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106 related items for PubMed ID: 10524275

  • 1. Synthesis and enzymology of modified N-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide++ + disulphides as alternative substrates for trypanothione reductase from Trypanosoma cruzi: Part 3.
    Yuen CT, Garforth J, Besheya T, Jaouhari R, McKie JH, Fairlamb AH, Douglas KT.
    Amino Acids; 1999; 17(2):175-83. PubMed ID: 10524275
    [Abstract] [Full Text] [Related]

  • 2. Synthesis of N-benzyloxycarbonyl-L-cysteinylglycine 3-dimethylaminopropylamide disulfide: a cheap and convenient new assay for trypanothione reductase.
    el-Waer A, Douglas KT, Smith K, Fairlamb AH.
    Anal Biochem; 1991 Oct; 198(1):212-6. PubMed ID: 1789428
    [Abstract] [Full Text] [Related]

  • 3. Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds.
    Jockers-Scherübl MC, Schirmer RH, Krauth-Siegel RL.
    Eur J Biochem; 1989 Mar 15; 180(2):267-72. PubMed ID: 2647489
    [Abstract] [Full Text] [Related]

  • 4. Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.
    Khan MO, Austin SE, Chan C, Yin H, Marks D, Vaghjiani SN, Kendrick H, Yardley V, Croft SL, Douglas KT.
    J Med Chem; 2000 Aug 10; 43(16):3148-56. PubMed ID: 10956223
    [Abstract] [Full Text] [Related]

  • 5. Site-directed mutagenesis of the redox-active cysteines of Trypanosoma cruzi trypanothione reductase.
    Borges A, Cunningham ML, Tovar J, Fairlamb AH.
    Eur J Biochem; 1995 Mar 15; 228(3):745-52. PubMed ID: 7737173
    [Abstract] [Full Text] [Related]

  • 6. Ajoene is an inhibitor and subversive substrate of human glutathione reductase and Trypanosoma cruzi trypanothione reductase: crystallographic, kinetic, and spectroscopic studies.
    Gallwitz H, Bonse S, Martinez-Cruz A, Schlichting I, Schumacher K, Krauth-Siegel RL.
    J Med Chem; 1999 Feb 11; 42(3):364-72. PubMed ID: 9986706
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of Trypanosoma cruzi trypanothione reductase by crystal violet.
    Moreno SN, Carnieri EG, Docampo R.
    Mol Biochem Parasitol; 1994 Oct 11; 67(2):313-20. PubMed ID: 7870135
    [Abstract] [Full Text] [Related]

  • 8. Crystal structure of Trypanosoma cruzi trypanothione reductase in complex with trypanothione, and the structure-based discovery of new natural product inhibitors.
    Bond CS, Zhang Y, Berriman M, Cunningham ML, Fairlamb AH, Hunter WN.
    Structure; 1999 Jan 15; 7(1):81-9. PubMed ID: 10368274
    [Abstract] [Full Text] [Related]

  • 9. Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.
    Krauth-Siegel RL, Enders B, Henderson GB, Fairlamb AH, Schirmer RH.
    Eur J Biochem; 1987 Apr 01; 164(1):123-8. PubMed ID: 3549299
    [Abstract] [Full Text] [Related]

  • 10. Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity.
    Stoll VS, Simpson SJ, Krauth-Siegel RL, Walsh CT, Pai EF.
    Biochemistry; 1997 May 27; 36(21):6437-47. PubMed ID: 9174360
    [Abstract] [Full Text] [Related]

  • 11. Substrate specificity of trypanothione reductase.
    Marsh IR, Bradley M.
    Eur J Biochem; 1997 Feb 01; 243(3):690-4. PubMed ID: 9057833
    [Abstract] [Full Text] [Related]

  • 12. Inhibiting effects of spermidine derivatives on Trypanosoma cruzi trypanothione reductase.
    O'Sullivan MC, Dalrymple DM, Zhou Q.
    J Enzyme Inhib; 1996 Oct 01; 11(2):97-114. PubMed ID: 9204399
    [Abstract] [Full Text] [Related]

  • 13. "Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease.
    Henderson GB, Ulrich P, Fairlamb AH, Rosenberg I, Pereira M, Sela M, Cerami A.
    Proc Natl Acad Sci U S A; 1988 Aug 01; 85(15):5374-8. PubMed ID: 3135548
    [Abstract] [Full Text] [Related]

  • 14. Substrate specificity of the flavoprotein trypanothione disulfide reductase from Crithidia fasciculata.
    Henderson GB, Fairlamb AH, Ulrich P, Cerami A.
    Biochemistry; 1987 Jun 02; 26(11):3023-7. PubMed ID: 3607007
    [Abstract] [Full Text] [Related]

  • 15. Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.
    Chan C, Yin H, Garforth J, McKie JH, Jaouhari R, Speers P, Douglas KT, Rock PJ, Yardley V, Croft SL, Fairlamb AH.
    J Med Chem; 1998 Jan 15; 41(2):148-56. PubMed ID: 9457238
    [Abstract] [Full Text] [Related]

  • 16. The crystal structure of trypanothione reductase from the human pathogen Trypanosoma cruzi at 2.3 A resolution.
    Zhang Y, Bond CS, Bailey S, Cunningham ML, Fairlamb AH, Hunter WN.
    Protein Sci; 1996 Jan 15; 5(1):52-61. PubMed ID: 8771196
    [Abstract] [Full Text] [Related]

  • 17. Compared recognition of di- and trisulfide substrates by glutathione and trypanothione reductases.
    Moutiez M, Aumercier M, Parmentier B, Tartar A, Sergheraert C.
    Biochim Biophys Acta; 1995 Oct 19; 1245(2):161-6. PubMed ID: 7492572
    [Abstract] [Full Text] [Related]

  • 18. The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of gamma-glutamyl-modified substrate analogues.
    el-Waer AF, Smith K, McKie JH, Benson T, Fairlamb AH, Douglas KT.
    Biochim Biophys Acta; 1993 Nov 10; 1203(1):93-8. PubMed ID: 8105896
    [Abstract] [Full Text] [Related]

  • 19. Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine.
    Garforth J, Yin H, McKie JH, Douglas KT, Fairlamb AH.
    J Enzyme Inhib; 1997 Aug 10; 12(3):161-73. PubMed ID: 9314113
    [Abstract] [Full Text] [Related]

  • 20. The synthesis and inhibitory activity of dethiotrypanothione and analogues against trypanothione reductase.
    Czechowicz JA, Wilhelm AK, Spalding MD, Larson AM, Engel LK, Alberg DG.
    J Org Chem; 2007 May 11; 72(10):3689-93. PubMed ID: 17439174
    [Abstract] [Full Text] [Related]

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