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Journal Abstract Search

574 related items for PubMed ID: 10570018

  • 1. Azelastine N-demethylation by cytochrome P-450 (CYP)3A4, CYP2D6, and CYP1A2 in human liver microsomes: evaluation of approach to predict the contribution of multiple CYPs.
    Nakajima M, Nakamura S, Tokudome S, Shimada N, Yamazaki H, Yokoi T.
    Drug Metab Dispos; 1999 Dec; 27(12):1381-91. PubMed ID: 10570018
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  • 2. In vitro identification of the human cytochrome P-450 enzymes involved in the N-demethylation of azelastine.
    Imai T, Taketani M, Suzu T, Kusube K, Otagiri M.
    Drug Metab Dispos; 1999 Aug; 27(8):942-6. PubMed ID: 10421623
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  • 3. Evaluation of approach to predict the contribution of multiple cytochrome P450s in drug metabolism using relative activity factor: effects of the differences in expression levels of NADPH-cytochrome P450 reductase and cytochrome b(5) in the expression system and the differences in the marker activities.
    Nakajima M, Tane K, Nakamura S, Shimada N, Yamazaki H, Yokoi T.
    J Pharm Sci; 2002 Apr; 91(4):952-63. PubMed ID: 11948533
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  • 4. Inhibitory effects of azelastine and its metabolites on drug oxidation catalyzed by human cytochrome P-450 enzymes.
    Nakajima M, Ohyama K, Nakamura S, Shimada N, Yamazaki H, Yokoi T.
    Drug Metab Dispos; 1999 Jul; 27(7):792-7. PubMed ID: 10383922
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  • 8. Nortriptyline E-10-hydroxylation in vitro is mediated by human CYP2D6 (high affinity) and CYP3A4 (low affinity): implications for interactions with enzyme-inducing drugs.
    Venkatakrishnan K, von Moltke LL, Greenblatt DJ.
    J Clin Pharmacol; 1999 Jun; 39(6):567-77. PubMed ID: 10354960
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  • 10. CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam.
    Hesse LM, Venkatakrishnan K, von Moltke LL, Shader RI, Greenblatt DJ.
    Drug Metab Dispos; 2001 Feb; 29(2):133-40. PubMed ID: 11159802
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  • 11. Characterization of the human hepatic cytochromes P450 involved in the in vitro oxidation of clozapine.
    Tugnait M, Hawes EM, McKay G, Eichelbaum M, Midha KK.
    Chem Biol Interact; 1999 Apr 01; 118(2):171-89. PubMed ID: 10359460
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  • 18. Metabolism of methadone and levo-alpha-acetylmethadol (LAAM) by human intestinal cytochrome P450 3A4 (CYP3A4): potential contribution of intestinal metabolism to presystemic clearance and bioactivation.
    Oda Y, Kharasch ED.
    J Pharmacol Exp Ther; 2001 Sep 01; 298(3):1021-32. PubMed ID: 11504799
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  • 20. Oxidative metabolism of 5-methoxy-N,N-diisopropyltryptamine (Foxy) by human liver microsomes and recombinant cytochrome P450 enzymes.
    Narimatsu S, Yonemoto R, Saito K, Takaya K, Kumamoto T, Ishikawa T, Asanuma M, Funada M, Kiryu K, Naito S, Yoshida Y, Yamamoto S, Hanioka N.
    Biochem Pharmacol; 2006 Apr 28; 71(9):1377-85. PubMed ID: 16510126
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