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Journal Abstract Search

672 related items for PubMed ID: 10525096

  • 1. Role of a potent inhibitory monoclonal antibody to cytochrome P-450 3A4 in assessment of human drug metabolism.
    Mei Q, Tang C, Assang C, Lin Y, Slaughter D, Rodrigues AD, Baillie TA, Rushmore TH, Shou M.
    J Pharmacol Exp Ther; 1999 Nov; 291(2):749-59. PubMed ID: 10525096
    [Abstract] [Full Text] [Related]

  • 2. Metabolism of 2,5-bis(trifluoromethyl)-7-benzyloxy-4-trifluoromethylcoumarin by human hepatic CYP isoforms: evidence for selectivity towards CYP3A4.
    Renwick AB, Lewis DF, Fulford S, Surry D, Williams B, Worboys PD, Cai X, Wang RW, Price RJ, Lake BG, Evans DC.
    Xenobiotica; 2001 Apr; 31(4):187-204. PubMed ID: 11465405
    [Abstract] [Full Text] [Related]

  • 3. Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate.
    Kobayashi K, Mimura N, Fujii H, Minami H, Sasaki Y, Shimada N, Chiba K.
    Clin Cancer Res; 2000 Aug; 6(8):3297-303. PubMed ID: 10955816
    [Abstract] [Full Text] [Related]

  • 4. Biotransformation of parathion in human liver: participation of CYP3A4 and its inactivation during microsomal parathion oxidation.
    Butler AM, Murray M.
    J Pharmacol Exp Ther; 1997 Feb; 280(2):966-73. PubMed ID: 9023313
    [Abstract] [Full Text] [Related]

  • 5. Differential selectivity of cytochrome P450 inhibitors against probe substrates in human and rat liver microsomes.
    Eagling VA, Tjia JF, Back DJ.
    Br J Clin Pharmacol; 1998 Feb; 45(2):107-14. PubMed ID: 9491822
    [Abstract] [Full Text] [Related]

  • 6. Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms.
    Renwick AB, Surry D, Price RJ, Lake BG, Evans DC.
    Xenobiotica; 2000 Oct; 30(10):955-69. PubMed ID: 11315104
    [Abstract] [Full Text] [Related]

  • 7. Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes.
    Yamazaki H, Shimada T.
    Arch Biochem Biophys; 1997 Oct 01; 346(1):161-9. PubMed ID: 9328296
    [Abstract] [Full Text] [Related]

  • 8. Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs.
    Nakajima M, Nakamura S, Tokudome S, Shimada N, Yamazaki H, Yokoi T.
    Drug Metab Dispos; 1999 Dec 01; 27(12):1381-91. PubMed ID: 10570018
    [Abstract] [Full Text] [Related]

  • 9. Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily.
    Gorski JC, Jones DR, Wrighton SA, Hall SD.
    Biochem Pharmacol; 1994 Jul 05; 48(1):173-82. PubMed ID: 8043020
    [Abstract] [Full Text] [Related]

  • 10. Different contributions of cytochrome P450 2C19 and 3A4 in the oxidation of omeprazole by human liver microsomes: effects of contents of these two forms in individual human samples.
    Yamazaki H, Inoue K, Shaw PM, Checovich WJ, Guengerich FP, Shimada T.
    J Pharmacol Exp Ther; 1997 Nov 05; 283(2):434-42. PubMed ID: 9353355
    [Abstract] [Full Text] [Related]

  • 11. CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes.
    Ramírez J, Innocenti F, Schuetz EG, Flockhart DA, Relling MV, Santucci R, Ratain MJ.
    Drug Metab Dispos; 2004 Sep 05; 32(9):930-6. PubMed ID: 15319333
    [Abstract] [Full Text] [Related]

  • 12. Role of cytochrome P450 3A4 in human metabolism of MK-639, a potent human immunodeficiency virus protease inhibitor.
    Chiba M, Hensleigh M, Nishime JA, Balani SK, Lin JH.
    Drug Metab Dispos; 1996 Mar 05; 24(3):307-14. PubMed ID: 8820421
    [Abstract] [Full Text] [Related]

  • 13. Metabolism of tauromustine in liver and lung microsomes from various species.
    Tuvesson H, Gunnarsson PO, Seidegård J.
    Xenobiotica; 1999 Aug 05; 29(8):783-92. PubMed ID: 10553719
    [Abstract] [Full Text] [Related]

  • 14. In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam.
    Tang J, Amin Usmani K, Hodgson E, Rose RL.
    Chem Biol Interact; 2004 Apr 15; 147(3):319-29. PubMed ID: 15135087
    [Abstract] [Full Text] [Related]

  • 15. Identification of CYP3A4 as the principal enzyme catalyzing mifepristone (RU 486) oxidation in human liver microsomes.
    Jang GR, Wrighton SA, Benet LZ.
    Biochem Pharmacol; 1996 Sep 13; 52(5):753-61. PubMed ID: 8765473
    [Abstract] [Full Text] [Related]

  • 16. Role of CYP3A4 in human hepatic diltiazem N-demethylation: inhibition of CYP3A4 activity by oxidized diltiazem metabolites.
    Sutton D, Butler AM, Nadin L, Murray M.
    J Pharmacol Exp Ther; 1997 Jul 13; 282(1):294-300. PubMed ID: 9223567
    [Abstract] [Full Text] [Related]

  • 17. Activation of phenacetin O-deethylase activity by alpha-naphthoflavone in human liver microsomes.
    Nakajima M, Kobayashi K, Oshima K, Shimada N, Tokudome S, Chiba K, Yokoi T.
    Xenobiotica; 1999 Sep 13; 29(9):885-98. PubMed ID: 10548449
    [Abstract] [Full Text] [Related]

  • 18. N,N-diethyl-2-[4-(phenylmethyl)phenoxy] ethanamine (DPPE) a chemopotentiating and cytoprotective agent in clinical trials: interaction with histamine at cytochrome P450 3A4 and other isozymes that metabolize antineoplastic drugs.
    Brandes LJ, Queen GM, LaBella FS.
    Cancer Chemother Pharmacol; 2000 Sep 13; 45(4):298-304. PubMed ID: 10755318
    [Abstract] [Full Text] [Related]

  • 19. Identification of human liver cytochrome P450 isoforms involved in the in vitro metabolism of cyclobenzaprine.
    Wang RW, Liu L, Cheng H.
    Drug Metab Dispos; 1996 Jul 13; 24(7):786-91. PubMed ID: 8818577
    [Abstract] [Full Text] [Related]

  • 20. Identification of human liver cytochrome P450 enzymes that metabolize the nonsedating antihistamine loratadine. Formation of descarboethoxyloratadine by CYP3A4 and CYP2D6.
    Yumibe N, Huie K, Chen KJ, Snow M, Clement RP, Cayen MN.
    Biochem Pharmacol; 1996 Jan 26; 51(2):165-72. PubMed ID: 8615885
    [Abstract] [Full Text] [Related]

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