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104 related items for PubMed ID: 10574188

  • 1. Determination of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1- (4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, DY-9760e, in human plasma using solid-phase extraction and high-performance liquid chromatography with fluorescence detection.
    Tachibana S, Fukano A, Sudo K, Tanaka M.
    J Chromatogr B Biomed Sci Appl; 1999 Oct 29; 734(1):39-45. PubMed ID: 10574188
    [Abstract] [Full Text] [Related]

  • 2. 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, reduces brain edema through the inhibition of enhanced blood-brain barrier permeability after transient focal ischemia.
    Sato T, Morishima Y, Shirasaki Y.
    J Pharmacol Exp Ther; 2003 Mar 29; 304(3):1042-7. PubMed ID: 12604680
    [Abstract] [Full Text] [Related]

  • 3. In vitro metabolism of the calmodulin antagonist DY-9760e (3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate) by human liver microsomes: involvement of cytochromes p450 in atypical kinetics and potential drug interactions.
    Tachibana S, Fujimaki Y, Yokoyama H, Okazaki O, Sudo K.
    Drug Metab Dispos; 2005 Nov 29; 33(11):1628-36. PubMed ID: 16049129
    [Abstract] [Full Text] [Related]

  • 4. The neuroprotective effect of a novel calmodulin antagonist, 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate, in transient forebrain ischemia.
    Hashiguchi A, Kawano T, Yano S, Morioka M, Hamada J, Sato T, Shirasaki Y, Ushio Y, Fukunaga K.
    Neuroscience; 2003 Nov 29; 121(2):379-86. PubMed ID: 14521996
    [Abstract] [Full Text] [Related]

  • 5. The post-ischemic administration of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel calmodulin antagonist, prevents delayed neuronal death in gerbil hippocampus.
    Hashiguchi A, Yano S, Morioka M, Hamada J, Shirasaki Y, Kochi M, Fukunaga K.
    J Pharmacol Sci; 2004 Sep 29; 96(1):65-72. PubMed ID: 15359085
    [Abstract] [Full Text] [Related]

  • 6. Inhibition of neuronal nitric oxide synthase activity by 3-[2-[4-(3-chloro-2-methylphenyl)- 1-piperazinyl]ethyl]-5, 6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e), a novel neuroprotective agent, in vitro and in cultured neuroblastoma cells in situ.
    Fukunaga K, Ohmitsu M, Miyamoto E, Sato T, Sugimura M, Uchida T, Shirasaki Y.
    Biochem Pharmacol; 2000 Sep 01; 60(5):693-9. PubMed ID: 10927028
    [Abstract] [Full Text] [Related]

  • 7. Inhibition of dystrophin breakdown and endothelial nitric-oxide synthase uncoupling accounts for cytoprotection by 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) in left ventricular hypertrophied Mice.
    Han F, Lu YM, Hasegawa H, Kanai H, Hachimura E, Shirasaki Y, Fukunaga K.
    J Pharmacol Exp Ther; 2010 Feb 01; 332(2):421-8. PubMed ID: 19889795
    [Abstract] [Full Text] [Related]

  • 8. Cytoprotective effect of 3-[2-[4-(3-chloro-2-methylphenyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydrochloride 3.5 hydrate (DY-9760e) against ischemia/reperfusion-induced injury in rat heart involves inhibition of fodrin breakdown and protein tyrosine nitration.
    Hashimoto M, Takada Y, Takeuchi Y, Kasahara J, Hisa H, Shirasaki Y, Fukunaga K.
    J Pharmacol Sci; 2005 Jun 01; 98(2):142-50. PubMed ID: 15937403
    [Abstract] [Full Text] [Related]

  • 9. Pharmacokinetics and disposition of DY-9760e, a novel calmodulin antagonist, in rats and monkeys.
    Tachibana S, Fujimaki Y, Tachibana M, Tanaka M, Kurata T, Okazaki O, Sudo K.
    Arzneimittelforschung; 2005 Jun 01; 55(3):135-44. PubMed ID: 15819385
    [Abstract] [Full Text] [Related]

  • 10. DY-9760e, a novel calmodulin antagonist with cytoprotective action.
    Sugimura M, Sato T, Nakayama W, Morishima Y, Fukunaga K, Omitsu M, Miyamoto E, Shirasaki Y.
    Eur J Pharmacol; 1997 Oct 01; 336(1):99-106. PubMed ID: 9384259
    [Abstract] [Full Text] [Related]

  • 11. Post-ischemic administration of DY-9760e, a novel calmodulin antagonist, reduced infarct volume in the permanent focal ischemia model of spontaneously hypertensive rat.
    Takagi K, Sato T, Shirasaki Y, Narita K, Tamura A, Sano K.
    Neurol Res; 2001 Sep 01; 23(6):662-8. PubMed ID: 11547940
    [Abstract] [Full Text] [Related]

  • 12. DY-9760e, a novel calmodulin antagonist, reduces infarction after permanent focal cerebral ischemia in rats.
    Sato T, Takamori H, Shirasaki Y.
    Pharmacology; 2004 May 01; 71(1):38-45. PubMed ID: 15051921
    [Abstract] [Full Text] [Related]

  • 13. DY-9760e, a calmodulin antagonist, reduces brain damage after permanent focal cerebral ischemia in cats.
    Sugimura M, Takamori H, Fukushi H, Kitano Y, Kanazawa Y, Shirasaki Y.
    Biol Pharm Bull; 2005 Apr 01; 28(4):629-33. PubMed ID: 15802800
    [Abstract] [Full Text] [Related]

  • 14. 3-[2-[4-(3-Chloro-2-methylphenylmethyl)-1-piperazinyl]ethyl]-5,6-dimethoxy-1-(4-imidazolylmethyl)-1H-indazole dihydro-chloride 3.5 hydrate (DY-9760e) is neuroprotective in rat microsphere embolism: role of the cross-talk between calpain and caspase-3 through calpastatin.
    Han F, Shirasaki Y, Fukunaga K.
    J Pharmacol Exp Ther; 2006 May 01; 317(2):529-36. PubMed ID: 16467455
    [Abstract] [Full Text] [Related]

  • 15. DY-9760e, a novel calmodulin inhibitor, exhibits cardioprotective effects in the ischemic heart.
    Fukunaga K, Han F, Shioda N, Moriguchi S, Kasahara J, Shirasaki Y.
    Cardiovasc Drug Rev; 2006 May 01; 24(2):88-100. PubMed ID: 16961723
    [Abstract] [Full Text] [Related]

  • 16. DY-9760e, a novel calmodulin antagonist, reduces brain damage induced by transient focal cerebral ischemia.
    Sato T, Morishima Y, Sugimura M, Uchida T, Shirasaki Y.
    Eur J Pharmacol; 1999 Apr 09; 370(2):117-23. PubMed ID: 10323259
    [Abstract] [Full Text] [Related]

  • 17. Protective effect of DY-9760e, a calmodulin antagonist, against neuronal cell death.
    Takano H, Sugimura M, Kanazawa Y, Uchida T, Morishima Y, Shirasaki Y.
    Biol Pharm Bull; 2004 Nov 09; 27(11):1788-91. PubMed ID: 15516724
    [Abstract] [Full Text] [Related]

  • 18. Inhibitory effect of sulfobutyl ether beta-cyclodextrin on DY-9760e-induced cellular damage: In vitro and in vivo studies.
    Nagase Y, Arima H, Wada K, Sugawara T, Satoh H, Hirayama F, Uekama K.
    J Pharm Sci; 2003 Dec 09; 92(12):2466-74. PubMed ID: 14603492
    [Abstract] [Full Text] [Related]

  • 19. Protective effect of sulfobutyl ether beta-cyclodextrin on DY-9760e-induced hemolysis in vitro.
    Nagase Y, Hirata M, Arima H, Tajiri S, Nishimoto Y, Hirayama F, Irie T, Uekama K.
    J Pharm Sci; 2002 Nov 09; 91(11):2382-9. PubMed ID: 12379923
    [Abstract] [Full Text] [Related]

  • 20. Microsphere embolism-induced endothelial nitric oxide synthase expression mediates disruption of the blood-brain barrier in rat brain.
    Han F, Shirasaki Y, Fukunaga K.
    J Neurochem; 2006 Oct 09; 99(1):97-106. PubMed ID: 16987238
    [Abstract] [Full Text] [Related]

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