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358 related items for PubMed ID: 10493777

  • 1. Aldose and aldehyde reductases: structure-function studies on the coenzyme and inhibitor-binding sites.
    El-Kabbani O, Old SE, Ginell SL, Carper DA.
    Mol Vis; 1999 Sep 03; 5():20. PubMed ID: 10493777
    [Abstract] [Full Text] [Related]

  • 2. Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
    El-Kabbani O, Carbone V, Darmanin C, Oka M, Mitschler A, Podjarny A, Schulze-Briese C, Chung RP.
    J Med Chem; 2005 Aug 25; 48(17):5536-42. PubMed ID: 16107153
    [Abstract] [Full Text] [Related]

  • 3. Structure of rat aldose reductase-like protein AKR1B14 holoenzyme: Probing the role of His269 in coenzyme binding by site-directed mutagenesis.
    Sundaram K, Dhagat U, Endo S, Chung R, Matsunaga T, Hara A, El-Kabbani O.
    Bioorg Med Chem Lett; 2011 Jan 15; 21(2):801-4. PubMed ID: 21168333
    [Abstract] [Full Text] [Related]

  • 4. Kinetic and spectroscopic evidence for active site inhibition of human aldose reductase.
    Nakano T, Petrash JM.
    Biochemistry; 1996 Aug 27; 35(34):11196-202. PubMed ID: 8780524
    [Abstract] [Full Text] [Related]

  • 5. Aldehyde reductase: the role of C-terminal residues in defining substrate and cofactor specificities.
    Rees-Milton KJ, Jia Z, Green NC, Bhatia M, El-Kabbani O, Flynn TG.
    Arch Biochem Biophys; 1998 Jul 15; 355(2):137-44. PubMed ID: 9675019
    [Abstract] [Full Text] [Related]

  • 6. A 'specificity' pocket inferred from the crystal structures of the complexes of aldose reductase with the pharmaceutically important inhibitors tolrestat and sorbinil.
    Urzhumtsev A, Tête-Favier F, Mitschler A, Barbanton J, Barth P, Urzhumtseva L, Biellmann JF, Podjarny A, Moras D.
    Structure; 1997 May 15; 5(5):601-12. PubMed ID: 9195881
    [Abstract] [Full Text] [Related]

  • 7. Factorizing selectivity determinants of inhibitor binding toward aldose and aldehyde reductases: structural and thermodynamic properties of the aldose reductase mutant Leu300Pro-fidarestat complex.
    Petrova T, Steuber H, Hazemann I, Cousido-Siah A, Mitschler A, Chung R, Oka M, Klebe G, El-Kabbani O, Joachimiak A, Podjarny A.
    J Med Chem; 2005 Sep 08; 48(18):5659-65. PubMed ID: 16134934
    [Abstract] [Full Text] [Related]

  • 8. The C-terminal loop of aldehyde reductase determines the substrate and inhibitor specificity.
    Barski OA, Gabbay KH, Bohren KM.
    Biochemistry; 1996 Nov 12; 35(45):14276-80. PubMed ID: 8916913
    [Abstract] [Full Text] [Related]

  • 9. Structural features of the aldose reductase and aldehyde reductase inhibitor-binding sites.
    El-Kabbani O, Wilson DK, Petrash M, Quiocho FA.
    Mol Vis; 1998 Sep 29; 4():19. PubMed ID: 9756955
    [Abstract] [Full Text] [Related]

  • 10. Studies on the inhibitor-binding site of porcine aldehyde reductase: crystal structure of the holoenzyme-inhibitor ternary complex.
    el-Kabbani O, Carper DA, McGowan MH, Devedjiev Y, Rees-Milton KJ, Flynn TG.
    Proteins; 1997 Oct 29; 29(2):186-92. PubMed ID: 9329083
    [Abstract] [Full Text] [Related]

  • 11. Probing flexibility and "induced-fit" phenomena in aldose reductase by comparative crystal structure analysis and molecular dynamics simulations.
    Sotriffer CA, Krämer O, Klebe G.
    Proteins; 2004 Jul 01; 56(1):52-66. PubMed ID: 15162486
    [Abstract] [Full Text] [Related]

  • 12. High-resolution crystal structure of aldose reductase complexed with the novel sulfonyl-pyridazinone inhibitor exhibiting an alternative active site anchoring group.
    Steuber H, Zentgraf M, Podjarny A, Heine A, Klebe G.
    J Mol Biol; 2006 Feb 10; 356(1):45-56. PubMed ID: 16337231
    [Abstract] [Full Text] [Related]

  • 13. Ultrahigh resolution drug design. II. Atomic resolution structures of human aldose reductase holoenzyme complexed with Fidarestat and Minalrestat: implications for the binding of cyclic imide inhibitors.
    El-Kabbani O, Darmanin C, Schneider TR, Hazemann I, Ruiz F, Oka M, Joachimiak A, Schulze-Briese C, Tomizaki T, Mitschler A, Podjarny A.
    Proteins; 2004 Jun 01; 55(4):805-13. PubMed ID: 15146479
    [Abstract] [Full Text] [Related]

  • 14. Structure of aldehyde reductase in ternary complex with a 5-arylidene-2,4-thiazolidinedione aldose reductase inhibitor.
    Carbone V, Giglio M, Chung R, Huyton T, Adams J, Maccari R, Ottana R, Hara A, El-Kabbani O.
    Eur J Med Chem; 2010 Mar 01; 45(3):1140-5. PubMed ID: 20036445
    [Abstract] [Full Text] [Related]

  • 15. X-ray structure of the V301L aldo-keto reductase 1B10 complexed with NADP(+) and the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity.
    Ruiz FX, Cousido-Siah A, Mitschler A, Farrés J, Parés X, Podjarny A.
    Chem Biol Interact; 2013 Feb 25; 202(1-3):178-85. PubMed ID: 23295227
    [Abstract] [Full Text] [Related]

  • 16. Structure of human aldose reductase holoenzyme in complex with statil: an approach to structure-based inhibitor design of the enzyme.
    El-Kabbani O, Ramsland P, Darmanin C, Chung RP, Podjarny A.
    Proteins; 2003 Feb 01; 50(2):230-8. PubMed ID: 12486717
    [Abstract] [Full Text] [Related]

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  • 18. The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
    Harrison DH, Bohren KM, Petsko GA, Ringe D, Gabbay KH.
    Biochemistry; 1997 Dec 23; 36(51):16134-40. PubMed ID: 9405046
    [Abstract] [Full Text] [Related]

  • 19. Merging the binding sites of aldose and aldehyde reductase for detection of inhibitor selectivity-determining features.
    Steuber H, Heine A, Podjarny A, Klebe G.
    J Mol Biol; 2008 Jun 20; 379(5):991-1016. PubMed ID: 18495158
    [Abstract] [Full Text] [Related]

  • 20. Aldose and aldehyde reductases: correlation of molecular modeling and mass spectrometric studies on the binding of inhibitors to the active site.
    El-Kabbani O, Rogniaux H, Barth P, Chung RP, Fletcher EV, Van Dorsselaer A, Podjarny A.
    Proteins; 2000 Nov 15; 41(3):407-14. PubMed ID: 11025551
    [Abstract] [Full Text] [Related]

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