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Journal Abstract Search

332 related items for PubMed ID: 10571998

  • 1. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: the drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions.
    Hwang JT, Greenberg MM, Fuchs T, Gates KS.
    Biochemistry; 1999 Oct 26; 38(43):14248-55. PubMed ID: 10571998
    [Abstract] [Full Text] [Related]

  • 2. Direct evidence for bimodal DNA damage induced by tirapazamine.
    Daniels JS, Gates KS, Tronche C, Greenberg MM.
    Chem Res Toxicol; 1998 Nov 26; 11(11):1254-7. PubMed ID: 9815184
    [Abstract] [Full Text] [Related]

  • 3. Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: the role of redox equilibria.
    Anderson RF, Shinde SS, Hay MP, Denny WA.
    J Am Chem Soc; 2006 Jan 11; 128(1):245-9. PubMed ID: 16390153
    [Abstract] [Full Text] [Related]

  • 4. DNA strand damage product analysis provides evidence that the tumor cell-specific cytotoxin tirapazamine produces hydroxyl radical and acts as a surrogate for O(2).
    Chowdhury G, Junnotula V, Daniels JS, Greenberg MM, Gates KS.
    J Am Chem Soc; 2007 Oct 24; 129(42):12870-7. PubMed ID: 17900117
    [Abstract] [Full Text] [Related]

  • 5. Oxidation of 2-deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1,2,4-benzotriazine 1,4-dioxides.
    Shinde SS, Anderson RF, Hay MP, Gamage SA, Denny WA.
    J Am Chem Soc; 2004 Jun 30; 126(25):7865-74. PubMed ID: 15212534
    [Abstract] [Full Text] [Related]

  • 6. DNA damage induced via independent generation of the radical resulting from formal hydrogen atom abstraction from the C1'-position of a nucleotide.
    Tronche C, Goodman BK, Greenberg MM.
    Chem Biol; 1998 May 30; 5(5):263-71. PubMed ID: 9646942
    [Abstract] [Full Text] [Related]

  • 7. Metabolism of tirapazamine by multiple reductases in the nucleus.
    Delahoussaye YM, Evans JW, Brown JM.
    Biochem Pharmacol; 2001 Nov 01; 62(9):1201-9. PubMed ID: 11705453
    [Abstract] [Full Text] [Related]

  • 8. Chemical properties which control selectivity and efficacy of aromatic N-oxide bioreductive drugs.
    Wardman P, Priyadarsini KI, Dennis MF, Everett SA, Naylor MA, Patel KB, Stratford IJ, Stratford MR, Tracy M.
    Br J Cancer Suppl; 1996 Jul 01; 27():S70-4. PubMed ID: 8763850
    [Abstract] [Full Text] [Related]

  • 9. Enhanced conversion of DNA radical damage to double strand breaks by 1,2,4-benzotriazine 1,4-dioxides linked to a DNA binder compared to tirapazamine.
    Anderson RF, Harris TA, Hay MP, Denny WA.
    Chem Res Toxicol; 2003 Nov 01; 16(11):1477-83. PubMed ID: 14615975
    [Abstract] [Full Text] [Related]

  • 10. Dual action of tirapazamine in the induction of DNA strand breaks.
    Jones GD, Weinfeld M.
    Cancer Res; 1996 Apr 01; 56(7):1584-90. PubMed ID: 8603406
    [Abstract] [Full Text] [Related]

  • 11. Oxidative DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Kotandeniya D, Ganley B, Gates KS.
    Bioorg Med Chem Lett; 2002 Sep 02; 12(17):2325-9. PubMed ID: 12161126
    [Abstract] [Full Text] [Related]

  • 12. DNA damage induced via independent generation of the radical resulting from formal hydrogen atom abstraction from the C1'-position of a nucleotide.
    Tronche C, Goodman BK, Greenberg MM.
    Chem Biol; 1998 May 02; 5(5):263-71. PubMed ID: 9571217
    [Abstract] [Full Text] [Related]

  • 13. Toward hypoxia-selective DNA-alkylating agents built by grafting nitrogen mustards onto the bioreductively activated, hypoxia-selective DNA-oxidizing agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Johnson KM, Parsons ZD, Barnes CL, Gates KS.
    J Org Chem; 2014 Aug 15; 79(16):7520-31. PubMed ID: 25029663
    [Abstract] [Full Text] [Related]

  • 14. 3-amino-1,2,4-benzotriazine 4-oxide: characterization of a new metabolite arising from bioreductive processing of the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Fuchs T, Chowdhury G, Barnes CL, Gates KS.
    J Org Chem; 2001 Jan 12; 66(1):107-14. PubMed ID: 11429885
    [Abstract] [Full Text] [Related]

  • 15. DNA base damage by the antitumor agent 3-amino-1,2,4-benzotriazine 1,4-dioxide (tirapazamine).
    Birincioglu M, Jaruga P, Chowdhury G, Rodriguez H, Dizdaroglu M, Gates KS.
    J Am Chem Soc; 2003 Sep 24; 125(38):11607-15. PubMed ID: 13129365
    [Abstract] [Full Text] [Related]

  • 16. Isotopic labeling experiments that elucidate the mechanism of DNA strand cleavage by the hypoxia-selective antitumor agent 1,2,4-benzotriazine 1,4-di-N-oxide.
    Shen X, Rajapakse A, Gallazzi F, Junnotula V, Fuchs-Knotts T, Glaser R, Gates KS.
    Chem Res Toxicol; 2014 Jan 21; 27(1):111-8. PubMed ID: 24328261
    [Abstract] [Full Text] [Related]

  • 17. Initiation of DNA strand cleavage by 1,2,4-benzotriazine 1,4-dioxide antitumor agents: mechanistic insight from studies of 3-methyl-1,2,4-benzotriazine 1,4-dioxide.
    Junnotula V, Sarkar U, Sinha S, Gates KS.
    J Am Chem Soc; 2009 Jan 28; 131(3):1015-24. PubMed ID: 19117394
    [Abstract] [Full Text] [Related]

  • 18. Activation of 3-amino-1,2,4-benzotriazine 1,4-dioxide antitumor agents to oxidizing species following their one-electron reduction.
    Anderson RF, Shinde SS, Hay MP, Gamage SA, Denny WA.
    J Am Chem Soc; 2003 Jan 22; 125(3):748-56. PubMed ID: 12526674
    [Abstract] [Full Text] [Related]

  • 19. Direct and hydrogen peroxide-induced chromium(V) oxidation of deoxyribose in single-stranded and double-stranded calf thymus DNA.
    Sugden KD, Wetterhahn KE.
    Chem Res Toxicol; 1997 Dec 22; 10(12):1397-406. PubMed ID: 9437531
    [Abstract] [Full Text] [Related]

  • 20. Reactivity of 2'-deoxyuridin-1'-yl radical in various DNA structures.
    Hasiba W, Xu Y, Sugiyama H.
    Nucleic Acids Symp Ser (Oxf); 2005 Dec 22; (49):179-80. PubMed ID: 17150692
    [Abstract] [Full Text] [Related]

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