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313 related items for PubMed ID: 10501657

  • 1. Developmental expression of wild-type and mutant presenilin-1 in hippocampal neurons from transgenic mice: evidence for novel species-specific properties of human presenilin-1.
    Lévesque L, Annaert W, Craessaerts K, Mathews PM, Seeger M, Nixon RA, Van Leuven F, Gandy S, Westaway D, St George-Hyslop P, De Strooper B, Fraser PE.
    Mol Med; 1999 Aug; 5(8):542-54. PubMed ID: 10501657
    [Abstract] [Full Text] [Related]

  • 2. Processing of wild-type and mutant familial Alzheimer's disease-associated presenilin-1 in cultured neurons.
    Weihl CC, Ghadge GD, Miller RJ, Roos RP.
    J Neurochem; 1999 Jul; 73(1):31-40. PubMed ID: 10386952
    [Abstract] [Full Text] [Related]

  • 3. The presenilin-1 familial Alzheimer disease mutant P117L impairs neurogenesis in the hippocampus of adult mice.
    Wen PH, Hof PR, Chen X, Gluck K, Austin G, Younkin SG, Younkin LH, DeGasperi R, Gama Sosa MA, Robakis NK, Haroutunian V, Elder GA.
    Exp Neurol; 2004 Aug; 188(2):224-37. PubMed ID: 15246822
    [Abstract] [Full Text] [Related]

  • 4. Neurons overexpressing mutant presenilin-1 are more sensitive to apoptosis induced by endoplasmic reticulum-Golgi stress.
    Terro F, Czech C, Esclaire F, Elyaman W, Yardin C, Baclet MC, Touchet N, Tremp G, Pradier L, Hugon J.
    J Neurosci Res; 2002 Aug 15; 69(4):530-9. PubMed ID: 12210846
    [Abstract] [Full Text] [Related]

  • 5. Presenilin 1 regulates the processing of beta-amyloid precursor protein C-terminal fragments and the generation of amyloid beta-protein in endoplasmic reticulum and Golgi.
    Xia W, Zhang J, Ostaszewski BL, Kimberly WT, Seubert P, Koo EH, Shen J, Selkoe DJ.
    Biochemistry; 1998 Nov 24; 37(47):16465-71. PubMed ID: 9843412
    [Abstract] [Full Text] [Related]

  • 6. Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease.
    Mathews PM, Cataldo AM, Kao BH, Rudnicki AG, Qin X, Yang JL, Jiang Y, Picciano M, Hulette C, Lippa CF, Bird TD, Nochlin D, Walter J, Haass C, Lévesque L, Fraser PE, Andreadis A, Nixon RA.
    Mol Med; 2000 Oct 24; 6(10):878-91. PubMed ID: 11126202
    [Abstract] [Full Text] [Related]

  • 7. Neuropathology of mice carrying mutant APP(swe) and/or PS1(M146L) transgenes: alterations in the p75(NTR) cholinergic basal forebrain septohippocampal pathway.
    Jaffar S, Counts SE, Ma SY, Dadko E, Gordon MN, Morgan D, Mufson EJ.
    Exp Neurol; 2001 Aug 24; 170(2):227-43. PubMed ID: 11476589
    [Abstract] [Full Text] [Related]

  • 8. Hyperaccumulation of FAD-linked presenilin 1 variants in vivo.
    Lee MK, Borchelt DR, Kim G, Thinakaran G, Slunt HH, Ratovitski T, Martin LJ, Kittur A, Gandy S, Levey AI, Jenkins N, Copeland N, Price DL, Sisodia SS.
    Nat Med; 1997 Jul 24; 3(7):756-60. PubMed ID: 9212102
    [Abstract] [Full Text] [Related]

  • 9. Presenilin transgenic mice as models of Alzheimer's disease.
    Elder GA, Gama Sosa MA, De Gasperi R, Dickstein DL, Hof PR.
    Brain Struct Funct; 2010 Mar 24; 214(2-3):127-43. PubMed ID: 19921519
    [Abstract] [Full Text] [Related]

  • 10. Neuronal expression and intracellular localization of presenilins in normal and Alzheimer disease brains.
    Huynh DP, Vinters HV, Ho DH, Ho VV, Pulst SM.
    J Neuropathol Exp Neurol; 1997 Sep 24; 56(9):1009-17. PubMed ID: 9291942
    [Abstract] [Full Text] [Related]

  • 11. Subcellular distribution and turnover of presenilins in transfected cells.
    Zhang J, Kang DE, Xia W, Okochi M, Mori H, Selkoe DJ, Koo EH.
    J Biol Chem; 1998 May 15; 273(20):12436-42. PubMed ID: 9575200
    [Abstract] [Full Text] [Related]

  • 12. Presenilin-1 mutations reduce cytoskeletal association, deregulate neurite growth, and potentiate neuronal dystrophy and tau phosphorylation.
    Pigino G, Pelsman A, Mori H, Busciglio J.
    J Neurosci; 2001 Feb 01; 21(3):834-42. PubMed ID: 11157069
    [Abstract] [Full Text] [Related]

  • 13. The Alzheimer-related gene presenilin 1 facilitates notch 1 in primary mammalian neurons.
    Berezovska O, Frosch M, McLean P, Knowles R, Koo E, Kang D, Shen J, Lu FM, Lux SE, Tonegawa S, Hyman BT.
    Brain Res Mol Brain Res; 1999 Jun 08; 69(2):273-80. PubMed ID: 10366748
    [Abstract] [Full Text] [Related]

  • 14. Cellular expression and proteolytic processing of presenilin proteins is developmentally regulated during neuronal differentiation.
    Capell A, Saffrich R, Olivo JC, Meyn L, Walter J, Grünberg J, Mathews P, Nixon R, Dotti C, Haass C.
    J Neurochem; 1997 Dec 08; 69(6):2432-40. PubMed ID: 9375676
    [Abstract] [Full Text] [Related]

  • 15. Expression of presenilin 1 and 2 (PS1 and PS2) in human and murine tissues.
    Lee MK, Slunt HH, Martin LJ, Thinakaran G, Kim G, Gandy SE, Seeger M, Koo E, Price DL, Sisodia SS.
    J Neurosci; 1996 Dec 01; 16(23):7513-25. PubMed ID: 8922407
    [Abstract] [Full Text] [Related]

  • 16. Formation of tau inclusions in knock-in mice with familial Alzheimer disease (FAD) mutation of presenilin 1 (PS1).
    Tanemura K, Chui DH, Fukuda T, Murayama M, Park JM, Akagi T, Tatebayashi Y, Miyasaka T, Kimura T, Hashikawa T, Nakano Y, Kudo T, Takeda M, Takashima A.
    J Biol Chem; 2006 Feb 24; 281(8):5037-41. PubMed ID: 16377636
    [Abstract] [Full Text] [Related]

  • 17. Dissociated phenotypes in presenilin transgenic mice define functionally distinct gamma-secretases.
    Mastrangelo P, Mathews PM, Chishti MA, Schmidt SD, Gu Y, Yang J, Mazzella MJ, Coomaraswamy J, Horne P, Strome B, Pelly H, Levesque G, Ebeling C, Jiang Y, Nixon RA, Rozmahel R, Fraser PE, St George-Hyslop P, Carlson GA, Westaway D.
    Proc Natl Acad Sci U S A; 2005 Jun 21; 102(25):8972-7. PubMed ID: 15951428
    [Abstract] [Full Text] [Related]

  • 18. Subcellular localization of presenilin 2 endoproteolytic C-terminal fragments.
    Tekirian TL, Merriam DE, Marshansky V, Miller J, Crowley AC, Chan H, Ausiello D, Brown D, Buxbaum JD, Xia W, Wasco W.
    Brain Res Mol Brain Res; 2001 Nov 30; 96(1-2):14-20. PubMed ID: 11731004
    [Abstract] [Full Text] [Related]

  • 19. Accumulation of proteolytic fragments of mutant presenilin 1 and accelerated amyloid deposition are co-regulated in transgenic mice.
    Borchelt DR, Lee MK, Gonzales V, Slunt HH, Ratovitski T, Jenkins NA, Copeland NG, Price DL, Sisodia SS.
    Neurobiol Aging; 2002 Nov 30; 23(2):171-7. PubMed ID: 11804700
    [Abstract] [Full Text] [Related]

  • 20. Developmental regulation of presenilin-1 processing in the brain suggests a role in neuronal differentiation.
    Hartmann H, Busciglio J, Baumann KH, Staufenbiel M, Yankner BA.
    J Biol Chem; 1997 Jun 06; 272(23):14505-8. PubMed ID: 9169406
    [Abstract] [Full Text] [Related]

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