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Journal Abstract Search

187 related items for PubMed ID: 10571245

  • 1. Comparison of the efficacy of 7-hydroxystaurosporine (UCN-01) and other staurosporine analogs to abrogate cisplatin-induced cell cycle arrest in human breast cancer cell lines.
    Lee SI, Brown MK, Eastman A.
    Biochem Pharmacol; 1999 Dec 01; 58(11):1713-21. PubMed ID: 10571245
    [Abstract] [Full Text] [Related]

  • 2. A novel indolocarbazole, ICP-1, abrogates DNA damage-induced cell cycle arrest and enhances cytotoxicity: similarities and differences to the cell cycle checkpoint abrogator UCN-01.
    Eastman A, Kohn EA, Brown MK, Rathman J, Livingstone M, Blank DH, Gribble GW.
    Mol Cancer Ther; 2002 Oct 01; 1(12):1067-78. PubMed ID: 12481430
    [Abstract] [Full Text] [Related]

  • 3. Enhancement of cisplatin-induced cytotoxicity by 7-hydroxystaurosporine (UCN-01), a new G2-checkpoint inhibitor.
    Bunch RT, Eastman A.
    Clin Cancer Res; 1996 May 01; 2(5):791-7. PubMed ID: 9816232
    [Abstract] [Full Text] [Related]

  • 4. UCN-01: a potent abrogator of G2 checkpoint function in cancer cells with disrupted p53.
    Wang Q, Fan S, Eastman A, Worland PJ, Sausville EA, O'Connor PM.
    J Natl Cancer Inst; 1996 Jul 17; 88(14):956-65. PubMed ID: 8667426
    [Abstract] [Full Text] [Related]

  • 5. 7-Hydroxystaurosporine (UCN-01) causes redistribution of proliferating cell nuclear antigen and abrogates cisplatin-induced S-phase arrest in Chinese hamster ovary cells.
    Bunch RT, Eastman A.
    Cell Growth Differ; 1997 Jul 17; 8(7):779-88. PubMed ID: 9218872
    [Abstract] [Full Text] [Related]

  • 6. UCN-01 selectively enhances mitomycin C cytotoxicity in p53 defective cells which is mediated through S and/or G(2) checkpoint abrogation.
    Sugiyama K, Shimizu M, Akiyama T, Tamaoki T, Yamaguchi K, Takahashi R, Eastman A, Akinaga S.
    Int J Cancer; 2000 Mar 01; 85(5):703-9. PubMed ID: 10699952
    [Abstract] [Full Text] [Related]

  • 7. Implications of p53 in growth arrest and apoptosis on combined treatment of human Mammary epithelial cells with topotecan and UCN-01.
    Redkar A, Mixter P, Daoud SS.
    J Exp Ther Oncol; 2004 Oct 01; 4(3):213-22. PubMed ID: 15724841
    [Abstract] [Full Text] [Related]

  • 8. Cell cycle-dependent potentiation of cisplatin by UCN-01 in non-small-cell lung carcinoma.
    Mack PC, Gandara DR, Lau AH, Lara PN, Edelman MJ, Gumerlock PH.
    Cancer Chemother Pharmacol; 2003 Apr 01; 51(4):337-48. PubMed ID: 12721762
    [Abstract] [Full Text] [Related]

  • 9. Defective p53 signaling in p53 wild-type tumors attenuates p21waf1 induction and cyclin B repression rendering them sensitive to Chk1 inhibitors that abrogate DNA damage-induced S and G2 arrest.
    Levesque AA, Fanous AA, Poh A, Eastman A.
    Mol Cancer Ther; 2008 Feb 01; 7(2):252-62. PubMed ID: 18281511
    [Abstract] [Full Text] [Related]

  • 10. Abrogation of the S phase DNA damage checkpoint results in S phase progression or premature mitosis depending on the concentration of 7-hydroxystaurosporine and the kinetics of Cdc25C activation.
    Kohn EA, Ruth ND, Brown MK, Livingstone M, Eastman A.
    J Biol Chem; 2002 Jul 19; 277(29):26553-64. PubMed ID: 11953432
    [Abstract] [Full Text] [Related]

  • 11. Enhancement of camptothecin-induced cytotoxicity with UCN-01 in breast cancer cells: abrogation of S/G(2) arrest.
    Jones CB, Clements MK, Wasi S, Daoud SS.
    Cancer Chemother Pharmacol; 2000 Jul 19; 45(3):252-8. PubMed ID: 10663644
    [Abstract] [Full Text] [Related]

  • 12. UCN-01-mediated G1 arrest in normal but not tumor breast cells is pRb-dependent and p53-independent.
    Chen X, Lowe M, Keyomarsi K.
    Oncogene; 1999 Oct 07; 18(41):5691-702. PubMed ID: 10577141
    [Abstract] [Full Text] [Related]

  • 13. Abrogation of an S-phase checkpoint and potentiation of camptothecin cytotoxicity by 7-hydroxystaurosporine (UCN-01) in human cancer cell lines, possibly influenced by p53 function.
    Shao RG, Cao CX, Shimizu T, O'Connor PM, Kohn KW, Pommier Y.
    Cancer Res; 1997 Sep 15; 57(18):4029-35. PubMed ID: 9307289
    [Abstract] [Full Text] [Related]

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  • 15. Differential effects of UCN-01, staurosporine and CGP 41 251 on cell cycle progression and CDC2/cyclin B1 regulation in A431 cells synchronized at M phase by nocodazole.
    Akiyama T, Shimizu M, Okabe M, Tamaoki T, Akinaga S.
    Anticancer Drugs; 1999 Jan 15; 10(1):67-78. PubMed ID: 10194549
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  • 17. Distinct roles for p53 transactivation and repression in preventing UCN-01-mediated abrogation of DNA damage-induced arrest at S and G2 cell cycle checkpoints.
    Levesque AA, Kohn EA, Bresnick E, Eastman A.
    Oncogene; 2005 May 26; 24(23):3786-96. PubMed ID: 15782134
    [Abstract] [Full Text] [Related]

  • 18. RB status as a determinant of response to UCN-01 in non-small cell lung carcinoma.
    Mack PC, Gandara DR, Bowen C, Edelman MJ, Paglieroni T, Schnier JB, Gelmann EP, Gumerlock PH.
    Clin Cancer Res; 1999 Sep 26; 5(9):2596-604. PubMed ID: 10499638
    [Abstract] [Full Text] [Related]

  • 19. UCN-01 induces S and G2/M cell cycle arrest through the p53/p21(waf1) or CHK2/CDC25C pathways and can suppress invasion in human hepatoma cell lines.
    Wu G, Lin N, Xu L, Liu B, Feitelson MA.
    BMC Cancer; 2013 Mar 28; 13():167. PubMed ID: 23537372
    [Abstract] [Full Text] [Related]

  • 20. Abrogation of the radiation-induced G2 checkpoint by the staurosporine derivative UCN-01 is associated with radiosensitisation in a subset of colorectal tumour cell lines.
    Playle LC, Hicks DJ, Qualtrough D, Paraskeva C.
    Br J Cancer; 2002 Jul 29; 87(3):352-8. PubMed ID: 12177808
    [Abstract] [Full Text] [Related]

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