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180 related items for PubMed ID: 10559157

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  • 3. Enzymes catalyzing the early steps of clavulanic acid biosynthesis are encoded by two sets of paralogous genes in Streptomyces clavuligerus.
    Jensen SE, Elder KJ, Aidoo KA, Paradkar AS.
    Antimicrob Agents Chemother; 2000 Mar; 44(3):720-6. PubMed ID: 10681345
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  • 4. The claR gene of Streptomyces clavuligerus, encoding a LysR-type regulatory protein controlling clavulanic acid biosynthesis, is linked to the clavulanate-9-aldehyde reductase (car) gene.
    Pérez-Redondo R, Rodríguez-García A, Martín JF, Liras P.
    Gene; 1998 May 12; 211(2):311-21. PubMed ID: 9602162
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  • 5. An rplKDelta29-PALG-32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus.
    Gomez-Escribano JP, Liras P, Pisabarro A, Martín JF.
    Mol Microbiol; 2006 Aug 12; 61(3):758-70. PubMed ID: 16803595
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  • 7. Transcriptional Studies on a Streptomyces clavuligerus oppA2 Deletion Mutant: N-Acetylglycyl-Clavaminic Acid Is an Intermediate of Clavulanic Acid Biosynthesis.
    Álvarez-Álvarez R, Rodríguez-García A, Martínez-Burgo Y, Martín JF, Liras P.
    Appl Environ Microbiol; 2018 Nov 15; 84(22):. PubMed ID: 30194098
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  • 8. Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.
    Gomez-Escribano JP, Martín JF, Hesketh A, Bibb MJ, Liras P.
    Microbiology (Reading); 2008 Mar 15; 154(Pt 3):744-755. PubMed ID: 18310021
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  • 9. Glycerol utilization gene cluster in Streptomyces clavuligerus.
    Baños S, Pérez-Redondo R, Koekman B, Liras P.
    Appl Environ Microbiol; 2009 May 15; 75(9):2991-5. PubMed ID: 19286797
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  • 10. Transcriptomic analysis of Streptomyces clavuligerus ΔccaR::tsr: effects of the cephamycin C-clavulanic acid cluster regulator CcaR on global regulation.
    Alvarez-Álvarez R, Rodríguez-García A, Santamarta I, Pérez-Redondo R, Prieto-Domínguez A, Martínez-Burgo Y, Liras P.
    Microb Biotechnol; 2014 May 15; 7(3):221-31. PubMed ID: 24450885
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  • 11. A gene located downstream of the clavulanic acid gene cluster in Streptomyces clavuligerus ATCC 27064 encodes a putative response regulator that affects clavulanic acid production.
    Song JY, Kim ES, Kim DW, Jensen SE, Lee KJ.
    J Ind Microbiol Biotechnol; 2009 Feb 15; 36(2):301-11. PubMed ID: 19011915
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  • 12. A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds.
    Pérez-Llarena FJ, Liras P, Rodríguez-García A, Martín JF.
    J Bacteriol; 1997 Mar 15; 179(6):2053-9. PubMed ID: 9068654
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  • 13. The paralogous pairs of genes involved in clavulanic acid and clavam metabolite biosynthesis are differently regulated in Streptomyces clavuligerus.
    Tahlan K, Anders C, Jensen SE.
    J Bacteriol; 2004 Sep 15; 186(18):6286-97. PubMed ID: 15342599
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  • 14. Two oligopeptide-permease-encoding genes in the clavulanic acid cluster of Streptomyces clavuligerus are essential for production of the beta-lactamase inhibitor.
    Lorenzana LM, Pérez-Redondo R, Santamarta I, Martín JF, Liras P.
    J Bacteriol; 2004 Jun 15; 186(11):3431-8. PubMed ID: 15150229
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  • 15. Construction and analysis of ss-lactamase-inhibitory protein (BLIP) non-producer mutants of Streptomyces clavuligerus.
    Thai W, Paradkar AS, Jensen SE.
    Microbiology (Reading); 2001 Feb 15; 147(Pt 2):325-335. PubMed ID: 11158349
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  • 16. Expression of ccaR, encoding the positive activator of cephamycin C and clavulanic acid production in Streptomyces clavuligerus, is dependent on bldG.
    Bignell DR, Tahlan K, Colvin KR, Jensen SE, Leskiw BK.
    Antimicrob Agents Chemother; 2005 Apr 15; 49(4):1529-41. PubMed ID: 15793135
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  • 17. Applications of gene replacement technology to Streptomyces clavuligerus strain development for clavulanic acid production.
    Paradkar AS, Mosher RH, Anders C, Griffin A, Griffin J, Hughes C, Greaves P, Barton B, Jensen SE.
    Appl Environ Microbiol; 2001 May 15; 67(5):2292-7. PubMed ID: 11319114
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  • 18. Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus.
    Santamarta I, Pérez-Redondo R, Lorenzana LM, Martín JF, Liras P.
    Mol Microbiol; 2005 May 15; 56(3):824-35. PubMed ID: 15819635
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  • 19. The clavulanic acid biosynthetic cluster of Streptomyces clavuligerus: genetic organization of the region upstream of the car gene.
    Mellado E, Lorenzana LM, Rodrı Guez-Sáiz M, Dı Ez B, Liras P, Barredo JL.
    Microbiology (Reading); 2002 May 15; 148(Pt 5):1427-1438. PubMed ID: 11988517
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