1997 Sep 11; 10(9):953-61. PubMed ID: 9305576
    [Abstract] [Full Text] [Related]

  • 18. Binding of two novel bisdaunorubicins to DNA studied by NMR spectroscopy.
    Robinson H, Priebe W, Chaires JB, Wang AH.
    Biochemistry; 1997 Jul 22; 36(29):8663-70. PubMed ID: 9289011
    [Abstract] [Full Text] [Related]

  • 19. Release of the cyano moiety in the crystal structure of N-cyanomethyl-N-(2-methoxyethyl)-daunomycin complexed with d(CGATCG).
    Saminadin P, Dautant A, Mondon M, Langlois D'estaintot B, Courseille C, Précigoux G.
    Eur J Biochem; 2000 Jan 22; 267(2):457-64. PubMed ID: 10632715
    [Abstract] [Full Text] [Related]

  • 20. Correlation of in Situ Oxazolidine Formation with Highly Synergistic Cytotoxicity and DNA Cross-Linking in Cancer Cells from Combinations of Doxorubicin and Formaldehyde.
    Barthel BL, Mooz EL, Wiener LE, Koch GG, Koch TH.
    J Med Chem; 2016 Mar 10; 59(5):2205-21. PubMed ID: 26881291
    [Abstract] [Full Text] [Related]

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