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Journal Abstract Search

141 related items for PubMed ID: 10530940

  • 1. Imidazole substituted biphenyls: a new class of highly potent and in vivo active inhibitors of P450 17 as potential therapeutics for treatment of prostate cancer.
    Wachall BG, Hector M, Zhuang Y, Hartmann RW.
    Bioorg Med Chem; 1999 Sep; 7(9):1913-24. PubMed ID: 10530940
    [Abstract] [Full Text] [Related]

  • 2. Novel imidazolyl and triazolyl substituted biphenyl compounds: synthesis and evaluation as nonsteroidal inhibitors of human 17alpha-hydroxylase-C17, 20-lyase (P450 17).
    Zhuang Y, Wachall BG, Hartmann RW.
    Bioorg Med Chem; 2000 Jun; 8(6):1245-52. PubMed ID: 10896104
    [Abstract] [Full Text] [Related]

  • 3. Synthesis and evaluation of 17-aliphatic heterocycle-substituted steroidal inhibitors of 17alpha-hydroxylase/C17-20-lyase (P450 17).
    Hartmann RW, Hector M, Wachall BG, Palusczak A, Palzer M, Huch V, Veith M.
    J Med Chem; 2000 Nov 16; 43(23):4437-45. PubMed ID: 11087568
    [Abstract] [Full Text] [Related]

  • 4. Synthesis and evaluation of azole-substituted tetrahydronaphthalenes as inhibitors of P450 arom, P450 17, and P450 TxA2.
    Hartmann RW, Frotscher M, Ledergerber D, Wächter GA, Grün GL, Sergejew TF.
    Arch Pharm (Weinheim); 1996 May 16; 329(5):251-61. PubMed ID: 8779634
    [Abstract] [Full Text] [Related]

  • 5. Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Owen CP, Shahid I, Olusanjo MS, Patel CH, Dhanani S, Ahmed S.
    J Steroid Biochem Mol Biol; 2008 Jul 16; 111(1-2):117-27. PubMed ID: 18620055
    [Abstract] [Full Text] [Related]

  • 6. Tetrahydronaphthalenes: influence of heterocyclic substituents on inhibition of steroid enzymes P450 arom and P450 17.
    Wächter GA, Hartmann RW, Sergejew T, Grün GL, Ledergerber D.
    J Med Chem; 1996 Feb 16; 39(4):834-41. PubMed ID: 8632407
    [Abstract] [Full Text] [Related]

  • 7. Synthesis and evaluation of novel steroidal oxime inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase) and 5 alpha-reductase types 1 and 2.
    Hartmann RW, Hector M, Haidar S, Ehmer PB, Reichert W, Jose J.
    J Med Chem; 2000 Nov 02; 43(22):4266-77. PubMed ID: 11063622
    [Abstract] [Full Text] [Related]

  • 8. Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge.
    Hu Q, Negri M, Jahn-Hoffmann K, Zhuang Y, Olgen S, Bartels M, Müller-Vieira U, Lauterbach T, Hartmann RW.
    Bioorg Med Chem; 2008 Aug 15; 16(16):7715-27. PubMed ID: 18674917
    [Abstract] [Full Text] [Related]

  • 9. Novel 17-azolyl steroids, potent inhibitors of human cytochrome 17 alpha-hydroxylase-C17,20-lyase (P450(17) alpha): potential agents for the treatment of prostate cancer.
    Njar VC, Kato K, Nnane IP, Grigoryev DN, Long BJ, Brodie AM.
    J Med Chem; 1998 Mar 12; 41(6):902-12. PubMed ID: 9526564
    [Abstract] [Full Text] [Related]

  • 10. Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo.
    Haidar S, Ehmer PB, Barassin S, Batzl-Hartmann C, Hartmann RW.
    J Steroid Biochem Mol Biol; 2003 Apr 12; 84(5):555-62. PubMed ID: 12767280
    [Abstract] [Full Text] [Related]

  • 11. Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)).
    Owen CP, Dhanani S, Patel CH, Shahid I, Ahmed S.
    Bioorg Med Chem Lett; 2006 Aug 01; 16(15):4011-5. PubMed ID: 16750362
    [Abstract] [Full Text] [Related]

  • 12. Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls.
    Hille UE, Hu Q, Vock C, Negri M, Bartels M, Müller-Vieira U, Lauterbach T, Hartmann RW.
    Eur J Med Chem; 2009 Jul 01; 44(7):2765-75. PubMed ID: 19211174
    [Abstract] [Full Text] [Related]

  • 13. 17-Imidazolyl, pyrazolyl, and isoxazolyl androstene derivatives. Novel steroidal inhibitors of human cytochrome C17,20-lyase (P450(17 alpha).
    Ling YZ, Li JS, Liu Y, Kato K, Klus GT, Brodie A.
    J Med Chem; 1997 Sep 26; 40(20):3297-304. PubMed ID: 9379450
    [Abstract] [Full Text] [Related]

  • 14. C16 and C17 substituted derivatives of pregnenolone and progesterone as inhibitors of 17alpha-hydroxylase-C17, 20-lyase: synthesis and biological evaluation.
    Haidar S, Hartmann RW.
    Arch Pharm (Weinheim); 2002 Sep 26; 335(11-12):526-34. PubMed ID: 12596217
    [Abstract] [Full Text] [Related]

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  • 16. Effects of some novel inhibitors of C17,20-lyase and 5alpha-reductase in vitro and in vivo and their potential role in the treatment of prostate cancer.
    Nnane IP, Kato K, Liu Y, Lu Q, Wang X, Ling YZ, Brodie A.
    Cancer Res; 1998 Sep 01; 58(17):3826-32. PubMed ID: 9731491
    [Abstract] [Full Text] [Related]

  • 17. Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer.
    Pinto-Bazurco Mendieta MA, Negri M, Jagusch C, Müller-Vieira U, Lauterbach T, Hartmann RW.
    J Med Chem; 2008 Aug 28; 51(16):5009-18. PubMed ID: 18672868
    [Abstract] [Full Text] [Related]

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  • 19. Some 1-[(benzofuran-2-yl)methyl]imidazoles as inhibitors of 17 alpha-hydroxylase: 17, 20-lyase (P450 17) and their specificity patterns.
    Bahshwan SA, Owen CP, Nicholls PJ, Smith HJ, Ahmadi M.
    J Pharm Pharmacol; 1998 Oct 28; 50(10):1109-16. PubMed ID: 9821656
    [Abstract] [Full Text] [Related]

  • 20. Inhibition of p450 17 as a new strategy for the treatment of prostate cancer.
    Leroux F.
    Curr Med Chem; 2005 Oct 28; 12(14):1623-9. PubMed ID: 16022662
    [Abstract] [Full Text] [Related]

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