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122 related items for PubMed ID: 10586054

  • 1. Commitment to the CD4 lineage mediated by extracellular signal-related kinase mitogen-activated protein kinase and lck signaling.
    Sharp LL, Hedrick SM.
    J Immunol; 1999 Dec 15; 163(12):6598-605. PubMed ID: 10586054
    [Abstract] [Full Text] [Related]

  • 2. CD5 costimulation up-regulates the signaling to extracellular signal-regulated kinase activation in CD4+CD8+ thymocytes and supports their differentiation to the CD4 lineage.
    Zhou XY, Yashiro-Ohtani Y, Toyo-Oka K, Park CS, Tai XG, Hamaoka T, Fujiwara H.
    J Immunol; 2000 Feb 01; 164(3):1260-8. PubMed ID: 10640739
    [Abstract] [Full Text] [Related]

  • 3. MEK activity regulates negative selection of immature CD4+CD8+ thymocytes.
    Bommhardt U, Scheuring Y, Bickel C, Zamoyska R, Hünig T.
    J Immunol; 2000 Mar 01; 164(5):2326-37. PubMed ID: 10679067
    [Abstract] [Full Text] [Related]

  • 4. Activated p56lck directs maturation of both CD4 and CD8 single-positive thymocytes.
    Sohn SJ, Forbush KA, Pan XC, Perlmutter RM.
    J Immunol; 2001 Feb 15; 166(4):2209-17. PubMed ID: 11160274
    [Abstract] [Full Text] [Related]

  • 5. Regulation of T cell receptor expression in immature CD4+CD8+ thymocytes by p56lck tyrosine kinase: basis for differential signaling by CD4 and CD8 in immature thymocytes expressing both coreceptor molecules.
    Wiest DL, Yuan L, Jefferson J, Benveniste P, Tsokos M, Klausner RD, Glimcher LH, Samelson LE, Singer A.
    J Exp Med; 1993 Nov 01; 178(5):1701-12. PubMed ID: 8228817
    [Abstract] [Full Text] [Related]

  • 6. Activation of the extracellular signal-related kinase/mitogen-activated protein kinase pathway discriminates CD4 versus CD8 lineage commitment in the thymus.
    Bommhardt U, Basson MA, Krummrei U, Zamoyska R.
    J Immunol; 1999 Jul 15; 163(2):715-22. PubMed ID: 10395662
    [Abstract] [Full Text] [Related]

  • 7. Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model.
    Erman B, Alag AS, Dahle O, van Laethem F, Sarafova SD, Guinter TI, Sharrow SO, Grinberg A, Love PE, Singer A.
    J Immunol; 2006 Nov 15; 177(10):6613-25. PubMed ID: 17082573
    [Abstract] [Full Text] [Related]

  • 8. Lck activity controls CD4/CD8 T cell lineage commitment.
    Hernández-Hoyos G, Sohn SJ, Rothenberg EV, Alberola-Ila J.
    Immunity; 2000 Mar 15; 12(3):313-22. PubMed ID: 10755618
    [Abstract] [Full Text] [Related]

  • 9. Replacement of pre-T cell receptor signaling functions by the CD4 coreceptor.
    Norment AM, Forbush KA, Nguyen N, Malissen M, Perlmutter RM.
    J Exp Med; 1997 Jan 06; 185(1):121-30. PubMed ID: 8996248
    [Abstract] [Full Text] [Related]

  • 10. Enhanced T cell maturation and altered lineage commitment in T cell receptor/CD4-transgenic mice.
    Lieberman SA, Spain LM, Wang L, Berg LJ.
    Cell Immunol; 1995 Apr 15; 162(1):56-67. PubMed ID: 7704911
    [Abstract] [Full Text] [Related]

  • 11. A model for antigen-specific T-cell anergy: displacement of CD4-p56(lck) signalosome from the lipid rafts by a soluble, dimeric peptide-MHC class II chimera.
    Thomas S, Kumar R, Preda-Pais A, Casares S, Brumeanu TD.
    J Immunol; 2003 Jun 15; 170(12):5981-92. PubMed ID: 12794125
    [Abstract] [Full Text] [Related]

  • 12. The absence of Itk inhibits positive selection without changing lineage commitment.
    Lucas JA, Atherly LO, Berg LJ.
    J Immunol; 2002 Jun 15; 168(12):6142-51. PubMed ID: 12055226
    [Abstract] [Full Text] [Related]

  • 13. p56lck signals for regulating thymocyte development can be distinguished by their dependency on Rho function.
    Henning SW, Cantrell DA.
    J Exp Med; 1998 Sep 07; 188(5):931-9. PubMed ID: 9730894
    [Abstract] [Full Text] [Related]

  • 14. Development of the CD4 and CD8 lineage of T cells: instruction versus selection.
    Borgulya P, Kishi H, Müller U, Kirberg J, von Boehmer H.
    EMBO J; 1991 Apr 07; 10(4):913-8. PubMed ID: 1901264
    [Abstract] [Full Text] [Related]

  • 15. Role of TCR-induced extracellular signal-regulated kinase activation in the regulation of early IL-4 expression in naive CD4+ T cells.
    Jorritsma PJ, Brogdon JL, Bottomly K.
    J Immunol; 2003 Mar 01; 170(5):2427-34. PubMed ID: 12594266
    [Abstract] [Full Text] [Related]

  • 16. Two receptors, two kinases, and T cell lineage determination.
    Alarcón B, van Santen HM.
    Sci Signal; 2010 Mar 23; 3(114):pe11. PubMed ID: 20332426
    [Abstract] [Full Text] [Related]

  • 17. The cytoplasmic domain of CD4 promotes the development of CD4 lineage T cells.
    Itano A, Salmon P, Kioussis D, Tolaini M, Corbella P, Robey E.
    J Exp Med; 1996 Mar 01; 183(3):731-41. PubMed ID: 8642277
    [Abstract] [Full Text] [Related]

  • 18. [Coreceptor function of CD4 in response to MHC class I molecule].
    Zvezdova ES, Grinenko TS, Pobezinskaia EL, Pobezinskiĭ LA, Kazanskiĭ DB.
    Mol Biol (Mosk); 2008 Mar 01; 42(4):662-72. PubMed ID: 18856067
    [Abstract] [Full Text] [Related]

  • 19. Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes.
    Nakayama T, Wiest DL, Abraham KM, Munitz TI, Perlmutter RM, Singer A.
    Proc Natl Acad Sci U S A; 1993 Nov 15; 90(22):10534-8. PubMed ID: 7902564
    [Abstract] [Full Text] [Related]

  • 20. Molecular analysis of the interaction of p56lck with the CD4 and CD8 antigens.
    Rudd CE, Barber EK, Burgess KE, Hahn JY, Odysseos AD, Sy MS, Schlossman SF.
    Adv Exp Med Biol; 1991 Nov 15; 292():85-96. PubMed ID: 1835265
    [Abstract] [Full Text] [Related]

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